A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target
The identification of new drug targets is highly challenging, particularly for diseases of the brain. This study describes a general computational gene regulatory framework called CRAFT for drug target discovery, and the authors use CRAFT to identify the microglial membrane receptor Csf1R as a poten...
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Nature Portfolio
2018
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oai:doaj.org-article:c0cffc3635504945bbe2f39f8175da2f2021-12-02T17:31:16ZA systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target10.1038/s41467-018-06008-42041-1723https://doaj.org/article/c0cffc3635504945bbe2f39f8175da2f2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06008-4https://doaj.org/toc/2041-1723The identification of new drug targets is highly challenging, particularly for diseases of the brain. This study describes a general computational gene regulatory framework called CRAFT for drug target discovery, and the authors use CRAFT to identify the microglial membrane receptor Csf1R as a potential therapeutic target for epilepsy.Prashant K. SrivastavaJonathan van EyllPatrice GodardManuela MazzuferiAndree Delahaye-DuriezJuliette Van SteenwinckelPierre GressensBenedicte DanisCatherine VandenplasPatrik FoerchKarine LeclercqGeorges Mairet-CoelloAlvaro CardenasFrederic VanclefLiisi LaanisteIsabelle NiespodzianyJames KeaneyJulien GasserGaelle GilletKirill ShkuraSeon-Ah ChongJacques BehmoarasIrena KadiuEnrico PetrettoRafal M. KaminskiMichael R. JohnsonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
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Science Q Prashant K. Srivastava Jonathan van Eyll Patrice Godard Manuela Mazzuferi Andree Delahaye-Duriez Juliette Van Steenwinckel Pierre Gressens Benedicte Danis Catherine Vandenplas Patrik Foerch Karine Leclercq Georges Mairet-Coello Alvaro Cardenas Frederic Vanclef Liisi Laaniste Isabelle Niespodziany James Keaney Julien Gasser Gaelle Gillet Kirill Shkura Seon-Ah Chong Jacques Behmoaras Irena Kadiu Enrico Petretto Rafal M. Kaminski Michael R. Johnson A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target |
| description |
The identification of new drug targets is highly challenging, particularly for diseases of the brain. This study describes a general computational gene regulatory framework called CRAFT for drug target discovery, and the authors use CRAFT to identify the microglial membrane receptor Csf1R as a potential therapeutic target for epilepsy. |
| format |
article |
| author |
Prashant K. Srivastava Jonathan van Eyll Patrice Godard Manuela Mazzuferi Andree Delahaye-Duriez Juliette Van Steenwinckel Pierre Gressens Benedicte Danis Catherine Vandenplas Patrik Foerch Karine Leclercq Georges Mairet-Coello Alvaro Cardenas Frederic Vanclef Liisi Laaniste Isabelle Niespodziany James Keaney Julien Gasser Gaelle Gillet Kirill Shkura Seon-Ah Chong Jacques Behmoaras Irena Kadiu Enrico Petretto Rafal M. Kaminski Michael R. Johnson |
| author_facet |
Prashant K. Srivastava Jonathan van Eyll Patrice Godard Manuela Mazzuferi Andree Delahaye-Duriez Juliette Van Steenwinckel Pierre Gressens Benedicte Danis Catherine Vandenplas Patrik Foerch Karine Leclercq Georges Mairet-Coello Alvaro Cardenas Frederic Vanclef Liisi Laaniste Isabelle Niespodziany James Keaney Julien Gasser Gaelle Gillet Kirill Shkura Seon-Ah Chong Jacques Behmoaras Irena Kadiu Enrico Petretto Rafal M. Kaminski Michael R. Johnson |
| author_sort |
Prashant K. Srivastava |
| title |
A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target |
| title_short |
A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target |
| title_full |
A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target |
| title_fullStr |
A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target |
| title_full_unstemmed |
A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target |
| title_sort |
systems-level framework for drug discovery identifies csf1r as an anti-epileptic drug target |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/c0cffc3635504945bbe2f39f8175da2f |
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