The synthesis of biomimetic copper nanoparticles and its application in CT imaging
In this study, a simple and feasible method was proposed to prepare copper(Cu) nanoparticles (Cu@CEW) using egg albumin (CEW) as stabilizer and biological template, and it made a preliminary exploration on the application of computed tomography (CT). Under mild experimental conditions, the average p...
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| Main Authors: | , , |
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| Format: | article |
| Language: | EN ZH |
| Published: |
Academic Journals Center of Shanghai Normal University
2021
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| Subjects: | |
| Online Access: | https://doaj.org/article/c0d23e77034a4511bfe4dcb7c18f428c |
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| Summary: | In this study, a simple and feasible method was proposed to prepare copper(Cu) nanoparticles (Cu@CEW) using egg albumin (CEW) as stabilizer and biological template, and it made a preliminary exploration on the application of computed tomography (CT). Under mild experimental conditions, the average particle size of uniformly dispersed Cu@CEW synthesized by one-pot method is 4.62 nm. The stability test show that the prepared Cu@CEW have better dispersion and stability in multi-solution system, and there are no aggregation and sedimentation after 7 d of storage. At the same time, the biotoxicity test show that Cu@CEW have excellent biocompatibility, and under the experimental condition that human lung cancer cells A549 are co-incubated with 30 μg·mL<sup>-1</sup> Cu@CEW for 48 h, A549 cells maintain a high survival rate. Compared with the clinical contrast agent iohexol, Cu@CEW have obvious CT-enhanced imaging effect. This provides a new idea for the synthesis and application of metallic copper nanomaterials. |
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