The synthesis of biomimetic copper nanoparticles and its application in CT imaging

In this study, a simple and feasible method was proposed to prepare copper(Cu) nanoparticles (Cu@CEW) using egg albumin (CEW) as stabilizer and biological template, and it made a preliminary exploration on the application of computed tomography (CT). Under mild experimental conditions, the average p...

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Autores principales:	ZHANG Xin, CHU Zhongyun, JIA Nengqin
Formato:	article
Lenguaje:	EN ZH
Publicado:	Academic Journals Center of Shanghai Normal University 2021
Materias:	copper (cu) nanoparticles biological template computed tomography (ct) imaging Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/c0d23e77034a4511bfe4dcb7c18f428c
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spelling	oai:doaj.org-article:c0d23e77034a4511bfe4dcb7c18f428c2021-11-12T03:34:00ZThe synthesis of biomimetic copper nanoparticles and its application in CT imaging1000-513710.3969/J.ISSN.1000-5137.2021.05.005https://doaj.org/article/c0d23e77034a4511bfe4dcb7c18f428c2021-10-01T00:00:00Zhttp://qktg.shnu.edu.cn/zrb/shsfqkszrb/ch/reader/view_abstract.aspx?file_no=20210505https://doaj.org/toc/1000-5137In this study, a simple and feasible method was proposed to prepare copper(Cu) nanoparticles (Cu@CEW) using egg albumin (CEW) as stabilizer and biological template, and it made a preliminary exploration on the application of computed tomography (CT). Under mild experimental conditions, the average particle size of uniformly dispersed Cu@CEW synthesized by one-pot method is 4.62 nm. The stability test show that the prepared Cu@CEW have better dispersion and stability in multi-solution system, and there are no aggregation and sedimentation after 7 d of storage. At the same time, the biotoxicity test show that Cu@CEW have excellent biocompatibility, and under the experimental condition that human lung cancer cells A549 are co-incubated with 30 μg·mL<sup>-1</sup> Cu@CEW for 48 h, A549 cells maintain a high survival rate. Compared with the clinical contrast agent iohexol, Cu@CEW have obvious CT-enhanced imaging effect. This provides a new idea for the synthesis and application of metallic copper nanomaterials.ZHANG XinCHU ZhongyunJIA NengqinAcademic Journals Center of Shanghai Normal Universityarticlecopper (cu) nanoparticlesbiological templatecomputed tomography (ct) imagingScience (General)Q1-390ENZHJournal of Shanghai Normal University (Natural Sciences), Vol 50, Iss 5, Pp 553-558 (2021)
institution	DOAJ
collection	DOAJ
language	EN ZH
topic	copper (cu) nanoparticles biological template computed tomography (ct) imaging Science (General) Q1-390
spellingShingle	copper (cu) nanoparticles biological template computed tomography (ct) imaging Science (General) Q1-390 ZHANG Xin CHU Zhongyun JIA Nengqin The synthesis of biomimetic copper nanoparticles and its application in CT imaging
description	In this study, a simple and feasible method was proposed to prepare copper(Cu) nanoparticles (Cu@CEW) using egg albumin (CEW) as stabilizer and biological template, and it made a preliminary exploration on the application of computed tomography (CT). Under mild experimental conditions, the average particle size of uniformly dispersed Cu@CEW synthesized by one-pot method is 4.62 nm. The stability test show that the prepared Cu@CEW have better dispersion and stability in multi-solution system, and there are no aggregation and sedimentation after 7 d of storage. At the same time, the biotoxicity test show that Cu@CEW have excellent biocompatibility, and under the experimental condition that human lung cancer cells A549 are co-incubated with 30 μg·mL<sup>-1</sup> Cu@CEW for 48 h, A549 cells maintain a high survival rate. Compared with the clinical contrast agent iohexol, Cu@CEW have obvious CT-enhanced imaging effect. This provides a new idea for the synthesis and application of metallic copper nanomaterials.
format	article
author	ZHANG Xin CHU Zhongyun JIA Nengqin
author_facet	ZHANG Xin CHU Zhongyun JIA Nengqin
author_sort	ZHANG Xin
title	The synthesis of biomimetic copper nanoparticles and its application in CT imaging
title_short	The synthesis of biomimetic copper nanoparticles and its application in CT imaging
title_full	The synthesis of biomimetic copper nanoparticles and its application in CT imaging
title_fullStr	The synthesis of biomimetic copper nanoparticles and its application in CT imaging
title_full_unstemmed	The synthesis of biomimetic copper nanoparticles and its application in CT imaging
title_sort	synthesis of biomimetic copper nanoparticles and its application in ct imaging
publisher	Academic Journals Center of Shanghai Normal University
publishDate	2021
url	https://doaj.org/article/c0d23e77034a4511bfe4dcb7c18f428c
work_keys_str_mv	AT zhangxin thesynthesisofbiomimeticcoppernanoparticlesanditsapplicationinctimaging AT chuzhongyun thesynthesisofbiomimeticcoppernanoparticlesanditsapplicationinctimaging AT jianengqin thesynthesisofbiomimeticcoppernanoparticlesanditsapplicationinctimaging AT zhangxin synthesisofbiomimeticcoppernanoparticlesanditsapplicationinctimaging AT chuzhongyun synthesisofbiomimeticcoppernanoparticlesanditsapplicationinctimaging AT jianengqin synthesisofbiomimeticcoppernanoparticlesanditsapplicationinctimaging
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The synthesis of biomimetic copper nanoparticles and its application in CT imaging

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