The influence of the serotonergic system on the personality and quality of life of postmenopausal women

Daria Schneider-Matyka,1 Anna Jurczak,1 Małgorzata Szkup,1 Agnieszka Samochowiec,2 Anna Grzywacz,3 Sylwia Wieder-Huszla,1 Elżbieta Grochans1 1Department of Nursing, Pomeranian Medical University in Szczecin, 2Department of Clinical Psychology, Institute of Psychology, University of Szczecin, 3Depar...

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Autores principales:	Schneider-Matyka D, Jurczak A, Szkup M, Samochowiec A, Grzywacz A, Wieder-Huszla S, Grochans E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	menopause quality of life personality 5-HTT MAO-A Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/c0d2f66ee2954bc9a2eeae5171887230
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spelling	oai:doaj.org-article:c0d2f66ee2954bc9a2eeae51718872302021-12-02T08:01:11ZThe influence of the serotonergic system on the personality and quality of life of postmenopausal women1178-1998https://doaj.org/article/c0d2f66ee2954bc9a2eeae51718872302017-06-01T00:00:00Zhttps://www.dovepress.com/the-influence-of-the-serotonergic-system-on-the-personality-and-qualit-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Daria Schneider-Matyka,1 Anna Jurczak,1 Małgorzata Szkup,1 Agnieszka Samochowiec,2 Anna Grzywacz,3 Sylwia Wieder-Huszla,1 Elżbieta Grochans1 1Department of Nursing, Pomeranian Medical University in Szczecin, 2Department of Clinical Psychology, Institute of Psychology, University of Szczecin, 3Department of Psychiatry, Pomeranian Medical University in Szczecin, Szczecin, Poland Abstract: The aim of this study was to establish the relationship between personality traits of postmenopausal women and the presence of the 44-bp VNTR polymorphism in the serotonin transporter (5-HTT) (SLC6A4) promoter region and the 30-bp VNTR polymorphism in the MAO-A promoter region. The study’s aim was also to determine the influence of personality traits on the quality of postmenopausal women’s lives. The study involved 214 postmenopausal women from northwest Poland, with an average age of 56.8±4.08 years. It was performed using the Temperament and Character Inventory-Revised and the Short Form Health Survey. DNA polymorphisms were identified by means of polymerase chain reaction. Analysis demonstrated that the s/s genotype was significantly more common than the l/l genotype in women with higher fear of uncertainty. In a group with higher enlightened second nature and empathy, the l/s genotype was considerably more common than the l/l genotype. There were statistically significant associations between selected aspects of quality of life and personality traits such as enlightened second nature, transpersonal identification, purposefulness, and self-transcendence. The s/s genotype of the 44-bp VNTR polymorphism in the 5-HTT (SLC6A4) promoter region may increase the tendency to avoid harm within the fear of uncertainty dimension. Carriers of this genotype may have predisposition to anxiety and depressive disorders. The l/s genotype of the 44-bp VNTR polymorphism in the 5-HTT (SLC6A4) promoter region contributes to increased expression of enlightened second nature and empathy. Some personality traits may influence the quality of women’s lives. Keywords: menopause, quality of life, personality, 5-HTT, MAO-ASchneider-Matyka DJurczak ASzkup MSamochowiec AGrzywacz AWieder-Huszla SGrochans EDove Medical Pressarticlemenopausequality of lifepersonality5-HTTMAO-AGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 963-970 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	menopause quality of life personality 5-HTT MAO-A Geriatrics RC952-954.6
spellingShingle	menopause quality of life personality 5-HTT MAO-A Geriatrics RC952-954.6 Schneider-Matyka D Jurczak A Szkup M Samochowiec A Grzywacz A Wieder-Huszla S Grochans E The influence of the serotonergic system on the personality and quality of life of postmenopausal women
description	Daria Schneider-Matyka,1 Anna Jurczak,1 Małgorzata Szkup,1 Agnieszka Samochowiec,2 Anna Grzywacz,3 Sylwia Wieder-Huszla,1 Elżbieta Grochans1 1Department of Nursing, Pomeranian Medical University in Szczecin, 2Department of Clinical Psychology, Institute of Psychology, University of Szczecin, 3Department of Psychiatry, Pomeranian Medical University in Szczecin, Szczecin, Poland Abstract: The aim of this study was to establish the relationship between personality traits of postmenopausal women and the presence of the 44-bp VNTR polymorphism in the serotonin transporter (5-HTT) (SLC6A4) promoter region and the 30-bp VNTR polymorphism in the MAO-A promoter region. The study’s aim was also to determine the influence of personality traits on the quality of postmenopausal women’s lives. The study involved 214 postmenopausal women from northwest Poland, with an average age of 56.8±4.08 years. It was performed using the Temperament and Character Inventory-Revised and the Short Form Health Survey. DNA polymorphisms were identified by means of polymerase chain reaction. Analysis demonstrated that the s/s genotype was significantly more common than the l/l genotype in women with higher fear of uncertainty. In a group with higher enlightened second nature and empathy, the l/s genotype was considerably more common than the l/l genotype. There were statistically significant associations between selected aspects of quality of life and personality traits such as enlightened second nature, transpersonal identification, purposefulness, and self-transcendence. The s/s genotype of the 44-bp VNTR polymorphism in the 5-HTT (SLC6A4) promoter region may increase the tendency to avoid harm within the fear of uncertainty dimension. Carriers of this genotype may have predisposition to anxiety and depressive disorders. The l/s genotype of the 44-bp VNTR polymorphism in the 5-HTT (SLC6A4) promoter region contributes to increased expression of enlightened second nature and empathy. Some personality traits may influence the quality of women’s lives. Keywords: menopause, quality of life, personality, 5-HTT, MAO-A
format	article
author	Schneider-Matyka D Jurczak A Szkup M Samochowiec A Grzywacz A Wieder-Huszla S Grochans E
author_facet	Schneider-Matyka D Jurczak A Szkup M Samochowiec A Grzywacz A Wieder-Huszla S Grochans E
author_sort	Schneider-Matyka D
title	The influence of the serotonergic system on the personality and quality of life of postmenopausal women
title_short	The influence of the serotonergic system on the personality and quality of life of postmenopausal women
title_full	The influence of the serotonergic system on the personality and quality of life of postmenopausal women
title_fullStr	The influence of the serotonergic system on the personality and quality of life of postmenopausal women
title_full_unstemmed	The influence of the serotonergic system on the personality and quality of life of postmenopausal women
title_sort	influence of the serotonergic system on the personality and quality of life of postmenopausal women
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/c0d2f66ee2954bc9a2eeae5171887230
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The influence of the serotonergic system on the personality and quality of life of postmenopausal women

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