The IL6-like Cytokine Family: Role and Biomarker Potential in Breast Cancer

IL6-like cytokines are a family of regulators with a complex, pleiotropic role in both the healthy organism, where they regulate immunity and homeostasis, and in different diseases, including cancer. Here we summarise how these cytokines exert their effect through the shared signal transducer IL6ST...

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Autores principales:	Carlos Martínez-Pérez, Charlene Kay, James Meehan, Mark Gray, J. Michael Dixon, Arran K. Turnbull
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	breast cancer cytokine signalling IL6ST gp130 biomarkers translational research Medicine R
Acceso en línea:	https://doaj.org/article/c0d4cd1441174b36aae0295e48fa734c
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spelling	oai:doaj.org-article:c0d4cd1441174b36aae0295e48fa734c2021-11-25T18:06:54ZThe IL6-like Cytokine Family: Role and Biomarker Potential in Breast Cancer10.3390/jpm111110732075-4426https://doaj.org/article/c0d4cd1441174b36aae0295e48fa734c2021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1073https://doaj.org/toc/2075-4426IL6-like cytokines are a family of regulators with a complex, pleiotropic role in both the healthy organism, where they regulate immunity and homeostasis, and in different diseases, including cancer. Here we summarise how these cytokines exert their effect through the shared signal transducer IL6ST (gp130) and we review the extensive evidence on the role that different members of this family play in breast cancer. Additionally, we discuss how the different cytokines, their related receptors and downstream effectors, as well as specific polymorphisms in these molecules, can serve as predictive or prognostic biomarkers with the potential for clinical application in breast cancer. Lastly, we also discuss how our increasing understanding of this complex signalling axis presents promising opportunities for the development or repurposing of therapeutic strategies against cancer and, specifically, breast neoplasms.Carlos Martínez-PérezCharlene KayJames MeehanMark GrayJ. Michael DixonArran K. TurnbullMDPI AGarticlebreast cancercytokine signallingIL6STgp130biomarkerstranslational researchMedicineRENJournal of Personalized Medicine, Vol 11, Iss 1073, p 1073 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer cytokine signalling IL6ST gp130 biomarkers translational research Medicine R
spellingShingle	breast cancer cytokine signalling IL6ST gp130 biomarkers translational research Medicine R Carlos Martínez-Pérez Charlene Kay James Meehan Mark Gray J. Michael Dixon Arran K. Turnbull The IL6-like Cytokine Family: Role and Biomarker Potential in Breast Cancer
description	IL6-like cytokines are a family of regulators with a complex, pleiotropic role in both the healthy organism, where they regulate immunity and homeostasis, and in different diseases, including cancer. Here we summarise how these cytokines exert their effect through the shared signal transducer IL6ST (gp130) and we review the extensive evidence on the role that different members of this family play in breast cancer. Additionally, we discuss how the different cytokines, their related receptors and downstream effectors, as well as specific polymorphisms in these molecules, can serve as predictive or prognostic biomarkers with the potential for clinical application in breast cancer. Lastly, we also discuss how our increasing understanding of this complex signalling axis presents promising opportunities for the development or repurposing of therapeutic strategies against cancer and, specifically, breast neoplasms.
format	article
author	Carlos Martínez-Pérez Charlene Kay James Meehan Mark Gray J. Michael Dixon Arran K. Turnbull
author_facet	Carlos Martínez-Pérez Charlene Kay James Meehan Mark Gray J. Michael Dixon Arran K. Turnbull
author_sort	Carlos Martínez-Pérez
title	The IL6-like Cytokine Family: Role and Biomarker Potential in Breast Cancer
title_short	The IL6-like Cytokine Family: Role and Biomarker Potential in Breast Cancer
title_full	The IL6-like Cytokine Family: Role and Biomarker Potential in Breast Cancer
title_fullStr	The IL6-like Cytokine Family: Role and Biomarker Potential in Breast Cancer
title_full_unstemmed	The IL6-like Cytokine Family: Role and Biomarker Potential in Breast Cancer
title_sort	il6-like cytokine family: role and biomarker potential in breast cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c0d4cd1441174b36aae0295e48fa734c
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The IL6-like Cytokine Family: Role and Biomarker Potential in Breast Cancer

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