Association of Diabetes Mellitus and Alcohol Abuse with Cancer: Molecular Mechanisms and Clinical Significance

Diabetes mellitus (DM), one of the metabolic diseases which is characterized by sustained hyperglycemia, is a life-threatening disease. The global prevalence of DM is on the rise, mainly in low- and middle-income countries. Diabetes is a major cause of blindness, heart attacks, kidney failure, strok...

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Autores principales:	Bao Q. Lam, Rashmi Srivastava, Jason Morvant, Sharmila Shankar, Rakesh K. Srivastava
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	diabetes mellitus alcoholism breast cancer pancreatic cancers gastric cancer colorectal cancer Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c0d58f770f4e40f3aed6e6866b098189
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spelling	oai:doaj.org-article:c0d58f770f4e40f3aed6e6866b0981892021-11-25T17:11:16ZAssociation of Diabetes Mellitus and Alcohol Abuse with Cancer: Molecular Mechanisms and Clinical Significance10.3390/cells101130772073-4409https://doaj.org/article/c0d58f770f4e40f3aed6e6866b0981892021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3077https://doaj.org/toc/2073-4409Diabetes mellitus (DM), one of the metabolic diseases which is characterized by sustained hyperglycemia, is a life-threatening disease. The global prevalence of DM is on the rise, mainly in low- and middle-income countries. Diabetes is a major cause of blindness, heart attacks, kidney failure, stroke, and lower limb amputation. Type 2 diabetes mellitus (T2DM) is a form of diabetes that is characterized by high blood sugar and insulin resistance. T2DM can be prevented or delayed by a healthy diet, regular physical activity, maintaining normal body weight, and avoiding alcohol and tobacco use. Ethanol and its metabolites can cause differentiation defects in stem cells and promote inflammatory injury and carcinogenesis in several tissues. Recent studies have suggested that diabetes can be treated, and its consequences can be avoided or delayed with proper management. DM has a greater risk for several cancers, such as breast, colorectal, endometrial, pancreatic, gallbladder, renal, and liver cancer. The incidence of cancer is significantly higher in patients with DM than in those without DM. In addition to DM, alcohol abuse is also a risk factor for many cancers. We present a review of the recent studies investigating the association of both DM and alcohol abuse with cancer incidence.Bao Q. LamRashmi SrivastavaJason MorvantSharmila ShankarRakesh K. SrivastavaMDPI AGarticlediabetes mellitusalcoholismbreast cancerpancreatic cancersgastric cancercolorectal cancerBiology (General)QH301-705.5ENCells, Vol 10, Iss 3077, p 3077 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus alcoholism breast cancer pancreatic cancers gastric cancer colorectal cancer Biology (General) QH301-705.5
spellingShingle	diabetes mellitus alcoholism breast cancer pancreatic cancers gastric cancer colorectal cancer Biology (General) QH301-705.5 Bao Q. Lam Rashmi Srivastava Jason Morvant Sharmila Shankar Rakesh K. Srivastava Association of Diabetes Mellitus and Alcohol Abuse with Cancer: Molecular Mechanisms and Clinical Significance
description	Diabetes mellitus (DM), one of the metabolic diseases which is characterized by sustained hyperglycemia, is a life-threatening disease. The global prevalence of DM is on the rise, mainly in low- and middle-income countries. Diabetes is a major cause of blindness, heart attacks, kidney failure, stroke, and lower limb amputation. Type 2 diabetes mellitus (T2DM) is a form of diabetes that is characterized by high blood sugar and insulin resistance. T2DM can be prevented or delayed by a healthy diet, regular physical activity, maintaining normal body weight, and avoiding alcohol and tobacco use. Ethanol and its metabolites can cause differentiation defects in stem cells and promote inflammatory injury and carcinogenesis in several tissues. Recent studies have suggested that diabetes can be treated, and its consequences can be avoided or delayed with proper management. DM has a greater risk for several cancers, such as breast, colorectal, endometrial, pancreatic, gallbladder, renal, and liver cancer. The incidence of cancer is significantly higher in patients with DM than in those without DM. In addition to DM, alcohol abuse is also a risk factor for many cancers. We present a review of the recent studies investigating the association of both DM and alcohol abuse with cancer incidence.
format	article
author	Bao Q. Lam Rashmi Srivastava Jason Morvant Sharmila Shankar Rakesh K. Srivastava
author_facet	Bao Q. Lam Rashmi Srivastava Jason Morvant Sharmila Shankar Rakesh K. Srivastava
author_sort	Bao Q. Lam
title	Association of Diabetes Mellitus and Alcohol Abuse with Cancer: Molecular Mechanisms and Clinical Significance
title_short	Association of Diabetes Mellitus and Alcohol Abuse with Cancer: Molecular Mechanisms and Clinical Significance
title_full	Association of Diabetes Mellitus and Alcohol Abuse with Cancer: Molecular Mechanisms and Clinical Significance
title_fullStr	Association of Diabetes Mellitus and Alcohol Abuse with Cancer: Molecular Mechanisms and Clinical Significance
title_full_unstemmed	Association of Diabetes Mellitus and Alcohol Abuse with Cancer: Molecular Mechanisms and Clinical Significance
title_sort	association of diabetes mellitus and alcohol abuse with cancer: molecular mechanisms and clinical significance
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c0d58f770f4e40f3aed6e6866b098189
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Association of Diabetes Mellitus and Alcohol Abuse with Cancer: Molecular Mechanisms and Clinical Significance

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