Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome

Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome

Natural killer (NK) cells are important innate immune cells with diverse functions. Here the authors use single-cell RNA-sequencing of purified human bone marrow and peripheral blood NK cells to define five populations of NK cells with distinct transcriptomic profile to further our understanding of...

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Auteurs principaux: Chao Yang, Jason R. Siebert, Robert Burns, Zachary J. Gerbec, Benedetta Bonacci, Amy Rymaszewski, Mary Rau, Matthew J. Riese, Sridhar Rao, Karen-Sue Carlson, John M. Routes, James W. Verbsky, Monica S. Thakar, Subramaniam Malarkannan
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Accès en ligne:https://doaj.org/article/c0d7b97edd22455d8504f80ccc09c6b8
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Résumé:Natural killer (NK) cells are important innate immune cells with diverse functions. Here the authors use single-cell RNA-sequencing of purified human bone marrow and peripheral blood NK cells to define five populations of NK cells with distinct transcriptomic profile to further our understanding of NK development and heterogeneity.

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