Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome

Natural killer (NK) cells are important innate immune cells with diverse functions. Here the authors use single-cell RNA-sequencing of purified human bone marrow and peripheral blood NK cells to define five populations of NK cells with distinct transcriptomic profile to further our understanding of...

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Autores principales:	Chao Yang, Jason R. Siebert, Robert Burns, Zachary J. Gerbec, Benedetta Bonacci, Amy Rymaszewski, Mary Rau, Matthew J. Riese, Sridhar Rao, Karen-Sue Carlson, John M. Routes, James W. Verbsky, Monica S. Thakar, Subramaniam Malarkannan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c0d7b97edd22455d8504f80ccc09c6b8
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spelling	oai:doaj.org-article:c0d7b97edd22455d8504f80ccc09c6b82021-12-02T16:58:16ZHeterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome10.1038/s41467-019-11947-72041-1723https://doaj.org/article/c0d7b97edd22455d8504f80ccc09c6b82019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11947-7https://doaj.org/toc/2041-1723Natural killer (NK) cells are important innate immune cells with diverse functions. Here the authors use single-cell RNA-sequencing of purified human bone marrow and peripheral blood NK cells to define five populations of NK cells with distinct transcriptomic profile to further our understanding of NK development and heterogeneity.Chao YangJason R. SiebertRobert BurnsZachary J. GerbecBenedetta BonacciAmy RymaszewskiMary RauMatthew J. RieseSridhar RaoKaren-Sue CarlsonJohn M. RoutesJames W. VerbskyMonica S. ThakarSubramaniam MalarkannanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chao Yang Jason R. Siebert Robert Burns Zachary J. Gerbec Benedetta Bonacci Amy Rymaszewski Mary Rau Matthew J. Riese Sridhar Rao Karen-Sue Carlson John M. Routes James W. Verbsky Monica S. Thakar Subramaniam Malarkannan Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome
description	Natural killer (NK) cells are important innate immune cells with diverse functions. Here the authors use single-cell RNA-sequencing of purified human bone marrow and peripheral blood NK cells to define five populations of NK cells with distinct transcriptomic profile to further our understanding of NK development and heterogeneity.
format	article
author	Chao Yang Jason R. Siebert Robert Burns Zachary J. Gerbec Benedetta Bonacci Amy Rymaszewski Mary Rau Matthew J. Riese Sridhar Rao Karen-Sue Carlson John M. Routes James W. Verbsky Monica S. Thakar Subramaniam Malarkannan
author_facet	Chao Yang Jason R. Siebert Robert Burns Zachary J. Gerbec Benedetta Bonacci Amy Rymaszewski Mary Rau Matthew J. Riese Sridhar Rao Karen-Sue Carlson John M. Routes James W. Verbsky Monica S. Thakar Subramaniam Malarkannan
author_sort	Chao Yang
title	Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome
title_short	Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome
title_full	Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome
title_fullStr	Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome
title_full_unstemmed	Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome
title_sort	heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c0d7b97edd22455d8504f80ccc09c6b8
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Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome

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