Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents

Current cysteine bioconjugation strategies for protein-drug conjugates synthesis often yield heterogeneous and poorly stable products. Here, the authors use carbonylacrylic derivatives to selectively modify cysteine residues and synthesize biologically functional antibody conjugates highly stable in...

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Autores principales:	Barbara Bernardim, Pedro M.S.D. Cal, Maria J. Matos, Bruno L. Oliveira, Nuria Martínez-Sáez, Inês S. Albuquerque, Elizabeth Perkins, Francisco Corzana, Antonio C.B. Burtoloso, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c0d7ebdccc9c4ce596735356cd570e4c
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spelling	oai:doaj.org-article:c0d7ebdccc9c4ce596735356cd570e4c2021-12-02T15:35:19ZStoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents10.1038/ncomms131282041-1723https://doaj.org/article/c0d7ebdccc9c4ce596735356cd570e4c2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13128https://doaj.org/toc/2041-1723Current cysteine bioconjugation strategies for protein-drug conjugates synthesis often yield heterogeneous and poorly stable products. Here, the authors use carbonylacrylic derivatives to selectively modify cysteine residues and synthesize biologically functional antibody conjugates highly stable in plasma.Barbara BernardimPedro M.S.D. CalMaria J. MatosBruno L. OliveiraNuria Martínez-SáezInês S. AlbuquerqueElizabeth PerkinsFrancisco CorzanaAntonio C.B. BurtolosoGonzalo Jiménez-OsésGonçalo J. L. BernardesNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Barbara Bernardim Pedro M.S.D. Cal Maria J. Matos Bruno L. Oliveira Nuria Martínez-Sáez Inês S. Albuquerque Elizabeth Perkins Francisco Corzana Antonio C.B. Burtoloso Gonzalo Jiménez-Osés Gonçalo J. L. Bernardes Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents
description	Current cysteine bioconjugation strategies for protein-drug conjugates synthesis often yield heterogeneous and poorly stable products. Here, the authors use carbonylacrylic derivatives to selectively modify cysteine residues and synthesize biologically functional antibody conjugates highly stable in plasma.
format	article
author	Barbara Bernardim Pedro M.S.D. Cal Maria J. Matos Bruno L. Oliveira Nuria Martínez-Sáez Inês S. Albuquerque Elizabeth Perkins Francisco Corzana Antonio C.B. Burtoloso Gonzalo Jiménez-Osés Gonçalo J. L. Bernardes
author_facet	Barbara Bernardim Pedro M.S.D. Cal Maria J. Matos Bruno L. Oliveira Nuria Martínez-Sáez Inês S. Albuquerque Elizabeth Perkins Francisco Corzana Antonio C.B. Burtoloso Gonzalo Jiménez-Osés Gonçalo J. L. Bernardes
author_sort	Barbara Bernardim
title	Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents
title_short	Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents
title_full	Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents
title_fullStr	Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents
title_full_unstemmed	Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents
title_sort	stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c0d7ebdccc9c4ce596735356cd570e4c
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Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents

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