ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice

ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice

Here, the authors show that Zika virus (ZIKV) infection induces Th1-like Tfh cells that depend on T-bet for their development and are essential for class switching of ZIKV-specific IgG2c antibodies and maintenance of long-term neutralizing antibody responses.

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Autores principales: Huabin Liang, Jinyi Tang, Zhihua Liu, Yuanhua Liu, Yuanyuan Huang, Yongfen Xu, Pei Hao, Zhinan Yin, Jin Zhong, Lilin Ye, Xia Jin, Haikun Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
Q
Acceso en línea:https://doaj.org/article/c0deb62fa29f4a80a6829bd8e33f76cf
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spelling oai:doaj.org-article:c0deb62fa29f4a80a6829bd8e33f76cf2021-12-02T15:35:10ZZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice10.1038/s41467-019-11754-02041-1723https://doaj.org/article/c0deb62fa29f4a80a6829bd8e33f76cf2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11754-0https://doaj.org/toc/2041-1723Here, the authors show that Zika virus (ZIKV) infection induces Th1-like Tfh cells that depend on T-bet for their development and are essential for class switching of ZIKV-specific IgG2c antibodies and maintenance of long-term neutralizing antibody responses.Huabin LiangJinyi TangZhihua LiuYuanhua LiuYuanyuan HuangYongfen XuPei HaoZhinan YinJin ZhongLilin YeXia JinHaikun WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Huabin Liang
Jinyi Tang
Zhihua Liu
Yuanhua Liu
Yuanyuan Huang
Yongfen Xu
Pei Hao
Zhinan Yin
Jin Zhong
Lilin Ye
Xia Jin
Haikun Wang
ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice
description Here, the authors show that Zika virus (ZIKV) infection induces Th1-like Tfh cells that depend on T-bet for their development and are essential for class switching of ZIKV-specific IgG2c antibodies and maintenance of long-term neutralizing antibody responses.
format article
author Huabin Liang
Jinyi Tang
Zhihua Liu
Yuanhua Liu
Yuanyuan Huang
Yongfen Xu
Pei Hao
Zhinan Yin
Jin Zhong
Lilin Ye
Xia Jin
Haikun Wang
author_facet Huabin Liang
Jinyi Tang
Zhihua Liu
Yuanhua Liu
Yuanyuan Huang
Yongfen Xu
Pei Hao
Zhinan Yin
Jin Zhong
Lilin Ye
Xia Jin
Haikun Wang
author_sort Huabin Liang
title ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice
title_short ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice
title_full ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice
title_fullStr ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice
title_full_unstemmed ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice
title_sort zikv infection induces robust th1-like tfh cell and long-term protective antibody responses in immunocompetent mice
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/c0deb62fa29f4a80a6829bd8e33f76cf
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