Increased Incidence of Pediatric Diabetic Ketoacidosis After COVID-19: A Two-Center Retrospective Study in Korea

Min Jeong Han,1 Jun Ho Heo2 1Department of Pediatrics, Chonbuk National University Hospital, Jeonju, 54907, Korea; 2Department of Emergency Medicine, Wonkwang National University Hospital, Iksan, 54887, KoreaCorrespondence: Jun Ho HeoDepartment of Emergency Medicine, Wonkwang National University Hos...

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Autores principales:	Han MJ, Heo JH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	coronavirus disease 2019 diabetes diabetic ketoacidosis pediatric diabetes Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/c0e06912518742529c4502cf802639e7
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spelling	oai:doaj.org-article:c0e06912518742529c4502cf802639e72021-12-02T16:23:32ZIncreased Incidence of Pediatric Diabetic Ketoacidosis After COVID-19: A Two-Center Retrospective Study in Korea1178-7007https://doaj.org/article/c0e06912518742529c4502cf802639e72021-02-01T00:00:00Zhttps://www.dovepress.com/increased-incidence-of-pediatric-diabetic-ketoacidosis-after-covid-19--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Min Jeong Han,1 Jun Ho Heo2 1Department of Pediatrics, Chonbuk National University Hospital, Jeonju, 54907, Korea; 2Department of Emergency Medicine, Wonkwang National University Hospital, Iksan, 54887, KoreaCorrespondence: Jun Ho HeoDepartment of Emergency Medicine, Wonkwang National University Hospital, 895, Muwang-Ro, Iksan, 54887, KoreaTel +82-63-8591150Fax +82-63-8592129Email tesaza22@hanmail.netPurpose: We evaluated the clinical characteristics and severity of diabetic ketoacidosis (DKA) in children before and after the coronavirus disease 2019 (COVID-19) outbreak to identify its indirect effects on DKA incidence.Patients and Methods: This retrospective study included 19 children with DKA admitted to the emergency room (ER) in two centers in Jeonbuk province, Korea during the first 6 months of the year from 2017 to 2020. Data were collected on age, height, body weight, clinical symptoms, diabetic mellitus (DM) type, and laboratory findings. DKA severity was based on the presence of acute kidney injury, cerebrovascular accident, and altered mental status. The ratio of patients with DKA in all pediatric patients who visited the study ERs and in the Jeonbuk population was also determined.Results: There were no differences in anthropometric characteristics and complication rates between the pre-COVID-19 and COVID-19 periods; however, the rate of polydipsia was significantly higher in the COVID-19 period. All seven patients admitted during the COVID-19 pandemic (100%) had polydipsia and polyuria and were newly diagnosed with DM. The rate of pediatric patients with DKA admitted to the ER in 2020 (0.459%) was more than twice the mean rate of 0.206% for the four-year period. The incidence of DKA in the Jeonbuk population (0.00141%) also exceeded the mean rate (0.0009%).Conclusion: The incidence of pediatric DKA might be higher due to the indirect effect of COVID-19 pandemic. Physicians should be aware of nonspecific symptoms related to DKA in children admitted to the ER.Keywords: coronavirus disease 2019, diabetes, diabetic ketoacidosis, pediatric diabetesHan MJHeo JHDove Medical Pressarticlecoronavirus disease 2019diabetesdiabetic ketoacidosispediatric diabetesSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 783-790 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	coronavirus disease 2019 diabetes diabetic ketoacidosis pediatric diabetes Specialties of internal medicine RC581-951
spellingShingle	coronavirus disease 2019 diabetes diabetic ketoacidosis pediatric diabetes Specialties of internal medicine RC581-951 Han MJ Heo JH Increased Incidence of Pediatric Diabetic Ketoacidosis After COVID-19: A Two-Center Retrospective Study in Korea
description	Min Jeong Han,1 Jun Ho Heo2 1Department of Pediatrics, Chonbuk National University Hospital, Jeonju, 54907, Korea; 2Department of Emergency Medicine, Wonkwang National University Hospital, Iksan, 54887, KoreaCorrespondence: Jun Ho HeoDepartment of Emergency Medicine, Wonkwang National University Hospital, 895, Muwang-Ro, Iksan, 54887, KoreaTel +82-63-8591150Fax +82-63-8592129Email tesaza22@hanmail.netPurpose: We evaluated the clinical characteristics and severity of diabetic ketoacidosis (DKA) in children before and after the coronavirus disease 2019 (COVID-19) outbreak to identify its indirect effects on DKA incidence.Patients and Methods: This retrospective study included 19 children with DKA admitted to the emergency room (ER) in two centers in Jeonbuk province, Korea during the first 6 months of the year from 2017 to 2020. Data were collected on age, height, body weight, clinical symptoms, diabetic mellitus (DM) type, and laboratory findings. DKA severity was based on the presence of acute kidney injury, cerebrovascular accident, and altered mental status. The ratio of patients with DKA in all pediatric patients who visited the study ERs and in the Jeonbuk population was also determined.Results: There were no differences in anthropometric characteristics and complication rates between the pre-COVID-19 and COVID-19 periods; however, the rate of polydipsia was significantly higher in the COVID-19 period. All seven patients admitted during the COVID-19 pandemic (100%) had polydipsia and polyuria and were newly diagnosed with DM. The rate of pediatric patients with DKA admitted to the ER in 2020 (0.459%) was more than twice the mean rate of 0.206% for the four-year period. The incidence of DKA in the Jeonbuk population (0.00141%) also exceeded the mean rate (0.0009%).Conclusion: The incidence of pediatric DKA might be higher due to the indirect effect of COVID-19 pandemic. Physicians should be aware of nonspecific symptoms related to DKA in children admitted to the ER.Keywords: coronavirus disease 2019, diabetes, diabetic ketoacidosis, pediatric diabetes
format	article
author	Han MJ Heo JH
author_facet	Han MJ Heo JH
author_sort	Han MJ
title	Increased Incidence of Pediatric Diabetic Ketoacidosis After COVID-19: A Two-Center Retrospective Study in Korea
title_short	Increased Incidence of Pediatric Diabetic Ketoacidosis After COVID-19: A Two-Center Retrospective Study in Korea
title_full	Increased Incidence of Pediatric Diabetic Ketoacidosis After COVID-19: A Two-Center Retrospective Study in Korea
title_fullStr	Increased Incidence of Pediatric Diabetic Ketoacidosis After COVID-19: A Two-Center Retrospective Study in Korea
title_full_unstemmed	Increased Incidence of Pediatric Diabetic Ketoacidosis After COVID-19: A Two-Center Retrospective Study in Korea
title_sort	increased incidence of pediatric diabetic ketoacidosis after covid-19: a two-center retrospective study in korea
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/c0e06912518742529c4502cf802639e7
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Increased Incidence of Pediatric Diabetic Ketoacidosis After COVID-19: A Two-Center Retrospective Study in Korea

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