Proteomic Research on the Antitumor Properties of Medicinal Mushrooms

Medicinal mushrooms are increasingly being recognized as an important therapeutic modality in complementary oncology. Until now, more than 800 mushroom species have been known to possess significant pharmacological properties, of which antitumor and immunomodulatory properties have been the most res...

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Autores principales:	Boris Jakopovic, Nada Oršolić, Ivan Jakopovich
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cancer medicinal mushrooms proteomics bioinformatics Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/c0e1a1f782564f0faba91207354f3541
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spelling	oai:doaj.org-article:c0e1a1f782564f0faba91207354f35412021-11-11T18:39:24ZProteomic Research on the Antitumor Properties of Medicinal Mushrooms10.3390/molecules262167081420-3049https://doaj.org/article/c0e1a1f782564f0faba91207354f35412021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6708https://doaj.org/toc/1420-3049Medicinal mushrooms are increasingly being recognized as an important therapeutic modality in complementary oncology. Until now, more than 800 mushroom species have been known to possess significant pharmacological properties, of which antitumor and immunomodulatory properties have been the most researched. Besides a number of medicinal mushroom preparations being used as dietary supplements and nutraceuticals, several isolates from mushrooms have been used as official antitumor drugs in clinical settings for several decades. Various proteomic approaches allow for the identification of a large number of differentially regulated proteins serendipitously, thereby providing an important platform for a discovery of new potential therapeutic targets and approaches as well as biomarkers of malignant disease. This review is focused on the current state of proteomic research into antitumor mechanisms of some of the most researched medicinal mushroom species, including <i>Phellinus linteus</i>, <i>Ganoderma lucidum</i>, <i>Auricularia auricula</i>, <i>Agrocybe aegerita</i>, <i>Grifola frondosa</i>, and <i>Lentinus edodes</i>, as whole body extracts or various isolates, as well as of complex extract mixtures.Boris JakopovicNada OršolićIvan JakopovichMDPI AGarticlecancermedicinal mushroomsproteomicsbioinformaticsOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6708, p 6708 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer medicinal mushrooms proteomics bioinformatics Organic chemistry QD241-441
spellingShingle	cancer medicinal mushrooms proteomics bioinformatics Organic chemistry QD241-441 Boris Jakopovic Nada Oršolić Ivan Jakopovich Proteomic Research on the Antitumor Properties of Medicinal Mushrooms
description	Medicinal mushrooms are increasingly being recognized as an important therapeutic modality in complementary oncology. Until now, more than 800 mushroom species have been known to possess significant pharmacological properties, of which antitumor and immunomodulatory properties have been the most researched. Besides a number of medicinal mushroom preparations being used as dietary supplements and nutraceuticals, several isolates from mushrooms have been used as official antitumor drugs in clinical settings for several decades. Various proteomic approaches allow for the identification of a large number of differentially regulated proteins serendipitously, thereby providing an important platform for a discovery of new potential therapeutic targets and approaches as well as biomarkers of malignant disease. This review is focused on the current state of proteomic research into antitumor mechanisms of some of the most researched medicinal mushroom species, including <i>Phellinus linteus</i>, <i>Ganoderma lucidum</i>, <i>Auricularia auricula</i>, <i>Agrocybe aegerita</i>, <i>Grifola frondosa</i>, and <i>Lentinus edodes</i>, as whole body extracts or various isolates, as well as of complex extract mixtures.
format	article
author	Boris Jakopovic Nada Oršolić Ivan Jakopovich
author_facet	Boris Jakopovic Nada Oršolić Ivan Jakopovich
author_sort	Boris Jakopovic
title	Proteomic Research on the Antitumor Properties of Medicinal Mushrooms
title_short	Proteomic Research on the Antitumor Properties of Medicinal Mushrooms
title_full	Proteomic Research on the Antitumor Properties of Medicinal Mushrooms
title_fullStr	Proteomic Research on the Antitumor Properties of Medicinal Mushrooms
title_full_unstemmed	Proteomic Research on the Antitumor Properties of Medicinal Mushrooms
title_sort	proteomic research on the antitumor properties of medicinal mushrooms
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c0e1a1f782564f0faba91207354f3541
work_keys_str_mv	AT borisjakopovic proteomicresearchontheantitumorpropertiesofmedicinalmushrooms AT nadaorsolic proteomicresearchontheantitumorpropertiesofmedicinalmushrooms AT ivanjakopovich proteomicresearchontheantitumorpropertiesofmedicinalmushrooms
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Proteomic Research on the Antitumor Properties of Medicinal Mushrooms

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