Factors influencing SARS-CoV-2 transmission and outbreak control measures in densely populated settings

Abstract Starting with a handful of SARS-CoV-2 infections in dormitory residents in late March 2020, rapid transmission in their dense living environments ensued and by October 2020, more than 50,000 acute infections were identified across various dormitories in Singapore. The aim of the study is to...

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Autores principales:	Rachael Pung, Bernard Lin, Sebastian Maurer-Stroh, Fernanda L. Sirota, Tze Minn Mak, Sophie Octavia, Junxiong Pang, Iain Beehuat Tan, Clive Tan, Biauw Chi Ong, Alex R. Cook, The Singapore COVID-19 Outbreak Research Team, Vernon J. Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c0e2a4b0a27d47368c4ca59e477debe5
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spelling	oai:doaj.org-article:c0e2a4b0a27d47368c4ca59e477debe52021-12-02T18:47:08ZFactors influencing SARS-CoV-2 transmission and outbreak control measures in densely populated settings10.1038/s41598-021-94463-32045-2322https://doaj.org/article/c0e2a4b0a27d47368c4ca59e477debe52021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94463-3https://doaj.org/toc/2045-2322Abstract Starting with a handful of SARS-CoV-2 infections in dormitory residents in late March 2020, rapid transmission in their dense living environments ensued and by October 2020, more than 50,000 acute infections were identified across various dormitories in Singapore. The aim of the study is to identify combination of factors facilitating SARS-CoV-2 transmission and the impact of control measures in a dormitory through extensive epidemiological, serological and phylogenetic investigations, supported by simulation models. Our findings showed that asymptomatic cases and symptomatic cases who did not seek medical attention were major drivers of the outbreak. Furthermore, each resident had about 30 close contacts and each infected resident spread to 4.4 (IQR 3.5–5.3) others at the start of the outbreak. The final attack rate of the current outbreak was 76.2% (IQR 70.6–98.0%) and could be reduced by further 10% under a modified dormitory housing condition. These findings are important when designing living environments in a post COVID-19 future to reduce disease spread and facilitate rapid implementation of outbreak control measures.Rachael PungBernard LinSebastian Maurer-StrohFernanda L. SirotaTze Minn MakSophie OctaviaJunxiong PangIain Beehuat TanClive TanBiauw Chi OngAlex R. CookThe Singapore COVID-19 Outbreak Research TeamVernon J. LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rachael Pung Bernard Lin Sebastian Maurer-Stroh Fernanda L. Sirota Tze Minn Mak Sophie Octavia Junxiong Pang Iain Beehuat Tan Clive Tan Biauw Chi Ong Alex R. Cook The Singapore COVID-19 Outbreak Research Team Vernon J. Lee Factors influencing SARS-CoV-2 transmission and outbreak control measures in densely populated settings
description	Abstract Starting with a handful of SARS-CoV-2 infections in dormitory residents in late March 2020, rapid transmission in their dense living environments ensued and by October 2020, more than 50,000 acute infections were identified across various dormitories in Singapore. The aim of the study is to identify combination of factors facilitating SARS-CoV-2 transmission and the impact of control measures in a dormitory through extensive epidemiological, serological and phylogenetic investigations, supported by simulation models. Our findings showed that asymptomatic cases and symptomatic cases who did not seek medical attention were major drivers of the outbreak. Furthermore, each resident had about 30 close contacts and each infected resident spread to 4.4 (IQR 3.5–5.3) others at the start of the outbreak. The final attack rate of the current outbreak was 76.2% (IQR 70.6–98.0%) and could be reduced by further 10% under a modified dormitory housing condition. These findings are important when designing living environments in a post COVID-19 future to reduce disease spread and facilitate rapid implementation of outbreak control measures.
format	article
author	Rachael Pung Bernard Lin Sebastian Maurer-Stroh Fernanda L. Sirota Tze Minn Mak Sophie Octavia Junxiong Pang Iain Beehuat Tan Clive Tan Biauw Chi Ong Alex R. Cook The Singapore COVID-19 Outbreak Research Team Vernon J. Lee
author_facet	Rachael Pung Bernard Lin Sebastian Maurer-Stroh Fernanda L. Sirota Tze Minn Mak Sophie Octavia Junxiong Pang Iain Beehuat Tan Clive Tan Biauw Chi Ong Alex R. Cook The Singapore COVID-19 Outbreak Research Team Vernon J. Lee
author_sort	Rachael Pung
title	Factors influencing SARS-CoV-2 transmission and outbreak control measures in densely populated settings
title_short	Factors influencing SARS-CoV-2 transmission and outbreak control measures in densely populated settings
title_full	Factors influencing SARS-CoV-2 transmission and outbreak control measures in densely populated settings
title_fullStr	Factors influencing SARS-CoV-2 transmission and outbreak control measures in densely populated settings
title_full_unstemmed	Factors influencing SARS-CoV-2 transmission and outbreak control measures in densely populated settings
title_sort	factors influencing sars-cov-2 transmission and outbreak control measures in densely populated settings
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c0e2a4b0a27d47368c4ca59e477debe5
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Factors influencing SARS-CoV-2 transmission and outbreak control measures in densely populated settings

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