Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations

α-ketoglutarate is an intermediate of the Krebs Cycle that was recently reported to extend lifespan in C.Elegans. Here, the authors show that administration of α-ketoglutarate to mice reduces age-related bone loss, by ameliorating senescence of bone-marrow derived mesenchymal stem cells.

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Autores principales:	Yuan Wang, Peng Deng, Yuting Liu, Yunshu Wu, Yaqian Chen, Yuchen Guo, Shiwen Zhang, Xiaofei Zheng, Liyan Zhou, Weiqing Liu, Qiwen Li, Weimin Lin, Xingying Qi, Guomin Ou, Cunyu Wang, Quan Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c0e3afcbf66046cca618c00251e8fdd0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:c0e3afcbf66046cca618c00251e8fdd02021-12-02T16:56:49ZAlpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations10.1038/s41467-020-19360-12041-1723https://doaj.org/article/c0e3afcbf66046cca618c00251e8fdd02020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19360-1https://doaj.org/toc/2041-1723α-ketoglutarate is an intermediate of the Krebs Cycle that was recently reported to extend lifespan in C.Elegans. Here, the authors show that administration of α-ketoglutarate to mice reduces age-related bone loss, by ameliorating senescence of bone-marrow derived mesenchymal stem cells.Yuan WangPeng DengYuting LiuYunshu WuYaqian ChenYuchen GuoShiwen ZhangXiaofei ZhengLiyan ZhouWeiqing LiuQiwen LiWeimin LinXingying QiGuomin OuCunyu WangQuan YuanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuan Wang Peng Deng Yuting Liu Yunshu Wu Yaqian Chen Yuchen Guo Shiwen Zhang Xiaofei Zheng Liyan Zhou Weiqing Liu Qiwen Li Weimin Lin Xingying Qi Guomin Ou Cunyu Wang Quan Yuan Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations
description	α-ketoglutarate is an intermediate of the Krebs Cycle that was recently reported to extend lifespan in C.Elegans. Here, the authors show that administration of α-ketoglutarate to mice reduces age-related bone loss, by ameliorating senescence of bone-marrow derived mesenchymal stem cells.
format	article
author	Yuan Wang Peng Deng Yuting Liu Yunshu Wu Yaqian Chen Yuchen Guo Shiwen Zhang Xiaofei Zheng Liyan Zhou Weiqing Liu Qiwen Li Weimin Lin Xingying Qi Guomin Ou Cunyu Wang Quan Yuan
author_facet	Yuan Wang Peng Deng Yuting Liu Yunshu Wu Yaqian Chen Yuchen Guo Shiwen Zhang Xiaofei Zheng Liyan Zhou Weiqing Liu Qiwen Li Weimin Lin Xingying Qi Guomin Ou Cunyu Wang Quan Yuan
author_sort	Yuan Wang
title	Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations
title_short	Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations
title_full	Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations
title_fullStr	Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations
title_full_unstemmed	Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations
title_sort	alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c0e3afcbf66046cca618c00251e8fdd0
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Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations

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