Sub-chronic low-dose arsenic in rice exposure induces gut microbiome perturbations in mice

Long-term consumption of arsenic-contaminated rice has become a public health issue that urgently needs to be addressed. In this study, mice were exposed to arsenic in rice (low dose, 0.91 mg/kg; medium dose, 9.1 mg/kg) for 30 days and 60 days, respectively, and the effects on pathological structure...

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Autores principales:	Fubin Chen, Yu Luo, Chengji Li, Jiating Wang, Linkang Chen, Xiaoting Zhong, Bin Zhang, Qijiong Zhu, Rong Zou, Xuming Guo, Yubin Zhou, Lianxian Guo
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Rice arsenic Low-dose Sub-chronic Gut microbiome perturbations Environmental pollution TD172-193.5 Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/c0e53e01fc37401187b1c819883d5e83
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spelling	oai:doaj.org-article:c0e53e01fc37401187b1c819883d5e832021-11-06T04:18:25ZSub-chronic low-dose arsenic in rice exposure induces gut microbiome perturbations in mice0147-651310.1016/j.ecoenv.2021.112934https://doaj.org/article/c0e53e01fc37401187b1c819883d5e832021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0147651321010460https://doaj.org/toc/0147-6513Long-term consumption of arsenic-contaminated rice has become a public health issue that urgently needs to be addressed. In this study, mice were exposed to arsenic in rice (low dose, 0.91 mg/kg; medium dose, 9.1 mg/kg) for 30 days and 60 days, respectively, and the effects on pathological structures of spleen and skin, as well as the structure of the fecal microbiome were examined. The findings revealed dose/time cumulative effects on pathological changes, with even a low dose exposure for 30 days causing destruction of splenic follicular structure and thickening of dermal keratinized and epidermal layers. The Firmicutes/Bacteroidetes ratio in the community and the positive/negative ratio in network links were higher in arsenic groups, suggesting that arsenic resulted in a less healthy and unstable microbiome for the host. Thus lifetime consumption of arsenic in rice may have potential health effects on humans and must be carefully assessed to safeguard human health. Furthermore, in arsenic groups, arsenic-resistant bacteria or arsenic hazards remediation bacteria changed to be the dominant bacteria and acted as the core bacteria in the network modules. Some microbial arsenic transforming genes (arsC, arsR, arsA, ACR3, and aoxB) differed, indicating that the gut microbiome changed to withstand arsenic stress. Furthermore, Faecalibaculum, Lachnospiraceae_NK4A136_group, Angelakisella, Ruminiclostridium, and Desulfovibrionaceae are positively associated with arsenic dosage and may be useful in the early detection of arsenicals.Fubin ChenYu LuoChengji LiJiating WangLinkang ChenXiaoting ZhongBin ZhangQijiong ZhuRong ZouXuming GuoYubin ZhouLianxian GuoElsevierarticleRice arsenicLow-doseSub-chronicGut microbiome perturbationsEnvironmental pollutionTD172-193.5Environmental sciencesGE1-350ENEcotoxicology and Environmental Safety, Vol 227, Iss , Pp 112934- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Rice arsenic Low-dose Sub-chronic Gut microbiome perturbations Environmental pollution TD172-193.5 Environmental sciences GE1-350
spellingShingle	Rice arsenic Low-dose Sub-chronic Gut microbiome perturbations Environmental pollution TD172-193.5 Environmental sciences GE1-350 Fubin Chen Yu Luo Chengji Li Jiating Wang Linkang Chen Xiaoting Zhong Bin Zhang Qijiong Zhu Rong Zou Xuming Guo Yubin Zhou Lianxian Guo Sub-chronic low-dose arsenic in rice exposure induces gut microbiome perturbations in mice
description	Long-term consumption of arsenic-contaminated rice has become a public health issue that urgently needs to be addressed. In this study, mice were exposed to arsenic in rice (low dose, 0.91 mg/kg; medium dose, 9.1 mg/kg) for 30 days and 60 days, respectively, and the effects on pathological structures of spleen and skin, as well as the structure of the fecal microbiome were examined. The findings revealed dose/time cumulative effects on pathological changes, with even a low dose exposure for 30 days causing destruction of splenic follicular structure and thickening of dermal keratinized and epidermal layers. The Firmicutes/Bacteroidetes ratio in the community and the positive/negative ratio in network links were higher in arsenic groups, suggesting that arsenic resulted in a less healthy and unstable microbiome for the host. Thus lifetime consumption of arsenic in rice may have potential health effects on humans and must be carefully assessed to safeguard human health. Furthermore, in arsenic groups, arsenic-resistant bacteria or arsenic hazards remediation bacteria changed to be the dominant bacteria and acted as the core bacteria in the network modules. Some microbial arsenic transforming genes (arsC, arsR, arsA, ACR3, and aoxB) differed, indicating that the gut microbiome changed to withstand arsenic stress. Furthermore, Faecalibaculum, Lachnospiraceae_NK4A136_group, Angelakisella, Ruminiclostridium, and Desulfovibrionaceae are positively associated with arsenic dosage and may be useful in the early detection of arsenicals.
format	article
author	Fubin Chen Yu Luo Chengji Li Jiating Wang Linkang Chen Xiaoting Zhong Bin Zhang Qijiong Zhu Rong Zou Xuming Guo Yubin Zhou Lianxian Guo
author_facet	Fubin Chen Yu Luo Chengji Li Jiating Wang Linkang Chen Xiaoting Zhong Bin Zhang Qijiong Zhu Rong Zou Xuming Guo Yubin Zhou Lianxian Guo
author_sort	Fubin Chen
title	Sub-chronic low-dose arsenic in rice exposure induces gut microbiome perturbations in mice
title_short	Sub-chronic low-dose arsenic in rice exposure induces gut microbiome perturbations in mice
title_full	Sub-chronic low-dose arsenic in rice exposure induces gut microbiome perturbations in mice
title_fullStr	Sub-chronic low-dose arsenic in rice exposure induces gut microbiome perturbations in mice
title_full_unstemmed	Sub-chronic low-dose arsenic in rice exposure induces gut microbiome perturbations in mice
title_sort	sub-chronic low-dose arsenic in rice exposure induces gut microbiome perturbations in mice
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/c0e53e01fc37401187b1c819883d5e83
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Sub-chronic low-dose arsenic in rice exposure induces gut microbiome perturbations in mice

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