Combination of retinoids and narrow-band ultraviolet B inhibits matrix metalloproteinase 13 expression in HaCaT keratinocytes and a mouse model of psoriasis

Abstract Matrix metalloproteinase13 (MMP13) can be released by keratinocytes and fibroblasts and involved in the pathogenesis of skin disorders. Retinoic acid derivative drugs include tazarotene and acitretin. Tazarotene/acitretin and narrow-band ultraviolet B (NB-UVB) irradiation are common treatme...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chan Xi, Chuanxi Xiong, Huiping Wang, Yuanjun Liu, Suju Luo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c0e55550661a48d2bf8c016d9d55a65d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c0e55550661a48d2bf8c016d9d55a65d
record_format	dspace
spelling	oai:doaj.org-article:c0e55550661a48d2bf8c016d9d55a65d2021-12-02T18:02:49ZCombination of retinoids and narrow-band ultraviolet B inhibits matrix metalloproteinase 13 expression in HaCaT keratinocytes and a mouse model of psoriasis10.1038/s41598-021-92599-w2045-2322https://doaj.org/article/c0e55550661a48d2bf8c016d9d55a65d2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92599-whttps://doaj.org/toc/2045-2322Abstract Matrix metalloproteinase13 (MMP13) can be released by keratinocytes and fibroblasts and involved in the pathogenesis of skin disorders. Retinoic acid derivative drugs include tazarotene and acitretin. Tazarotene/acitretin and narrow-band ultraviolet B (NB-UVB) irradiation are common treatment options for psoriasis. However, their impact on MMP13 expression in the context of psoriasis has yet to be determined. The expression of MMP13 was analyzed in patients with psoriasis. The effects of tazarotene/acitretin and NB-UVB on MMP13 expression were also investigated in a mouse model of psoriasis. Human HaCaT keratinocytes were exposed to acitretin or NB-UVB and then assayed for cell proliferation and MMP13 expression levels. We showed that patients with psoriasis had increased levels of MMP13 protein in skin lesions and serum samples. Exposure to acitretin and NB-UVB irradiation alone or in combination led to reduction of cell proliferation and MMP13 expression in HaCaT cells. Consistently, tazarotene treatment or NB-UVB irradiation attenuated imiquimod-induced psoriasis-like dermatitis and decreased MMP13 expression in a mouse model. Based on these from HaCaT keratinocytes cells and animal experiments, we suggest that tazarotene/acitretin and NB-UVB irradiation can inhibit the expression of MMP13 in HaCaT keratinocytes and psoriasis mouse models. Blockade of MMP13 activity may have therapeutic potential in improving symptoms of psoriasis.Chan XiChuanxi XiongHuiping WangYuanjun LiuSuju LuoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chan Xi Chuanxi Xiong Huiping Wang Yuanjun Liu Suju Luo Combination of retinoids and narrow-band ultraviolet B inhibits matrix metalloproteinase 13 expression in HaCaT keratinocytes and a mouse model of psoriasis
description	Abstract Matrix metalloproteinase13 (MMP13) can be released by keratinocytes and fibroblasts and involved in the pathogenesis of skin disorders. Retinoic acid derivative drugs include tazarotene and acitretin. Tazarotene/acitretin and narrow-band ultraviolet B (NB-UVB) irradiation are common treatment options for psoriasis. However, their impact on MMP13 expression in the context of psoriasis has yet to be determined. The expression of MMP13 was analyzed in patients with psoriasis. The effects of tazarotene/acitretin and NB-UVB on MMP13 expression were also investigated in a mouse model of psoriasis. Human HaCaT keratinocytes were exposed to acitretin or NB-UVB and then assayed for cell proliferation and MMP13 expression levels. We showed that patients with psoriasis had increased levels of MMP13 protein in skin lesions and serum samples. Exposure to acitretin and NB-UVB irradiation alone or in combination led to reduction of cell proliferation and MMP13 expression in HaCaT cells. Consistently, tazarotene treatment or NB-UVB irradiation attenuated imiquimod-induced psoriasis-like dermatitis and decreased MMP13 expression in a mouse model. Based on these from HaCaT keratinocytes cells and animal experiments, we suggest that tazarotene/acitretin and NB-UVB irradiation can inhibit the expression of MMP13 in HaCaT keratinocytes and psoriasis mouse models. Blockade of MMP13 activity may have therapeutic potential in improving symptoms of psoriasis.
format	article
author	Chan Xi Chuanxi Xiong Huiping Wang Yuanjun Liu Suju Luo
author_facet	Chan Xi Chuanxi Xiong Huiping Wang Yuanjun Liu Suju Luo
author_sort	Chan Xi
title	Combination of retinoids and narrow-band ultraviolet B inhibits matrix metalloproteinase 13 expression in HaCaT keratinocytes and a mouse model of psoriasis
title_short	Combination of retinoids and narrow-band ultraviolet B inhibits matrix metalloproteinase 13 expression in HaCaT keratinocytes and a mouse model of psoriasis
title_full	Combination of retinoids and narrow-band ultraviolet B inhibits matrix metalloproteinase 13 expression in HaCaT keratinocytes and a mouse model of psoriasis
title_fullStr	Combination of retinoids and narrow-band ultraviolet B inhibits matrix metalloproteinase 13 expression in HaCaT keratinocytes and a mouse model of psoriasis
title_full_unstemmed	Combination of retinoids and narrow-band ultraviolet B inhibits matrix metalloproteinase 13 expression in HaCaT keratinocytes and a mouse model of psoriasis
title_sort	combination of retinoids and narrow-band ultraviolet b inhibits matrix metalloproteinase 13 expression in hacat keratinocytes and a mouse model of psoriasis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c0e55550661a48d2bf8c016d9d55a65d
work_keys_str_mv	AT chanxi combinationofretinoidsandnarrowbandultravioletbinhibitsmatrixmetalloproteinase13expressioninhacatkeratinocytesandamousemodelofpsoriasis AT chuanxixiong combinationofretinoidsandnarrowbandultravioletbinhibitsmatrixmetalloproteinase13expressioninhacatkeratinocytesandamousemodelofpsoriasis AT huipingwang combinationofretinoidsandnarrowbandultravioletbinhibitsmatrixmetalloproteinase13expressioninhacatkeratinocytesandamousemodelofpsoriasis AT yuanjunliu combinationofretinoidsandnarrowbandultravioletbinhibitsmatrixmetalloproteinase13expressioninhacatkeratinocytesandamousemodelofpsoriasis AT sujuluo combinationofretinoidsandnarrowbandultravioletbinhibitsmatrixmetalloproteinase13expressioninhacatkeratinocytesandamousemodelofpsoriasis
_version_	1718378893913620480

Combination of retinoids and narrow-band ultraviolet B inhibits matrix metalloproteinase 13 expression in HaCaT keratinocytes and a mouse model of psoriasis

Ejemplares similares