L-selectin mechanochemistry restricts neutrophil priming in vivo

Neutrophil adhesion is tightly regulated to enforce protective immunity, but it is unclear how mechanochemical processes such as catch bonds and slip bonds modulate neutrophilsin vivo. Here the authors show that a point mutation in the adhesion molecule L-selectin alters mechanochemical regulation t...

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Autores principales:	Zhenghui Liu, Tadayuki Yago, Nan Zhang, Sumith R. Panicker, Ying Wang, Longbiao Yao, Padmaja Mehta-D’souza, Lijun Xia, Cheng Zhu, Rodger P. McEver
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c0e7f746127e4600a846c356bdd5181b
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spelling	oai:doaj.org-article:c0e7f746127e4600a846c356bdd5181b2021-12-02T15:38:39ZL-selectin mechanochemistry restricts neutrophil priming in vivo10.1038/ncomms151962041-1723https://doaj.org/article/c0e7f746127e4600a846c356bdd5181b2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15196https://doaj.org/toc/2041-1723Neutrophil adhesion is tightly regulated to enforce protective immunity, but it is unclear how mechanochemical processes such as catch bonds and slip bonds modulate neutrophilsin vivo. Here the authors show that a point mutation in the adhesion molecule L-selectin alters mechanochemical regulation to affect neutrophil functions in mice.Zhenghui LiuTadayuki YagoNan ZhangSumith R. PanickerYing WangLongbiao YaoPadmaja Mehta-D’souzaLijun XiaCheng ZhuRodger P. McEverNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhenghui Liu Tadayuki Yago Nan Zhang Sumith R. Panicker Ying Wang Longbiao Yao Padmaja Mehta-D’souza Lijun Xia Cheng Zhu Rodger P. McEver L-selectin mechanochemistry restricts neutrophil priming in vivo
description	Neutrophil adhesion is tightly regulated to enforce protective immunity, but it is unclear how mechanochemical processes such as catch bonds and slip bonds modulate neutrophilsin vivo. Here the authors show that a point mutation in the adhesion molecule L-selectin alters mechanochemical regulation to affect neutrophil functions in mice.
format	article
author	Zhenghui Liu Tadayuki Yago Nan Zhang Sumith R. Panicker Ying Wang Longbiao Yao Padmaja Mehta-D’souza Lijun Xia Cheng Zhu Rodger P. McEver
author_facet	Zhenghui Liu Tadayuki Yago Nan Zhang Sumith R. Panicker Ying Wang Longbiao Yao Padmaja Mehta-D’souza Lijun Xia Cheng Zhu Rodger P. McEver
author_sort	Zhenghui Liu
title	L-selectin mechanochemistry restricts neutrophil priming in vivo
title_short	L-selectin mechanochemistry restricts neutrophil priming in vivo
title_full	L-selectin mechanochemistry restricts neutrophil priming in vivo
title_fullStr	L-selectin mechanochemistry restricts neutrophil priming in vivo
title_full_unstemmed	L-selectin mechanochemistry restricts neutrophil priming in vivo
title_sort	l-selectin mechanochemistry restricts neutrophil priming in vivo
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c0e7f746127e4600a846c356bdd5181b
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L-selectin mechanochemistry restricts neutrophil priming in vivo

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