Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome

The human congenital disorder Noonan Syndrome (NS) is caused by germ-line mutations that hyperactivate the RAS/ERK signalling pathway, and can feature pathologic cardiac enlargement. Here, the authors find that a complex cellular and molecular interplay involving a cytokine hierarchy underlies cardi...

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Autores principales:	Jiani C. Yin, Mathew J. Platt, Xixi Tian, Xue Wu, Peter H. Backx, Jeremy A. Simpson, Toshiyuki Araki, Benjamin G. Neel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c0ef656506ad478fa179f7ccc1274124
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spelling	oai:doaj.org-article:c0ef656506ad478fa179f7ccc12741242021-12-02T14:41:20ZCellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome10.1038/ncomms155182041-1723https://doaj.org/article/c0ef656506ad478fa179f7ccc12741242017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15518https://doaj.org/toc/2041-1723The human congenital disorder Noonan Syndrome (NS) is caused by germ-line mutations that hyperactivate the RAS/ERK signalling pathway, and can feature pathologic cardiac enlargement. Here, the authors find that a complex cellular and molecular interplay involving a cytokine hierarchy underlies cardiac hypertrophy caused by a NS-associatedRafallele.Jiani C. YinMathew J. PlattXixi TianXue WuPeter H. BackxJeremy A. SimpsonToshiyuki ArakiBenjamin G. NeelNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiani C. Yin Mathew J. Platt Xixi Tian Xue Wu Peter H. Backx Jeremy A. Simpson Toshiyuki Araki Benjamin G. Neel Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome
description	The human congenital disorder Noonan Syndrome (NS) is caused by germ-line mutations that hyperactivate the RAS/ERK signalling pathway, and can feature pathologic cardiac enlargement. Here, the authors find that a complex cellular and molecular interplay involving a cytokine hierarchy underlies cardiac hypertrophy caused by a NS-associatedRafallele.
format	article
author	Jiani C. Yin Mathew J. Platt Xixi Tian Xue Wu Peter H. Backx Jeremy A. Simpson Toshiyuki Araki Benjamin G. Neel
author_facet	Jiani C. Yin Mathew J. Platt Xixi Tian Xue Wu Peter H. Backx Jeremy A. Simpson Toshiyuki Araki Benjamin G. Neel
author_sort	Jiani C. Yin
title	Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome
title_short	Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome
title_full	Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome
title_fullStr	Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome
title_full_unstemmed	Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome
title_sort	cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in raf1-mutant noonan syndrome
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c0ef656506ad478fa179f7ccc1274124
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Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome

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