Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome
The human congenital disorder Noonan Syndrome (NS) is caused by germ-line mutations that hyperactivate the RAS/ERK signalling pathway, and can feature pathologic cardiac enlargement. Here, the authors find that a complex cellular and molecular interplay involving a cytokine hierarchy underlies cardi...
Guardado en:
Autores principales: | Jiani C. Yin, Mathew J. Platt, Xixi Tian, Xue Wu, Peter H. Backx, Jeremy A. Simpson, Toshiyuki Araki, Benjamin G. Neel |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/c0ef656506ad478fa179f7ccc1274124 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition
por: Ting Jin, et al.
Publicado: (2017) -
Interplay between structural hierarchy and exciton diffusion in artificial light harvesting
por: Björn Kriete, et al.
Publicado: (2019) -
SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers
por: Greg G. Jones, et al.
Publicado: (2019) -
GH Responsiveness in Children With Noonan Syndrome Compared to Turner Syndrome
por: Jovanna Dahlgren, et al.
Publicado: (2021) -
['Dental Care in an adolescent female with Noonan Syndrome: A Case Report', 'Atención Odontológica en una adolescente con Síndrome de Noonan: Reporte de un caso', 'Assistência odontológica em adolescente com Síndrome de Noonan: Relato de caso']
por: Fernanda Gonzalez, et al.
Publicado: (2021)