Transcranial magnetic stimulation for treating depression in elderly patients

Gokben Hizli Sayar, Eylem Ozten, Oguz Tan, Nevzat Tarhan Uskudar University, Neuropsychiatry Istanbul Hospital, Department of Psychiatry, Istanbul, Turkey Purpose: The aim of the study reported here was to examine the safety and effectiveness of high-frequency repetitive transcranial magnetic stimul...

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Autores principales:	Hizli Sayar G, Ozten E, Tan O, Tarhan N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/c0f15c7da88c4b26a1af213a67f01597
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spelling	oai:doaj.org-article:c0f15c7da88c4b26a1af213a67f015972021-12-02T02:21:12ZTranscranial magnetic stimulation for treating depression in elderly patients1176-63281178-2021https://doaj.org/article/c0f15c7da88c4b26a1af213a67f015972013-04-01T00:00:00Zhttp://www.dovepress.com/transcranial-magnetic-stimulation-for-treating-depression-in-elderly-p-a12758https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Gokben Hizli Sayar, Eylem Ozten, Oguz Tan, Nevzat Tarhan Uskudar University, Neuropsychiatry Istanbul Hospital, Department of Psychiatry, Istanbul, Turkey Purpose: The aim of the study reported here was to examine the safety and effectiveness of high-frequency repetitive transcranial magnetic stimulation (rTMS) in elderly patients with depression. Patients and methods: Sixty-five depressed elderly patients received rTMS over their left prefrontal cortex for 6 days per week, from Monday to Saturday, for 3 weeks. The rTMS intensity was set at 100% of the motor threshold and 25 Hz stimulation with a duration of 2 seconds and was delivered 20 times at 30-second intervals. A full course comprised an average of 1000 magnetic pulses. Depression was rated using the Hamilton Depression Rating Scale (HAMD) before and after treatment. Response was defined as a 50% reduction in HAMD score. Patients with HAMD scores < 8 were considered to be in remission. Results: The mean HAMD score for the study group decreased from 21.94 ± 5.12 before treatment to 11.28 ± 4.56 after rTMS (P < 0.001). Following the treatment period, 58.46% of the study group demonstrated significant mood improvement, as indexed by a reduction of more than 50% on the HAMD score. Nineteen of these 38 patients attained remission (HAMD score < 8), while 41.54% of all study patients achieved a partial response. None of the patients had a worsened HAMD score at the end of the treatment. Treatment was generally well tolerated and no serious adverse effects were reported. Conclusion: In this study, rTMS was found to be a safe, well-tolerated treatment, and a useful adjunctive treatment to medications in elderly treatment-resistant depressed patients. This study contributes to the existing evidence on the antidepressant effect of rTMS in the treatment of depression in patients over 60 years of age. Keywords: high-frequency repetitive TMS, rTMS, Hamilton Depression Rating ScaleHizli Sayar GOzten ETan OTarhan NDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 501-504 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Hizli Sayar G Ozten E Tan O Tarhan N Transcranial magnetic stimulation for treating depression in elderly patients
description	Gokben Hizli Sayar, Eylem Ozten, Oguz Tan, Nevzat Tarhan Uskudar University, Neuropsychiatry Istanbul Hospital, Department of Psychiatry, Istanbul, Turkey Purpose: The aim of the study reported here was to examine the safety and effectiveness of high-frequency repetitive transcranial magnetic stimulation (rTMS) in elderly patients with depression. Patients and methods: Sixty-five depressed elderly patients received rTMS over their left prefrontal cortex for 6 days per week, from Monday to Saturday, for 3 weeks. The rTMS intensity was set at 100% of the motor threshold and 25 Hz stimulation with a duration of 2 seconds and was delivered 20 times at 30-second intervals. A full course comprised an average of 1000 magnetic pulses. Depression was rated using the Hamilton Depression Rating Scale (HAMD) before and after treatment. Response was defined as a 50% reduction in HAMD score. Patients with HAMD scores < 8 were considered to be in remission. Results: The mean HAMD score for the study group decreased from 21.94 ± 5.12 before treatment to 11.28 ± 4.56 after rTMS (P < 0.001). Following the treatment period, 58.46% of the study group demonstrated significant mood improvement, as indexed by a reduction of more than 50% on the HAMD score. Nineteen of these 38 patients attained remission (HAMD score < 8), while 41.54% of all study patients achieved a partial response. None of the patients had a worsened HAMD score at the end of the treatment. Treatment was generally well tolerated and no serious adverse effects were reported. Conclusion: In this study, rTMS was found to be a safe, well-tolerated treatment, and a useful adjunctive treatment to medications in elderly treatment-resistant depressed patients. This study contributes to the existing evidence on the antidepressant effect of rTMS in the treatment of depression in patients over 60 years of age. Keywords: high-frequency repetitive TMS, rTMS, Hamilton Depression Rating Scale
format	article
author	Hizli Sayar G Ozten E Tan O Tarhan N
author_facet	Hizli Sayar G Ozten E Tan O Tarhan N
author_sort	Hizli Sayar G
title	Transcranial magnetic stimulation for treating depression in elderly patients
title_short	Transcranial magnetic stimulation for treating depression in elderly patients
title_full	Transcranial magnetic stimulation for treating depression in elderly patients
title_fullStr	Transcranial magnetic stimulation for treating depression in elderly patients
title_full_unstemmed	Transcranial magnetic stimulation for treating depression in elderly patients
title_sort	transcranial magnetic stimulation for treating depression in elderly patients
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/c0f15c7da88c4b26a1af213a67f01597
work_keys_str_mv	AT hizlisayarg transcranialmagneticstimulationfortreatingdepressioninelderlypatients AT oztene transcranialmagneticstimulationfortreatingdepressioninelderlypatients AT tano transcranialmagneticstimulationfortreatingdepressioninelderlypatients AT tarhann transcranialmagneticstimulationfortreatingdepressioninelderlypatients
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Transcranial magnetic stimulation for treating depression in elderly patients

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