THE ROLE OF CYTOKINE GENES POLYMORPHISM IN HEPATITIS C VIRUS INFECTION

Abstract. The outcome of hepatitis C virus (HCV) infection depends on the immune response caused by the host genetic factors. Cytokines are key mediators of inflammation and development of specific immunity, which is responsible for the elimination of HCV. It has been found that the polymorphisms in...

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Autores principales:	N. A. Arsentieva, A. V. Semenov, Areg A. Totolian
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	hepatitis c virus cytokines single nucleotide polymorphisms Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/c0f1965d33354c769558214b49a068e0
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spelling	oai:doaj.org-article:c0f1965d33354c769558214b49a068e02021-11-22T07:09:46ZTHE ROLE OF CYTOKINE GENES POLYMORPHISM IN HEPATITIS C VIRUS INFECTION2220-76192313-739810.15789/2220-7619-2012-4-687-698https://doaj.org/article/c0f1965d33354c769558214b49a068e02014-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/105https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. The outcome of hepatitis C virus (HCV) infection depends on the immune response caused by the host genetic factors. Cytokines are key mediators of inflammation and development of specific immunity, which is responsible for the elimination of HCV. It has been found that the polymorphisms in several cytokine genes play role in human susceptibility to HCV infection, determine its differences in response to HCV and treatment-induced HCV clearance. This review summarizes the results of studies on the single-nucleotide polymorphisms of cytokine genes that complete our knowledge of the pathogenesis of HCV infection.N. A. ArsentievaA. V. SemenovAreg A. TotolianSankt-Peterburg : NIIÈM imeni Pasteraarticlehepatitis c viruscytokinessingle nucleotide polymorphismsInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 2, Iss 4, Pp 687-698 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	hepatitis c virus cytokines single nucleotide polymorphisms Infectious and parasitic diseases RC109-216
spellingShingle	hepatitis c virus cytokines single nucleotide polymorphisms Infectious and parasitic diseases RC109-216 N. A. Arsentieva A. V. Semenov Areg A. Totolian THE ROLE OF CYTOKINE GENES POLYMORPHISM IN HEPATITIS C VIRUS INFECTION
description	Abstract. The outcome of hepatitis C virus (HCV) infection depends on the immune response caused by the host genetic factors. Cytokines are key mediators of inflammation and development of specific immunity, which is responsible for the elimination of HCV. It has been found that the polymorphisms in several cytokine genes play role in human susceptibility to HCV infection, determine its differences in response to HCV and treatment-induced HCV clearance. This review summarizes the results of studies on the single-nucleotide polymorphisms of cytokine genes that complete our knowledge of the pathogenesis of HCV infection.
format	article
author	N. A. Arsentieva A. V. Semenov Areg A. Totolian
author_facet	N. A. Arsentieva A. V. Semenov Areg A. Totolian
author_sort	N. A. Arsentieva
title	THE ROLE OF CYTOKINE GENES POLYMORPHISM IN HEPATITIS C VIRUS INFECTION
title_short	THE ROLE OF CYTOKINE GENES POLYMORPHISM IN HEPATITIS C VIRUS INFECTION
title_full	THE ROLE OF CYTOKINE GENES POLYMORPHISM IN HEPATITIS C VIRUS INFECTION
title_fullStr	THE ROLE OF CYTOKINE GENES POLYMORPHISM IN HEPATITIS C VIRUS INFECTION
title_full_unstemmed	THE ROLE OF CYTOKINE GENES POLYMORPHISM IN HEPATITIS C VIRUS INFECTION
title_sort	role of cytokine genes polymorphism in hepatitis c virus infection
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/c0f1965d33354c769558214b49a068e0
work_keys_str_mv	AT naarsentieva theroleofcytokinegenespolymorphisminhepatitiscvirusinfection AT avsemenov theroleofcytokinegenespolymorphisminhepatitiscvirusinfection AT aregatotolian theroleofcytokinegenespolymorphisminhepatitiscvirusinfection AT naarsentieva roleofcytokinegenespolymorphisminhepatitiscvirusinfection AT avsemenov roleofcytokinegenespolymorphisminhepatitiscvirusinfection AT aregatotolian roleofcytokinegenespolymorphisminhepatitiscvirusinfection
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THE ROLE OF CYTOKINE GENES POLYMORPHISM IN HEPATITIS C VIRUS INFECTION

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