Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution

Women with germline variants in BRCA genes are predisposed to ovarian cancer. In this study, the authors demonstrate that fimbrial tissue from the ovary, the site of ovarian cancer, in BRCAmutant carriers contains marked DNA methylation changes compared with the proximal region of the ovary.

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Autores principales:	Thomas E. Bartlett, Kantaraja Chindera, Jacqueline McDermott, Charles E. Breeze, William R. Cooke, Allison Jones, Daniel Reisel, Smita T. Karegodar, Rupali Arora, Stephan Beck, Usha Menon, Louis Dubeau, Martin Widschwendter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c0f2825e826f439a82d6b3c7a397ac25
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spelling	oai:doaj.org-article:c0f2825e826f439a82d6b3c7a397ac252021-12-02T15:33:49ZEpigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution10.1038/ncomms116202041-1723https://doaj.org/article/c0f2825e826f439a82d6b3c7a397ac252016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11620https://doaj.org/toc/2041-1723Women with germline variants in BRCA genes are predisposed to ovarian cancer. In this study, the authors demonstrate that fimbrial tissue from the ovary, the site of ovarian cancer, in BRCAmutant carriers contains marked DNA methylation changes compared with the proximal region of the ovary.Thomas E. BartlettKantaraja ChinderaJacqueline McDermottCharles E. BreezeWilliam R. CookeAllison JonesDaniel ReiselSmita T. KaregodarRupali AroraStephan BeckUsha MenonLouis DubeauMartin WidschwendterNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas E. Bartlett Kantaraja Chindera Jacqueline McDermott Charles E. Breeze William R. Cooke Allison Jones Daniel Reisel Smita T. Karegodar Rupali Arora Stephan Beck Usha Menon Louis Dubeau Martin Widschwendter Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution
description	Women with germline variants in BRCA genes are predisposed to ovarian cancer. In this study, the authors demonstrate that fimbrial tissue from the ovary, the site of ovarian cancer, in BRCAmutant carriers contains marked DNA methylation changes compared with the proximal region of the ovary.
format	article
author	Thomas E. Bartlett Kantaraja Chindera Jacqueline McDermott Charles E. Breeze William R. Cooke Allison Jones Daniel Reisel Smita T. Karegodar Rupali Arora Stephan Beck Usha Menon Louis Dubeau Martin Widschwendter
author_facet	Thomas E. Bartlett Kantaraja Chindera Jacqueline McDermott Charles E. Breeze William R. Cooke Allison Jones Daniel Reisel Smita T. Karegodar Rupali Arora Stephan Beck Usha Menon Louis Dubeau Martin Widschwendter
author_sort	Thomas E. Bartlett
title	Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution
title_short	Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution
title_full	Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution
title_fullStr	Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution
title_full_unstemmed	Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution
title_sort	epigenetic reprogramming of fallopian tube fimbriae in brca mutation carriers defines early ovarian cancer evolution
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c0f2825e826f439a82d6b3c7a397ac25
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Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution

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