Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution

Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution

Women with germline variants in BRCA genes are predisposed to ovarian cancer. In this study, the authors demonstrate that fimbrial tissue from the ovary, the site of ovarian cancer, in BRCAmutant carriers contains marked DNA methylation changes compared with the proximal region of the ovary.

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Detalles Bibliográficos
Autores principales: Thomas E. Bartlett, Kantaraja Chindera, Jacqueline McDermott, Charles E. Breeze, William R. Cooke, Allison Jones, Daniel Reisel, Smita T. Karegodar, Rupali Arora, Stephan Beck, Usha Menon, Louis Dubeau, Martin Widschwendter
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
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Acceso en línea:https://doaj.org/article/c0f2825e826f439a82d6b3c7a397ac25
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