Surviving Sepsis Campaign: Research Opportunities for Infection and Blood Purification Therapies

OBJECTIVES:. Patients with infection can develop sepsis, and their mortality can be high. An important aspect in the treatment of sepsis is adequate management of the infection. DATA SOURCES:. Using a modified Delphi approach, the Surviving Sepsis Campaign research committee recently published a ser...

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Autores principales:	Ignacio Martin-Loeches, MD, PhD, JFICMI, Mark E. Nunnally, MD, FCCM, Judith Hellman, MD, Ishaq Lat, PharmD, FCCM, Greg S. Martin, MD, FCCM, Sameer Jog, MD, Jozef Kesecioglu, MD, PhD, Daniel De Backer, MD, PhD, Craig M. Coopersmith, MD, MCCM, For the Research Committee of the Surviving Sepsis Campaign, Ignacio Martin-Loeches, Craig M. Coopersmith, Daniel De Backer, Clifford S Deutschman, Ricard Ferrer-Roca, Judith Hellman, Sameer Jog, Ishaq Lat, Flavia Machado, Greg Martin, Mark E. Nunnally
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer 2021
Materias:	Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
Acceso en línea:	https://doaj.org/article/c0f7d79c1cf142d9ad26c5cbb1a4d4c7
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spelling	oai:doaj.org-article:c0f7d79c1cf142d9ad26c5cbb1a4d4c72021-11-25T07:56:23ZSurviving Sepsis Campaign: Research Opportunities for Infection and Blood Purification Therapies2639-802810.1097/CCE.0000000000000511https://doaj.org/article/c0f7d79c1cf142d9ad26c5cbb1a4d4c72021-09-01T00:00:00Zhttp://journals.lww.com/10.1097/CCE.0000000000000511https://doaj.org/toc/2639-8028OBJECTIVES:. Patients with infection can develop sepsis, and their mortality can be high. An important aspect in the treatment of sepsis is adequate management of the infection. DATA SOURCES:. Using a modified Delphi approach, the Surviving Sepsis Campaign research committee recently published a series of 26 priorities for sepsis and septic shock. STUDY SELECTION:. Task force members with specific expertise were tasked with generating expanded reviews for all infection questions and a subset of adjunctive therapy questions from the larger list of sepsis priorities. Each question was addressed by one of the six task force members. DATA EXTRACTION:. In-depth reviews were then edited by the group as a whole, with added input from the committee cochairs. DATA SYNTHESIS:. Six questions were addressed: 1) should empiric antibiotic combination therapy be used in sepsis or septic shock? 2) does optimization of antimicrobial pharmacokinetics and pharmacodynamics impact patient outcomes in sepsis? 3) should viral reactivation resulting from sepsis-induced immunosuppression be treated with antiviral therapy in critically ill septic patients? 4) should rapid diagnostic tests be implemented in clinical practice? 5) what is the role of lung-protective ventilation in sepsis patients without acute respiratory distress syndrome? and 6) how do we determine the efficacy of “blood purification” therapies such as endotoxin absorbers, cytokine absorbers, and plasmapheresis. CONCLUSIONS:. The research committee members for the Surviving Sepsis Campaign aimed to explore research questions in order to provide existing evidence and highlight areas of uncertainty and future directions.Ignacio Martin-Loeches, MD, PhD, JFICMIMark E. Nunnally, MD, FCCMJudith Hellman, MDIshaq Lat, PharmD, FCCMGreg S. Martin, MD, FCCMSameer Jog, MDJozef Kesecioglu, MD, PhDDaniel De Backer, MD, PhDCraig M. Coopersmith, MD, MCCMFor the Research Committee of the Surviving Sepsis CampaignIgnacio Martin-LoechesCraig M. CoopersmithDaniel De BackerClifford S DeutschmanRicard Ferrer-RocaJudith HellmanSameer JogIshaq LatFlavia MachadoGreg MartinMark E. NunnallyWolters KluwerarticleMedical emergencies. Critical care. Intensive care. First aidRC86-88.9ENCritical Care Explorations, Vol 3, Iss 9, p e0511 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
spellingShingle	Medical emergencies. Critical care. Intensive care. First aid RC86-88.9 Ignacio Martin-Loeches, MD, PhD, JFICMI Mark E. Nunnally, MD, FCCM Judith Hellman, MD Ishaq Lat, PharmD, FCCM Greg S. Martin, MD, FCCM Sameer Jog, MD Jozef Kesecioglu, MD, PhD Daniel De Backer, MD, PhD Craig M. Coopersmith, MD, MCCM For the Research Committee of the Surviving Sepsis Campaign Ignacio Martin-Loeches Craig M. Coopersmith Daniel De Backer Clifford S Deutschman Ricard Ferrer-Roca Judith Hellman Sameer Jog Ishaq Lat Flavia Machado Greg Martin Mark E. Nunnally Surviving Sepsis Campaign: Research Opportunities for Infection and Blood Purification Therapies
description	OBJECTIVES:. Patients with infection can develop sepsis, and their mortality can be high. An important aspect in the treatment of sepsis is adequate management of the infection. DATA SOURCES:. Using a modified Delphi approach, the Surviving Sepsis Campaign research committee recently published a series of 26 priorities for sepsis and septic shock. STUDY SELECTION:. Task force members with specific expertise were tasked with generating expanded reviews for all infection questions and a subset of adjunctive therapy questions from the larger list of sepsis priorities. Each question was addressed by one of the six task force members. DATA EXTRACTION:. In-depth reviews were then edited by the group as a whole, with added input from the committee cochairs. DATA SYNTHESIS:. Six questions were addressed: 1) should empiric antibiotic combination therapy be used in sepsis or septic shock? 2) does optimization of antimicrobial pharmacokinetics and pharmacodynamics impact patient outcomes in sepsis? 3) should viral reactivation resulting from sepsis-induced immunosuppression be treated with antiviral therapy in critically ill septic patients? 4) should rapid diagnostic tests be implemented in clinical practice? 5) what is the role of lung-protective ventilation in sepsis patients without acute respiratory distress syndrome? and 6) how do we determine the efficacy of “blood purification” therapies such as endotoxin absorbers, cytokine absorbers, and plasmapheresis. CONCLUSIONS:. The research committee members for the Surviving Sepsis Campaign aimed to explore research questions in order to provide existing evidence and highlight areas of uncertainty and future directions.
format	article
author	Ignacio Martin-Loeches, MD, PhD, JFICMI Mark E. Nunnally, MD, FCCM Judith Hellman, MD Ishaq Lat, PharmD, FCCM Greg S. Martin, MD, FCCM Sameer Jog, MD Jozef Kesecioglu, MD, PhD Daniel De Backer, MD, PhD Craig M. Coopersmith, MD, MCCM For the Research Committee of the Surviving Sepsis Campaign Ignacio Martin-Loeches Craig M. Coopersmith Daniel De Backer Clifford S Deutschman Ricard Ferrer-Roca Judith Hellman Sameer Jog Ishaq Lat Flavia Machado Greg Martin Mark E. Nunnally
author_facet	Ignacio Martin-Loeches, MD, PhD, JFICMI Mark E. Nunnally, MD, FCCM Judith Hellman, MD Ishaq Lat, PharmD, FCCM Greg S. Martin, MD, FCCM Sameer Jog, MD Jozef Kesecioglu, MD, PhD Daniel De Backer, MD, PhD Craig M. Coopersmith, MD, MCCM For the Research Committee of the Surviving Sepsis Campaign Ignacio Martin-Loeches Craig M. Coopersmith Daniel De Backer Clifford S Deutschman Ricard Ferrer-Roca Judith Hellman Sameer Jog Ishaq Lat Flavia Machado Greg Martin Mark E. Nunnally
author_sort	Ignacio Martin-Loeches, MD, PhD, JFICMI
title	Surviving Sepsis Campaign: Research Opportunities for Infection and Blood Purification Therapies
title_short	Surviving Sepsis Campaign: Research Opportunities for Infection and Blood Purification Therapies
title_full	Surviving Sepsis Campaign: Research Opportunities for Infection and Blood Purification Therapies
title_fullStr	Surviving Sepsis Campaign: Research Opportunities for Infection and Blood Purification Therapies
title_full_unstemmed	Surviving Sepsis Campaign: Research Opportunities for Infection and Blood Purification Therapies
title_sort	surviving sepsis campaign: research opportunities for infection and blood purification therapies
publisher	Wolters Kluwer
publishDate	2021
url	https://doaj.org/article/c0f7d79c1cf142d9ad26c5cbb1a4d4c7
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Surviving Sepsis Campaign: Research Opportunities for Infection and Blood Purification Therapies

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