Diagnostic performance and characteristics of anterior nasal collection for the SARS-CoV-2 antigen test: a prospective study

Abstract The clinical utility of antigen test using anterior nasal samples has not been well evaluated. We conducted a prospective study in a drive-through testing site located at a PCR center to evaluate the diagnostic performance of the antigen test QuickNavi-COVID19 Ag using anterior nasal sample...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yuto Takeuchi, Yusaku Akashi, Daisuke Kato, Miwa Kuwahara, Shino Muramatsu, Atsuo Ueda, Shigeyuki Notake, Koji Nakamura, Hiroichi Ishikawa, Hiromichi Suzuki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c0f92fdeb04e40e1b15ece720d30b9ed
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c0f92fdeb04e40e1b15ece720d30b9ed
record_format	dspace
spelling	oai:doaj.org-article:c0f92fdeb04e40e1b15ece720d30b9ed2021-12-02T15:45:16ZDiagnostic performance and characteristics of anterior nasal collection for the SARS-CoV-2 antigen test: a prospective study10.1038/s41598-021-90026-82045-2322https://doaj.org/article/c0f92fdeb04e40e1b15ece720d30b9ed2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90026-8https://doaj.org/toc/2045-2322Abstract The clinical utility of antigen test using anterior nasal samples has not been well evaluated. We conducted a prospective study in a drive-through testing site located at a PCR center to evaluate the diagnostic performance of the antigen test QuickNavi-COVID19 Ag using anterior nasal samples and to compare the degrees of coughs or sneezes induction and the severity of pain between anterior nasal collection and nasopharyngeal collection. The study included a total of 862 participants, of which 91.6% were symptomatic. The median duration from symptom onset to sample collection was 2.0 days. Fifty-one participants tested positive for severe acute respiratory syndrome coronavirus 2 on reverse transcription PCR (RT-PCR) with nasopharyngeal samples, and all of them were symptomatic. In comparison to the findings of RT-PCR, the antigen test using anterior nasal samples showed 72.5% sensitivity (95% confidence interval [CI] 58.3–84.1%) and 100% specificity (95% CI 99.3–100%). Anterior nasal collection was associated with a significantly lower degree of coughs or sneezes induction and the severity of pain in comparison to nasopharyngeal collection (p < 0.001). The antigen test using anterior nasal samples showed moderate sensitivity in symptomatic patients who were at the early stages of the disease course but was less painful and induced fewer coughs or sneezes.Yuto TakeuchiYusaku AkashiDaisuke KatoMiwa KuwaharaShino MuramatsuAtsuo UedaShigeyuki NotakeKoji NakamuraHiroichi IshikawaHiromichi SuzukiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuto Takeuchi Yusaku Akashi Daisuke Kato Miwa Kuwahara Shino Muramatsu Atsuo Ueda Shigeyuki Notake Koji Nakamura Hiroichi Ishikawa Hiromichi Suzuki Diagnostic performance and characteristics of anterior nasal collection for the SARS-CoV-2 antigen test: a prospective study
description	Abstract The clinical utility of antigen test using anterior nasal samples has not been well evaluated. We conducted a prospective study in a drive-through testing site located at a PCR center to evaluate the diagnostic performance of the antigen test QuickNavi-COVID19 Ag using anterior nasal samples and to compare the degrees of coughs or sneezes induction and the severity of pain between anterior nasal collection and nasopharyngeal collection. The study included a total of 862 participants, of which 91.6% were symptomatic. The median duration from symptom onset to sample collection was 2.0 days. Fifty-one participants tested positive for severe acute respiratory syndrome coronavirus 2 on reverse transcription PCR (RT-PCR) with nasopharyngeal samples, and all of them were symptomatic. In comparison to the findings of RT-PCR, the antigen test using anterior nasal samples showed 72.5% sensitivity (95% confidence interval [CI] 58.3–84.1%) and 100% specificity (95% CI 99.3–100%). Anterior nasal collection was associated with a significantly lower degree of coughs or sneezes induction and the severity of pain in comparison to nasopharyngeal collection (p < 0.001). The antigen test using anterior nasal samples showed moderate sensitivity in symptomatic patients who were at the early stages of the disease course but was less painful and induced fewer coughs or sneezes.
format	article
author	Yuto Takeuchi Yusaku Akashi Daisuke Kato Miwa Kuwahara Shino Muramatsu Atsuo Ueda Shigeyuki Notake Koji Nakamura Hiroichi Ishikawa Hiromichi Suzuki
author_facet	Yuto Takeuchi Yusaku Akashi Daisuke Kato Miwa Kuwahara Shino Muramatsu Atsuo Ueda Shigeyuki Notake Koji Nakamura Hiroichi Ishikawa Hiromichi Suzuki
author_sort	Yuto Takeuchi
title	Diagnostic performance and characteristics of anterior nasal collection for the SARS-CoV-2 antigen test: a prospective study
title_short	Diagnostic performance and characteristics of anterior nasal collection for the SARS-CoV-2 antigen test: a prospective study
title_full	Diagnostic performance and characteristics of anterior nasal collection for the SARS-CoV-2 antigen test: a prospective study
title_fullStr	Diagnostic performance and characteristics of anterior nasal collection for the SARS-CoV-2 antigen test: a prospective study
title_full_unstemmed	Diagnostic performance and characteristics of anterior nasal collection for the SARS-CoV-2 antigen test: a prospective study
title_sort	diagnostic performance and characteristics of anterior nasal collection for the sars-cov-2 antigen test: a prospective study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c0f92fdeb04e40e1b15ece720d30b9ed
work_keys_str_mv	AT yutotakeuchi diagnosticperformanceandcharacteristicsofanteriornasalcollectionforthesarscov2antigentestaprospectivestudy AT yusakuakashi diagnosticperformanceandcharacteristicsofanteriornasalcollectionforthesarscov2antigentestaprospectivestudy AT daisukekato diagnosticperformanceandcharacteristicsofanteriornasalcollectionforthesarscov2antigentestaprospectivestudy AT miwakuwahara diagnosticperformanceandcharacteristicsofanteriornasalcollectionforthesarscov2antigentestaprospectivestudy AT shinomuramatsu diagnosticperformanceandcharacteristicsofanteriornasalcollectionforthesarscov2antigentestaprospectivestudy AT atsuoueda diagnosticperformanceandcharacteristicsofanteriornasalcollectionforthesarscov2antigentestaprospectivestudy AT shigeyukinotake diagnosticperformanceandcharacteristicsofanteriornasalcollectionforthesarscov2antigentestaprospectivestudy AT kojinakamura diagnosticperformanceandcharacteristicsofanteriornasalcollectionforthesarscov2antigentestaprospectivestudy AT hiroichiishikawa diagnosticperformanceandcharacteristicsofanteriornasalcollectionforthesarscov2antigentestaprospectivestudy AT hiromichisuzuki diagnosticperformanceandcharacteristicsofanteriornasalcollectionforthesarscov2antigentestaprospectivestudy
_version_	1718385775622488064

Diagnostic performance and characteristics of anterior nasal collection for the SARS-CoV-2 antigen test: a prospective study

Ejemplares similares