Association of Plasma Branched-Chain and Aromatic Amino Acids with Reduction in Kidney Function Evaluated in Apparently Healthy Adults

The published literature on the association of circulatory branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) with reduced kidney function is inconsistent or conflicting. Clarification of it might help to better understand the underlying pathophysiology and to determine potential bio...

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Autores principales:	MH Mahbub, Natsu Yamaguchi, Yuki Nakagami, Ryosuke Hase, Hidekazu Takahashi, Yasutaka Ishimaru, Rie Watanabe, Hiroyuki Saito, Junki Shimokawa, Hiroshi Yamamoto, Shinya Kikuchi, Tsuyoshi Tanabe
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	plasma amino acids branched-chain aromatic glomerular filtration rate kidney function decline Medicine R
Acceso en línea:	https://doaj.org/article/c0f985b29e9f4c83903e629a0f018142
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spelling	oai:doaj.org-article:c0f985b29e9f4c83903e629a0f0181422021-11-25T18:00:44ZAssociation of Plasma Branched-Chain and Aromatic Amino Acids with Reduction in Kidney Function Evaluated in Apparently Healthy Adults10.3390/jcm102252342077-0383https://doaj.org/article/c0f985b29e9f4c83903e629a0f0181422021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5234https://doaj.org/toc/2077-0383The published literature on the association of circulatory branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) with reduced kidney function is inconsistent or conflicting. Clarification of it might help to better understand the underlying pathophysiology and to determine potential biomarkers for early detection and evaluation of kidney function decline. Our main purpose was to explore and clarify the potential relationships of individual BCAAs and AAAs with estimated glomerular filtration rate (eGFR) decline. We included the data from 2804 healthy subjects and categorized them into three groups based on eGFR tertiles. The associations between individual amino acids and eGFR were explored by covariate-adjusted logistic regression models. There was a progressive increase in the concentrations of BCAAs and AAAs from the upper to the lower tertiles. We revealed significant positive associations of isoleucine, leucine, and phenylalanine with lower tertiles of eGFR in the adjusted models (<i>p</i> < 0.01–0.001). The findings hold a promising potential of using plasma isoleucine, leucine, and phenylalanine levels for evaluation of kidney function decline. Future longitudinal studies should investigate the causal association between altered levels of these amino acids and impaired kidney function and also the utility of the former as potential biomarkers for evaluating the risk and early detection of the latter.MH MahbubNatsu YamaguchiYuki NakagamiRyosuke HaseHidekazu TakahashiYasutaka IshimaruRie WatanabeHiroyuki SaitoJunki ShimokawaHiroshi YamamotoShinya KikuchiTsuyoshi TanabeMDPI AGarticleplasma amino acidsbranched-chainaromaticglomerular filtration ratekidney function declineMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5234, p 5234 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	plasma amino acids branched-chain aromatic glomerular filtration rate kidney function decline Medicine R
spellingShingle	plasma amino acids branched-chain aromatic glomerular filtration rate kidney function decline Medicine R MH Mahbub Natsu Yamaguchi Yuki Nakagami Ryosuke Hase Hidekazu Takahashi Yasutaka Ishimaru Rie Watanabe Hiroyuki Saito Junki Shimokawa Hiroshi Yamamoto Shinya Kikuchi Tsuyoshi Tanabe Association of Plasma Branched-Chain and Aromatic Amino Acids with Reduction in Kidney Function Evaluated in Apparently Healthy Adults
description	The published literature on the association of circulatory branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) with reduced kidney function is inconsistent or conflicting. Clarification of it might help to better understand the underlying pathophysiology and to determine potential biomarkers for early detection and evaluation of kidney function decline. Our main purpose was to explore and clarify the potential relationships of individual BCAAs and AAAs with estimated glomerular filtration rate (eGFR) decline. We included the data from 2804 healthy subjects and categorized them into three groups based on eGFR tertiles. The associations between individual amino acids and eGFR were explored by covariate-adjusted logistic regression models. There was a progressive increase in the concentrations of BCAAs and AAAs from the upper to the lower tertiles. We revealed significant positive associations of isoleucine, leucine, and phenylalanine with lower tertiles of eGFR in the adjusted models (<i>p</i> < 0.01–0.001). The findings hold a promising potential of using plasma isoleucine, leucine, and phenylalanine levels for evaluation of kidney function decline. Future longitudinal studies should investigate the causal association between altered levels of these amino acids and impaired kidney function and also the utility of the former as potential biomarkers for evaluating the risk and early detection of the latter.
format	article
author	MH Mahbub Natsu Yamaguchi Yuki Nakagami Ryosuke Hase Hidekazu Takahashi Yasutaka Ishimaru Rie Watanabe Hiroyuki Saito Junki Shimokawa Hiroshi Yamamoto Shinya Kikuchi Tsuyoshi Tanabe
author_facet	MH Mahbub Natsu Yamaguchi Yuki Nakagami Ryosuke Hase Hidekazu Takahashi Yasutaka Ishimaru Rie Watanabe Hiroyuki Saito Junki Shimokawa Hiroshi Yamamoto Shinya Kikuchi Tsuyoshi Tanabe
author_sort	MH Mahbub
title	Association of Plasma Branched-Chain and Aromatic Amino Acids with Reduction in Kidney Function Evaluated in Apparently Healthy Adults
title_short	Association of Plasma Branched-Chain and Aromatic Amino Acids with Reduction in Kidney Function Evaluated in Apparently Healthy Adults
title_full	Association of Plasma Branched-Chain and Aromatic Amino Acids with Reduction in Kidney Function Evaluated in Apparently Healthy Adults
title_fullStr	Association of Plasma Branched-Chain and Aromatic Amino Acids with Reduction in Kidney Function Evaluated in Apparently Healthy Adults
title_full_unstemmed	Association of Plasma Branched-Chain and Aromatic Amino Acids with Reduction in Kidney Function Evaluated in Apparently Healthy Adults
title_sort	association of plasma branched-chain and aromatic amino acids with reduction in kidney function evaluated in apparently healthy adults
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c0f985b29e9f4c83903e629a0f018142
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Association of Plasma Branched-Chain and Aromatic Amino Acids with Reduction in Kidney Function Evaluated in Apparently Healthy Adults

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