Checks and Balances in Bacterial Cell Division

ABSTRACT Assembly of the division machinery in Gram-negative and Gram-positive bacteria occurs in two time-dependent steps. First, the FtsZ proto-ring localizes at midcell including some FtsN molecules. Subsequently, the proteins that catalyze and regulate septal peptidoglycan (PG) synthesis are rec...

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Autores principales:	Tanneke den Blaauwen, Joen Luirink
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	Escherichia coli cell division divisome peptidoglycan Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/c0f9c31e28a5492bad698cc2cd6a91ff
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spelling	oai:doaj.org-article:c0f9c31e28a5492bad698cc2cd6a91ff2021-11-15T15:55:14ZChecks and Balances in Bacterial Cell Division10.1128/mBio.00149-192150-7511https://doaj.org/article/c0f9c31e28a5492bad698cc2cd6a91ff2019-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00149-19https://doaj.org/toc/2150-7511ABSTRACT Assembly of the division machinery in Gram-negative and Gram-positive bacteria occurs in two time-dependent steps. First, the FtsZ proto-ring localizes at midcell including some FtsN molecules. Subsequently, the proteins that catalyze and regulate septal peptidoglycan (PG) synthesis are recruited including among others, the FtsBLQ-PB1B-FtsW-PBP3 complex. Further accumulation of FtsN finally allows initiation of cell division. It was known that FtsA and FtsQLB somehow prevented this initiation. Recently, A. Boes, S. Olatunji, E. Breukink, and M. Terrak (mBio 10:e01912-18, 2019, https://doi.org/10.1128/mBio.01912-18) reported that this is caused by inhibition of the activity of the PG synthases by FtsBLQ, which has to be outcompeted by accumulation of the PBP1b activating FtsN. This supports a central structural as well as regulatory role for the FtsBLQ protein complex that is conserved only in prokaryotes, making it an attractive target for antibiotic development.Tanneke den BlaauwenJoen LuirinkAmerican Society for MicrobiologyarticleEscherichia colicell divisiondivisomepeptidoglycanMicrobiologyQR1-502ENmBio, Vol 10, Iss 1 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Escherichia coli cell division divisome peptidoglycan Microbiology QR1-502
spellingShingle	Escherichia coli cell division divisome peptidoglycan Microbiology QR1-502 Tanneke den Blaauwen Joen Luirink Checks and Balances in Bacterial Cell Division
description	ABSTRACT Assembly of the division machinery in Gram-negative and Gram-positive bacteria occurs in two time-dependent steps. First, the FtsZ proto-ring localizes at midcell including some FtsN molecules. Subsequently, the proteins that catalyze and regulate septal peptidoglycan (PG) synthesis are recruited including among others, the FtsBLQ-PB1B-FtsW-PBP3 complex. Further accumulation of FtsN finally allows initiation of cell division. It was known that FtsA and FtsQLB somehow prevented this initiation. Recently, A. Boes, S. Olatunji, E. Breukink, and M. Terrak (mBio 10:e01912-18, 2019, https://doi.org/10.1128/mBio.01912-18) reported that this is caused by inhibition of the activity of the PG synthases by FtsBLQ, which has to be outcompeted by accumulation of the PBP1b activating FtsN. This supports a central structural as well as regulatory role for the FtsBLQ protein complex that is conserved only in prokaryotes, making it an attractive target for antibiotic development.
format	article
author	Tanneke den Blaauwen Joen Luirink
author_facet	Tanneke den Blaauwen Joen Luirink
author_sort	Tanneke den Blaauwen
title	Checks and Balances in Bacterial Cell Division
title_short	Checks and Balances in Bacterial Cell Division
title_full	Checks and Balances in Bacterial Cell Division
title_fullStr	Checks and Balances in Bacterial Cell Division
title_full_unstemmed	Checks and Balances in Bacterial Cell Division
title_sort	checks and balances in bacterial cell division
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/c0f9c31e28a5492bad698cc2cd6a91ff
work_keys_str_mv	AT tannekedenblaauwen checksandbalancesinbacterialcelldivision AT joenluirink checksandbalancesinbacterialcelldivision
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Checks and Balances in Bacterial Cell Division

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