Interrogation of the microenvironmental landscape in spinal ependymomas reveals dual functions of tumor-associated macrophages

The intratumoural heterogeneity of spinal ependymomas and the role of microglia in tumour progression remain underexplored. Here, the authors perform single-cell RNA- and ATAC-sequencing data analysis of three subtypes and reveal tumour-associated macrophage subsets with distinct functional phenotyp...

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Autores principales:	Qianqian Zhang, Sijin Cheng, Yongzhi Wang, Mengdi Wang, Yufeng Lu, Zengqi Wen, Yuxin Ge, Qiang Ma, Youqiao Chen, Yaowu Zhang, Ren Cao, Min Li, Weihao Liu, Bo Wang, Qian Wu, Wenqing Jia, Xiaoqun Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c0f9cc2133304699896c132cac49c2ab
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spelling	oai:doaj.org-article:c0f9cc2133304699896c132cac49c2ab2021-11-28T12:34:43ZInterrogation of the microenvironmental landscape in spinal ependymomas reveals dual functions of tumor-associated macrophages10.1038/s41467-021-27018-92041-1723https://doaj.org/article/c0f9cc2133304699896c132cac49c2ab2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27018-9https://doaj.org/toc/2041-1723The intratumoural heterogeneity of spinal ependymomas and the role of microglia in tumour progression remain underexplored. Here, the authors perform single-cell RNA- and ATAC-sequencing data analysis of three subtypes and reveal tumour-associated macrophage subsets with distinct functional phenotypes.Qianqian ZhangSijin ChengYongzhi WangMengdi WangYufeng LuZengqi WenYuxin GeQiang MaYouqiao ChenYaowu ZhangRen CaoMin LiWeihao LiuBo WangQian WuWenqing JiaXiaoqun WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qianqian Zhang Sijin Cheng Yongzhi Wang Mengdi Wang Yufeng Lu Zengqi Wen Yuxin Ge Qiang Ma Youqiao Chen Yaowu Zhang Ren Cao Min Li Weihao Liu Bo Wang Qian Wu Wenqing Jia Xiaoqun Wang Interrogation of the microenvironmental landscape in spinal ependymomas reveals dual functions of tumor-associated macrophages
description	The intratumoural heterogeneity of spinal ependymomas and the role of microglia in tumour progression remain underexplored. Here, the authors perform single-cell RNA- and ATAC-sequencing data analysis of three subtypes and reveal tumour-associated macrophage subsets with distinct functional phenotypes.
format	article
author	Qianqian Zhang Sijin Cheng Yongzhi Wang Mengdi Wang Yufeng Lu Zengqi Wen Yuxin Ge Qiang Ma Youqiao Chen Yaowu Zhang Ren Cao Min Li Weihao Liu Bo Wang Qian Wu Wenqing Jia Xiaoqun Wang
author_facet	Qianqian Zhang Sijin Cheng Yongzhi Wang Mengdi Wang Yufeng Lu Zengqi Wen Yuxin Ge Qiang Ma Youqiao Chen Yaowu Zhang Ren Cao Min Li Weihao Liu Bo Wang Qian Wu Wenqing Jia Xiaoqun Wang
author_sort	Qianqian Zhang
title	Interrogation of the microenvironmental landscape in spinal ependymomas reveals dual functions of tumor-associated macrophages
title_short	Interrogation of the microenvironmental landscape in spinal ependymomas reveals dual functions of tumor-associated macrophages
title_full	Interrogation of the microenvironmental landscape in spinal ependymomas reveals dual functions of tumor-associated macrophages
title_fullStr	Interrogation of the microenvironmental landscape in spinal ependymomas reveals dual functions of tumor-associated macrophages
title_full_unstemmed	Interrogation of the microenvironmental landscape in spinal ependymomas reveals dual functions of tumor-associated macrophages
title_sort	interrogation of the microenvironmental landscape in spinal ependymomas reveals dual functions of tumor-associated macrophages
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c0f9cc2133304699896c132cac49c2ab
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Interrogation of the microenvironmental landscape in spinal ependymomas reveals dual functions of tumor-associated macrophages

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