Electroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates ΔFosB and GluR2 expression

Abstract Acupuncture has been used for treating drug addiction since the 1970s, but little is known about the mechanisms by which acupuncture affects drug cue-induced relapse. The transcription factor delta-FosB (ΔFosB) plays a critical role in behavior and pathology after chronic use of cocaine. ΔF...

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Autores principales:	Ai T. M. Nguyen, Tran V. B. Quach, Peddanna Kotha, Szu-Yu Chien, Iona J. MacDonald, Hsien-Yuan Lane, Cheng-Hao Tu, Jaung-Geng Lin, Yi-Hung Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c0f9cf71485a469ca4fb675e227d1e34
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spelling	oai:doaj.org-article:c0f9cf71485a469ca4fb675e227d1e342021-12-02T16:31:58ZElectroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates ΔFosB and GluR2 expression10.1038/s41598-021-93014-02045-2322https://doaj.org/article/c0f9cf71485a469ca4fb675e227d1e342021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93014-0https://doaj.org/toc/2045-2322Abstract Acupuncture has been used for treating drug addiction since the 1970s, but little is known about the mechanisms by which acupuncture affects drug cue-induced relapse. The transcription factor delta-FosB (ΔFosB) plays a critical role in behavior and pathology after chronic use of cocaine. ΔFosB regulates glutamate receptor signaling and dendritic spine morphology in animal models. This experimental study compared the effects of electroacupuncture (EA) at acupoints LI4 and LI11 with those of another potentially beneficial intervention, gabapentin (GBP), alone or in combination, on reinstatement of cocaine-induced conditioned place preference (CPP) and levels of ΔFosB and glutamate receptor subunit 2 (GluR2) expression in the nucleus accumbens (NAc). EA at LI4 and LI11 significantly prevented cue-induced cocaine CPP reinstatement, whereas needle insertion without electrical stimulation at these acupoints had no such effect. EA also significantly attenuated cocaine-induced increases in ΔFosB and GluR2 expression in the NAc. Unexpectedly, these effects were reversed when GBP was combined with EA. Treatment with EA at LI4 and LI11 prevented cocaine-induced increases in dendritic spine density in the NAc core and shell. Our results suggest that EA at LI4 and LI11 may prevent cocaine relapse by modulating ΔFosB and GluR2 expression, as well as dendritic spine density.Ai T. M. NguyenTran V. B. QuachPeddanna KothaSzu-Yu ChienIona J. MacDonaldHsien-Yuan LaneCheng-Hao TuJaung-Geng LinYi-Hung ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ai T. M. Nguyen Tran V. B. Quach Peddanna Kotha Szu-Yu Chien Iona J. MacDonald Hsien-Yuan Lane Cheng-Hao Tu Jaung-Geng Lin Yi-Hung Chen Electroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates ΔFosB and GluR2 expression
description	Abstract Acupuncture has been used for treating drug addiction since the 1970s, but little is known about the mechanisms by which acupuncture affects drug cue-induced relapse. The transcription factor delta-FosB (ΔFosB) plays a critical role in behavior and pathology after chronic use of cocaine. ΔFosB regulates glutamate receptor signaling and dendritic spine morphology in animal models. This experimental study compared the effects of electroacupuncture (EA) at acupoints LI4 and LI11 with those of another potentially beneficial intervention, gabapentin (GBP), alone or in combination, on reinstatement of cocaine-induced conditioned place preference (CPP) and levels of ΔFosB and glutamate receptor subunit 2 (GluR2) expression in the nucleus accumbens (NAc). EA at LI4 and LI11 significantly prevented cue-induced cocaine CPP reinstatement, whereas needle insertion without electrical stimulation at these acupoints had no such effect. EA also significantly attenuated cocaine-induced increases in ΔFosB and GluR2 expression in the NAc. Unexpectedly, these effects were reversed when GBP was combined with EA. Treatment with EA at LI4 and LI11 prevented cocaine-induced increases in dendritic spine density in the NAc core and shell. Our results suggest that EA at LI4 and LI11 may prevent cocaine relapse by modulating ΔFosB and GluR2 expression, as well as dendritic spine density.
format	article
author	Ai T. M. Nguyen Tran V. B. Quach Peddanna Kotha Szu-Yu Chien Iona J. MacDonald Hsien-Yuan Lane Cheng-Hao Tu Jaung-Geng Lin Yi-Hung Chen
author_facet	Ai T. M. Nguyen Tran V. B. Quach Peddanna Kotha Szu-Yu Chien Iona J. MacDonald Hsien-Yuan Lane Cheng-Hao Tu Jaung-Geng Lin Yi-Hung Chen
author_sort	Ai T. M. Nguyen
title	Electroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates ΔFosB and GluR2 expression
title_short	Electroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates ΔFosB and GluR2 expression
title_full	Electroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates ΔFosB and GluR2 expression
title_fullStr	Electroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates ΔFosB and GluR2 expression
title_full_unstemmed	Electroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates ΔFosB and GluR2 expression
title_sort	electroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates δfosb and glur2 expression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c0f9cf71485a469ca4fb675e227d1e34
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Electroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates ΔFosB and GluR2 expression

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