All roads lead to Rome — a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer’s disease
Age-related neurodegenerative disorders such as Alzheimer’s disease (AD) have become a critical public health issue due to the significantly extended human lifespan, leading to considerable economic and social burdens. Traditional therapies for AD such as medicine and surgery remain ineffective, imp...
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Wolters Kluwer Medknow Publications
2022
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oai:doaj.org-article:c1072072f48849a491185624e98639ba2021-11-19T12:16:44ZAll roads lead to Rome — a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer’s disease1673-537410.4103/1673-5374.325012https://doaj.org/article/c1072072f48849a491185624e98639ba2022-01-01T00:00:00Zhttp://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=6;spage=1210;epage=1227;aulast=Lianghttps://doaj.org/toc/1673-5374Age-related neurodegenerative disorders such as Alzheimer’s disease (AD) have become a critical public health issue due to the significantly extended human lifespan, leading to considerable economic and social burdens. Traditional therapies for AD such as medicine and surgery remain ineffective, impractical, and expensive. Many studies have shown that a variety of bioactive substances released by physical exercise (called “exerkines”) help to maintain and improve the normal functions of the brain in terms of cognition, emotion, and psychomotor coordination. Increasing evidence suggests that exerkines may exert beneficial effects in AD as well. This review summarizes the neuroprotective effects of exerkines in AD, focusing on the underlying molecular mechanism and the dynamic expression of exerkines after physical exercise. The findings described in this review will help direct research into novel targets for the treatment of AD and develop customized exercise therapy for individuals of different ages, genders, and health conditions.Yi-Yao LiangLi-Dan ZhangXi LuoLi-Li WuZhao-Wei ChenGuang-Hao WeiKai-Qing ZhangZe-An DuRen-Zhi LiKwok-Fai SoAng LiWolters Kluwer Medknow Publicationsarticlealzheimer′s disease; amyloid beta; central nervous system; exerkine; neurodegeneration; neuroinflammation; neuroprotection; oxidative stress; physical exercise; tau proteinNeurology. Diseases of the nervous systemRC346-429ENNeural Regeneration Research, Vol 17, Iss 6, Pp 1210-1227 (2022) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
alzheimer′s disease; amyloid beta; central nervous system; exerkine; neurodegeneration; neuroinflammation; neuroprotection; oxidative stress; physical exercise; tau protein Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
alzheimer′s disease; amyloid beta; central nervous system; exerkine; neurodegeneration; neuroinflammation; neuroprotection; oxidative stress; physical exercise; tau protein Neurology. Diseases of the nervous system RC346-429 Yi-Yao Liang Li-Dan Zhang Xi Luo Li-Li Wu Zhao-Wei Chen Guang-Hao Wei Kai-Qing Zhang Ze-An Du Ren-Zhi Li Kwok-Fai So Ang Li All roads lead to Rome — a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer’s disease |
| description |
Age-related neurodegenerative disorders such as Alzheimer’s disease (AD) have become a critical public health issue due to the significantly extended human lifespan, leading to considerable economic and social burdens. Traditional therapies for AD such as medicine and surgery remain ineffective, impractical, and expensive. Many studies have shown that a variety of bioactive substances released by physical exercise (called “exerkines”) help to maintain and improve the normal functions of the brain in terms of cognition, emotion, and psychomotor coordination. Increasing evidence suggests that exerkines may exert beneficial effects in AD as well. This review summarizes the neuroprotective effects of exerkines in AD, focusing on the underlying molecular mechanism and the dynamic expression of exerkines after physical exercise. The findings described in this review will help direct research into novel targets for the treatment of AD and develop customized exercise therapy for individuals of different ages, genders, and health conditions. |
| format |
article |
| author |
Yi-Yao Liang Li-Dan Zhang Xi Luo Li-Li Wu Zhao-Wei Chen Guang-Hao Wei Kai-Qing Zhang Ze-An Du Ren-Zhi Li Kwok-Fai So Ang Li |
| author_facet |
Yi-Yao Liang Li-Dan Zhang Xi Luo Li-Li Wu Zhao-Wei Chen Guang-Hao Wei Kai-Qing Zhang Ze-An Du Ren-Zhi Li Kwok-Fai So Ang Li |
| author_sort |
Yi-Yao Liang |
| title |
All roads lead to Rome — a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer’s disease |
| title_short |
All roads lead to Rome — a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer’s disease |
| title_full |
All roads lead to Rome — a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer’s disease |
| title_fullStr |
All roads lead to Rome — a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer’s disease |
| title_full_unstemmed |
All roads lead to Rome — a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer’s disease |
| title_sort |
all roads lead to rome — a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in alzheimer’s disease |
| publisher |
Wolters Kluwer Medknow Publications |
| publishDate |
2022 |
| url |
https://doaj.org/article/c1072072f48849a491185624e98639ba |
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