Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity

Mito-SEPs are small peptides that can modulate oxidative metabolism in mitochondria. Here the authors show that C15ORF48 encodes a mito-SEP, MOCCI, capable of altering mitochondria respiration to suppress inflammation, while C15ORF48 3’ untranslated region also contains a miRNA, miR-147b, that syner...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cheryl Q. E. Lee, Baptiste Kerouanton, Sonia Chothani, Shan Zhang, Ying Chen, Chinmay Kumar Mantri, Daniella Helena Hock, Radiance Lim, Rhea Nadkarni, Vinh Thang Huynh, Daryl Lim, Wei Leong Chew, Franklin L. Zhong, David Arthur Stroud, Sebastian Schafer, Vinay Tergaonkar, Ashley L. St John, Owen J. L. Rackham, Lena Ho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c10b340027cd468680f3b74537ae38a8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c10b340027cd468680f3b74537ae38a8
record_format	dspace
spelling	oai:doaj.org-article:c10b340027cd468680f3b74537ae38a82021-12-02T14:37:27ZCoding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity10.1038/s41467-021-22397-52041-1723https://doaj.org/article/c10b340027cd468680f3b74537ae38a82021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22397-5https://doaj.org/toc/2041-1723Mito-SEPs are small peptides that can modulate oxidative metabolism in mitochondria. Here the authors show that C15ORF48 encodes a mito-SEP, MOCCI, capable of altering mitochondria respiration to suppress inflammation, while C15ORF48 3’ untranslated region also contains a miRNA, miR-147b, that synergizes with MOCCI to modulate host anti-viral responses.Cheryl Q. E. LeeBaptiste KerouantonSonia ChothaniShan ZhangYing ChenChinmay Kumar MantriDaniella Helena HockRadiance LimRhea NadkarniVinh Thang HuynhDaryl LimWei Leong ChewFranklin L. ZhongDavid Arthur StroudSebastian SchaferVinay TergaonkarAshley L. St JohnOwen J. L. RackhamLena HoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cheryl Q. E. Lee Baptiste Kerouanton Sonia Chothani Shan Zhang Ying Chen Chinmay Kumar Mantri Daniella Helena Hock Radiance Lim Rhea Nadkarni Vinh Thang Huynh Daryl Lim Wei Leong Chew Franklin L. Zhong David Arthur Stroud Sebastian Schafer Vinay Tergaonkar Ashley L. St John Owen J. L. Rackham Lena Ho Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity
description	Mito-SEPs are small peptides that can modulate oxidative metabolism in mitochondria. Here the authors show that C15ORF48 encodes a mito-SEP, MOCCI, capable of altering mitochondria respiration to suppress inflammation, while C15ORF48 3’ untranslated region also contains a miRNA, miR-147b, that synergizes with MOCCI to modulate host anti-viral responses.
format	article
author	Cheryl Q. E. Lee Baptiste Kerouanton Sonia Chothani Shan Zhang Ying Chen Chinmay Kumar Mantri Daniella Helena Hock Radiance Lim Rhea Nadkarni Vinh Thang Huynh Daryl Lim Wei Leong Chew Franklin L. Zhong David Arthur Stroud Sebastian Schafer Vinay Tergaonkar Ashley L. St John Owen J. L. Rackham Lena Ho
author_facet	Cheryl Q. E. Lee Baptiste Kerouanton Sonia Chothani Shan Zhang Ying Chen Chinmay Kumar Mantri Daniella Helena Hock Radiance Lim Rhea Nadkarni Vinh Thang Huynh Daryl Lim Wei Leong Chew Franklin L. Zhong David Arthur Stroud Sebastian Schafer Vinay Tergaonkar Ashley L. St John Owen J. L. Rackham Lena Ho
author_sort	Cheryl Q. E. Lee
title	Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity
title_short	Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity
title_full	Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity
title_fullStr	Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity
title_full_unstemmed	Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity
title_sort	coding and non-coding roles of mocci (c15orf48) coordinate to regulate host inflammation and immunity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c10b340027cd468680f3b74537ae38a8
work_keys_str_mv	AT cherylqelee codingandnoncodingrolesofmoccic15orf48coordinatetoregulatehostinflammationandimmunity AT baptistekerouanton codingandnoncodingrolesofmoccic15orf48coordinatetoregulatehostinflammationandimmunity AT soniachothani codingandnoncodingrolesofmoccic15orf48coordinatetoregulatehostinflammationandimmunity AT shanzhang codingandnoncodingrolesofmoccic15orf48coordinatetoregulatehostinflammationandimmunity AT yingchen codingandnoncodingrolesofmoccic15orf48coordinatetoregulatehostinflammationandimmunity AT chinmaykumarmantri codingandnoncodingrolesofmoccic15orf48coordinatetoregulatehostinflammationandimmunity AT daniellahelenahock codingandnoncodingrolesofmoccic15orf48coordinatetoregulatehostinflammationandimmunity AT radiancelim codingandnoncodingrolesofmoccic15orf48coordinatetoregulatehostinflammationandimmunity AT rheanadkarni codingandnoncodingrolesofmoccic15orf48coordinatetoregulatehostinflammationandimmunity AT vinhthanghuynh codingandnoncodingrolesofmoccic15orf48coordinatetoregulatehostinflammationandimmunity AT daryllim codingandnoncodingrolesofmoccic15orf48coordinatetoregulatehostinflammationandimmunity AT weileongchew codingandnoncodingrolesofmoccic15orf48coordinatetoregulatehostinflammationandimmunity AT franklinlzhong codingandnoncodingrolesofmoccic15orf48coordinatetoregulatehostinflammationandimmunity AT davidarthurstroud codingandnoncodingrolesofmoccic15orf48coordinatetoregulatehostinflammationandimmunity AT sebastianschafer codingandnoncodingrolesofmoccic15orf48coordinatetoregulatehostinflammationandimmunity AT vinaytergaonkar codingandnoncodingrolesofmoccic15orf48coordinatetoregulatehostinflammationandimmunity AT ashleylstjohn codingandnoncodingrolesofmoccic15orf48coordinatetoregulatehostinflammationandimmunity AT owenjlrackham codingandnoncodingrolesofmoccic15orf48coordinatetoregulatehostinflammationandimmunity AT lenaho codingandnoncodingrolesofmoccic15orf48coordinatetoregulatehostinflammationandimmunity
_version_	1718391032571232256

Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity

Ejemplares similares