Neural correlates of emotional processing in panic disorder

Background: Deficits in emotional processing are conceptualized in prevailing models of anxiety to underpin key symptoms of panic disorder (PD). Neuroimaging studies show evidence of aberrant neural functioning in PD patients during emotional processing, however little is understood about how non-co...

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Autores principales:	Mayuresh S. Korgaonkar, Jenny Tran, Kim L. Felmingham, Leanne M. Williams, Richard A. Bryant
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Panic disorder Emotion processing fMRI Subliminal Supraliminal Connectivity Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/c10bfb522a1540cf94e2c0b3df57a65a
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spelling	oai:doaj.org-article:c10bfb522a1540cf94e2c0b3df57a65a2021-12-04T04:34:02ZNeural correlates of emotional processing in panic disorder2213-158210.1016/j.nicl.2021.102902https://doaj.org/article/c10bfb522a1540cf94e2c0b3df57a65a2021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213158221003466https://doaj.org/toc/2213-1582Background: Deficits in emotional processing are conceptualized in prevailing models of anxiety to underpin key symptoms of panic disorder (PD). Neuroimaging studies show evidence of aberrant neural functioning in PD patients during emotional processing, however little is understood about how non-conscious emotional processing impacts neural processes. Method: We examined activation and functional connectivity differences in brain regions involved in emotional processing between PD and healthy controls (HC) during subliminal and supraliminal presentations of facial emotions. Twenty-two PD and 33 HC participants were shown happy, sad, neutral, fear, anger and disgust facial expressions during functional magnetic resonance imaging using a 3T MRI scanner. We performed voxelwise ROI analyses at FWE-corrected p < 0.05 for main effects of group and groupemotion interactions. Results: There was less pregenual anterior cingulate cortex (pgACC) activation to subliminal presentations of happy and sad faces in PD compared to HC participants (groupemotion). In addition, PD patients had less pgACC - right amygdala connectivity than HC participants during sad and fear subliminal processing (group*emotion). PD patients also exhibited lower right cerebellum activity across all supraliminal presentations of facial expressions compared to HC. Conclusion: These findings suggest that there is aberrant neural processing in PD patients during both conscious and preconscious processing of both positive and negative stimuli, suggesting impaired recruitment of implicit regulatory networks during affective processing. It appears that PD patients may experience deficits in key regulatory connections between inhibitory and emotional neural networks at very early stages of processing of negative affective states.Mayuresh S. KorgaonkarJenny TranKim L. FelminghamLeanne M. WilliamsRichard A. BryantElsevierarticlePanic disorderEmotion processingfMRISubliminalSupraliminalConnectivityComputer applications to medicine. Medical informaticsR858-859.7Neurology. Diseases of the nervous systemRC346-429ENNeuroImage: Clinical, Vol 32, Iss , Pp 102902- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Panic disorder Emotion processing fMRI Subliminal Supraliminal Connectivity Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Panic disorder Emotion processing fMRI Subliminal Supraliminal Connectivity Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429 Mayuresh S. Korgaonkar Jenny Tran Kim L. Felmingham Leanne M. Williams Richard A. Bryant Neural correlates of emotional processing in panic disorder
description	Background: Deficits in emotional processing are conceptualized in prevailing models of anxiety to underpin key symptoms of panic disorder (PD). Neuroimaging studies show evidence of aberrant neural functioning in PD patients during emotional processing, however little is understood about how non-conscious emotional processing impacts neural processes. Method: We examined activation and functional connectivity differences in brain regions involved in emotional processing between PD and healthy controls (HC) during subliminal and supraliminal presentations of facial emotions. Twenty-two PD and 33 HC participants were shown happy, sad, neutral, fear, anger and disgust facial expressions during functional magnetic resonance imaging using a 3T MRI scanner. We performed voxelwise ROI analyses at FWE-corrected p < 0.05 for main effects of group and groupemotion interactions. Results: There was less pregenual anterior cingulate cortex (pgACC) activation to subliminal presentations of happy and sad faces in PD compared to HC participants (groupemotion). In addition, PD patients had less pgACC - right amygdala connectivity than HC participants during sad and fear subliminal processing (group*emotion). PD patients also exhibited lower right cerebellum activity across all supraliminal presentations of facial expressions compared to HC. Conclusion: These findings suggest that there is aberrant neural processing in PD patients during both conscious and preconscious processing of both positive and negative stimuli, suggesting impaired recruitment of implicit regulatory networks during affective processing. It appears that PD patients may experience deficits in key regulatory connections between inhibitory and emotional neural networks at very early stages of processing of negative affective states.
format	article
author	Mayuresh S. Korgaonkar Jenny Tran Kim L. Felmingham Leanne M. Williams Richard A. Bryant
author_facet	Mayuresh S. Korgaonkar Jenny Tran Kim L. Felmingham Leanne M. Williams Richard A. Bryant
author_sort	Mayuresh S. Korgaonkar
title	Neural correlates of emotional processing in panic disorder
title_short	Neural correlates of emotional processing in panic disorder
title_full	Neural correlates of emotional processing in panic disorder
title_fullStr	Neural correlates of emotional processing in panic disorder
title_full_unstemmed	Neural correlates of emotional processing in panic disorder
title_sort	neural correlates of emotional processing in panic disorder
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/c10bfb522a1540cf94e2c0b3df57a65a
work_keys_str_mv	AT mayureshskorgaonkar neuralcorrelatesofemotionalprocessinginpanicdisorder AT jennytran neuralcorrelatesofemotionalprocessinginpanicdisorder AT kimlfelmingham neuralcorrelatesofemotionalprocessinginpanicdisorder AT leannemwilliams neuralcorrelatesofemotionalprocessinginpanicdisorder AT richardabryant neuralcorrelatesofemotionalprocessinginpanicdisorder
_version_	1718372992942080000

Neural correlates of emotional processing in panic disorder

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