Genome-wide analysis of chromosomal import patterns after natural transformation of Helicobacter pylori

Uptake and integration of exogenous DNA into the bacterial genome play an important role in the evolution of the pathogen Helicobacter pylori. Here, the authors describe a bimodal pattern of chromosomal integration and show how restriction-modification systems limit the import of heterologous DNA.

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Detalles Bibliográficos
Autores principales: Sebastian Bubendorfer, Juliane Krebes, Ines Yang, Elias Hage, Thomas F. Schulz, Christelle Bahlawane, Xavier Didelot, Sebastian Suerbaum
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/c10cff1771e842f087f6299edbe521bd
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Sumario:Uptake and integration of exogenous DNA into the bacterial genome play an important role in the evolution of the pathogen Helicobacter pylori. Here, the authors describe a bimodal pattern of chromosomal integration and show how restriction-modification systems limit the import of heterologous DNA.