Suppression of top-down influence decreases neuronal excitability and contrast sensitivity in the V1 cortex of cat

Abstract How top-down influence affects neuronal activity and information encoding in the primary visual cortex (V1) remains elusive. This study examined changes of neuronal excitability and contrast sensitivity in cat V1 cortex after top-down influence of area 7 (A7) was modulated by transcranial d...

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Autores principales:	Jian Ding, Xiangmei Hu, Fei Xu, Hao Yu, Zheng Ye, Shen Zhang, Huijun Pan, Deng Pan, Yanni Tu, Qiuyu Zhang, Qingyan Sun, Tianmiao Hua
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c11447aee12140a9bc8c692281082d63
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spelling	oai:doaj.org-article:c11447aee12140a9bc8c692281082d632021-12-02T18:49:30ZSuppression of top-down influence decreases neuronal excitability and contrast sensitivity in the V1 cortex of cat10.1038/s41598-021-95407-72045-2322https://doaj.org/article/c11447aee12140a9bc8c692281082d632021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95407-7https://doaj.org/toc/2045-2322Abstract How top-down influence affects neuronal activity and information encoding in the primary visual cortex (V1) remains elusive. This study examined changes of neuronal excitability and contrast sensitivity in cat V1 cortex after top-down influence of area 7 (A7) was modulated by transcranial direct current stimulation (tDCS). The neuronal excitability in V1 cortex was evaluated by visually evoked field potentials (VEPs), and contrast sensitivity (CS) was assessed by the inverse of threshold contrast of neurons in response to visual stimuli at different performance accuracy. We found that the amplitude of VEPs in V1 cortex lowered after top-down influence suppression with cathode-tDCS in A7, whereas VEPs in V1 did not change after sham-tDCS in A7 and nonvisual cortical area 5 (A5) or cathode-tDCS in A5 and lesioned A7. Moreover, the mean CS of V1 neurons decreased after cathode-tDCS but not sham-tDCS in A7, which could recover after tDCS effect vanished. Comparisons of neuronal contrast-response functions showed that cathode-tDCS increased the stimulus contrast required to generate the half-maximum response, with a weakly-correlated reduction in maximum response but not baseline response. Therefore, top-down influence of A7 enhanced neuronal excitability in V1 cortex and improved neuronal contrast sensitivity by both contrast gain and response gain.Jian DingXiangmei HuFei XuHao YuZheng YeShen ZhangHuijun PanDeng PanYanni TuQiuyu ZhangQingyan SunTianmiao HuaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jian Ding Xiangmei Hu Fei Xu Hao Yu Zheng Ye Shen Zhang Huijun Pan Deng Pan Yanni Tu Qiuyu Zhang Qingyan Sun Tianmiao Hua Suppression of top-down influence decreases neuronal excitability and contrast sensitivity in the V1 cortex of cat
description	Abstract How top-down influence affects neuronal activity and information encoding in the primary visual cortex (V1) remains elusive. This study examined changes of neuronal excitability and contrast sensitivity in cat V1 cortex after top-down influence of area 7 (A7) was modulated by transcranial direct current stimulation (tDCS). The neuronal excitability in V1 cortex was evaluated by visually evoked field potentials (VEPs), and contrast sensitivity (CS) was assessed by the inverse of threshold contrast of neurons in response to visual stimuli at different performance accuracy. We found that the amplitude of VEPs in V1 cortex lowered after top-down influence suppression with cathode-tDCS in A7, whereas VEPs in V1 did not change after sham-tDCS in A7 and nonvisual cortical area 5 (A5) or cathode-tDCS in A5 and lesioned A7. Moreover, the mean CS of V1 neurons decreased after cathode-tDCS but not sham-tDCS in A7, which could recover after tDCS effect vanished. Comparisons of neuronal contrast-response functions showed that cathode-tDCS increased the stimulus contrast required to generate the half-maximum response, with a weakly-correlated reduction in maximum response but not baseline response. Therefore, top-down influence of A7 enhanced neuronal excitability in V1 cortex and improved neuronal contrast sensitivity by both contrast gain and response gain.
format	article
author	Jian Ding Xiangmei Hu Fei Xu Hao Yu Zheng Ye Shen Zhang Huijun Pan Deng Pan Yanni Tu Qiuyu Zhang Qingyan Sun Tianmiao Hua
author_facet	Jian Ding Xiangmei Hu Fei Xu Hao Yu Zheng Ye Shen Zhang Huijun Pan Deng Pan Yanni Tu Qiuyu Zhang Qingyan Sun Tianmiao Hua
author_sort	Jian Ding
title	Suppression of top-down influence decreases neuronal excitability and contrast sensitivity in the V1 cortex of cat
title_short	Suppression of top-down influence decreases neuronal excitability and contrast sensitivity in the V1 cortex of cat
title_full	Suppression of top-down influence decreases neuronal excitability and contrast sensitivity in the V1 cortex of cat
title_fullStr	Suppression of top-down influence decreases neuronal excitability and contrast sensitivity in the V1 cortex of cat
title_full_unstemmed	Suppression of top-down influence decreases neuronal excitability and contrast sensitivity in the V1 cortex of cat
title_sort	suppression of top-down influence decreases neuronal excitability and contrast sensitivity in the v1 cortex of cat
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c11447aee12140a9bc8c692281082d63
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Suppression of top-down influence decreases neuronal excitability and contrast sensitivity in the V1 cortex of cat

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