Infrared light-absorbing gold/gold sulfide nanoparticles induce cell death in esophageal adenocarcinoma

Yan Li,1 Andre M Gobin,2 Gerald W Dryden,3 Xinqin Kang,1 Deyi Xiao,1 Su Ping Li,1 Guandong Zhang,2 Robert CG Martin11Department of Surgery, 2Department of Bioengineering, 3Division of Medicine, University of Louisville School of Medicine, Louisville, KY, USAAbstract: Gold nanoparticles and near infr...

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Autores principales:	Li Y, Gobin AM, Dryden GW, Kang X, Xiao D, Li SP, Zhang G, Martin RCG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c1156de1c8b943b184b5f2e6812de070
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spelling	oai:doaj.org-article:c1156de1c8b943b184b5f2e6812de0702021-12-02T02:44:04ZInfrared light-absorbing gold/gold sulfide nanoparticles induce cell death in esophageal adenocarcinoma1176-91141178-2013https://doaj.org/article/c1156de1c8b943b184b5f2e6812de0702013-06-01T00:00:00Zhttp://www.dovepress.com/infrared-light-absorbing-goldgold-sulfide-nanoparticles-induce-cell-de-a13388https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Yan Li,1 Andre M Gobin,2 Gerald W Dryden,3 Xinqin Kang,1 Deyi Xiao,1 Su Ping Li,1 Guandong Zhang,2 Robert CG Martin11Department of Surgery, 2Department of Bioengineering, 3Division of Medicine, University of Louisville School of Medicine, Louisville, KY, USAAbstract: Gold nanoparticles and near infrared-absorbing light are each innocuous to tissue but when combined can destroy malignant tissue while leaving healthy tissue unharmed. This study investigated the feasibility of photothermal ablation therapy for esophageal adenocarcinoma using chitosan-coated gold/gold sulfide (CS-GGS) nanoparticles. A rat esophagoduodenal anastomosis model was used for the in vivo ablation study, and three human esophageal cell lines were used to study the response of cancer cells and benign cells to near infrared light after treatment with CS-GGS. The results indicate that both cancerous tissue and cancer cells took up more gold nanoparticles and were completely ablated after exposure to near infrared light. The benign tissue and noncancerous cells showed less uptake of these nanoparticles, and remained viable after exposure to near infrared light. CS-GGS nanoparticles could provide an optimal endoluminal therapeutic option for near infrared light ablation of esophageal cancer.Keywords: carcinoma, gold nanoparticles, ablation, near infrared, chitosan, drug uptake, cancerLi YGobin AMDryden GWKang XXiao DLi SPZhang GMartin RCGDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 2153-2161 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Li Y Gobin AM Dryden GW Kang X Xiao D Li SP Zhang G Martin RCG Infrared light-absorbing gold/gold sulfide nanoparticles induce cell death in esophageal adenocarcinoma
description	Yan Li,1 Andre M Gobin,2 Gerald W Dryden,3 Xinqin Kang,1 Deyi Xiao,1 Su Ping Li,1 Guandong Zhang,2 Robert CG Martin11Department of Surgery, 2Department of Bioengineering, 3Division of Medicine, University of Louisville School of Medicine, Louisville, KY, USAAbstract: Gold nanoparticles and near infrared-absorbing light are each innocuous to tissue but when combined can destroy malignant tissue while leaving healthy tissue unharmed. This study investigated the feasibility of photothermal ablation therapy for esophageal adenocarcinoma using chitosan-coated gold/gold sulfide (CS-GGS) nanoparticles. A rat esophagoduodenal anastomosis model was used for the in vivo ablation study, and three human esophageal cell lines were used to study the response of cancer cells and benign cells to near infrared light after treatment with CS-GGS. The results indicate that both cancerous tissue and cancer cells took up more gold nanoparticles and were completely ablated after exposure to near infrared light. The benign tissue and noncancerous cells showed less uptake of these nanoparticles, and remained viable after exposure to near infrared light. CS-GGS nanoparticles could provide an optimal endoluminal therapeutic option for near infrared light ablation of esophageal cancer.Keywords: carcinoma, gold nanoparticles, ablation, near infrared, chitosan, drug uptake, cancer
format	article
author	Li Y Gobin AM Dryden GW Kang X Xiao D Li SP Zhang G Martin RCG
author_facet	Li Y Gobin AM Dryden GW Kang X Xiao D Li SP Zhang G Martin RCG
author_sort	Li Y
title	Infrared light-absorbing gold/gold sulfide nanoparticles induce cell death in esophageal adenocarcinoma
title_short	Infrared light-absorbing gold/gold sulfide nanoparticles induce cell death in esophageal adenocarcinoma
title_full	Infrared light-absorbing gold/gold sulfide nanoparticles induce cell death in esophageal adenocarcinoma
title_fullStr	Infrared light-absorbing gold/gold sulfide nanoparticles induce cell death in esophageal adenocarcinoma
title_full_unstemmed	Infrared light-absorbing gold/gold sulfide nanoparticles induce cell death in esophageal adenocarcinoma
title_sort	infrared light-absorbing gold/gold sulfide nanoparticles induce cell death in esophageal adenocarcinoma
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/c1156de1c8b943b184b5f2e6812de070
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Infrared light-absorbing gold/gold sulfide nanoparticles induce cell death in esophageal adenocarcinoma

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