Review of the Application of Nanovesicles and the Human Interstitial Fluid in Gastrointestinal Premalignant Lesion Detection, Diagnosis, Prognosis and Therapy

Yu Huang,1 Xin Deng,2,3 Jian Liang4 1Liuzhou Traditional Chinese Medical Hospital, Liuzhou 545001, Guangxi Zhuang Autonomous Region, People’s Republic of China; 2Guangxi University of Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region, People’s Republic of China;...

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Autores principales:	Huang Y, Deng X, Liang J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	gastrointestinal premalignant lesions nanovesicles human interstitium Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c1163aba451d4015859a9ae9b83a8631
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spelling	oai:doaj.org-article:c1163aba451d4015859a9ae9b83a86312021-12-02T06:20:52ZReview of the Application of Nanovesicles and the Human Interstitial Fluid in Gastrointestinal Premalignant Lesion Detection, Diagnosis, Prognosis and Therapy1178-2013https://doaj.org/article/c1163aba451d4015859a9ae9b83a86312019-12-01T00:00:00Zhttps://www.dovepress.com/review-of-the-application-of-nanovesicles-and-the-human-interstitial-f-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yu Huang,1 Xin Deng,2,3 Jian Liang4 1Liuzhou Traditional Chinese Medical Hospital, Liuzhou 545001, Guangxi Zhuang Autonomous Region, People’s Republic of China; 2Guangxi University of Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region, People’s Republic of China; 3Shanghai Jiao Tong University, Shanghai 200240, People’s Republic of China; 4Guangxi University, Nanning 530004, Guangxi Zhuang Autonomous Region, People’s Republic of ChinaCorrespondence: Xin DengGuangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, 800 Dongchuan Road, Nanning 530001, People’s Republic of ChinaEmail 260446391@qq.comAbstract: Premalignant lesions arise from cells that abnormally proliferate and have a tendency to become cancerous. Developing methods to specifically target and remove these premalignant lesions is imperative to the prevention of malignant progression into gastrointestinal (GI) tumors. However, accurate detection and diagnosis of GI precancerous lesions is challenging, as these lesions show little or no structural change. Thus, this prevents early intervention and reduces the success rate of therapy. In this review, we performed a systematic analysis of the technological advancements in the combined application of nanovesicles (NVs) and the human interstitial fluid (HIF) to specifically target GI premalignant lesions. NVs, which include quantum dots (QDs), are small membranous vehicles of a nanometer diameter that are widely used as drug delivery vectors, therapeutic effectors and diagnostic sensors. HIF is the fluid that is present in human interstitial tissues (HITs) in which signaling molecules and agents travel and can be found throughout the body. HIF is exploited by tumor cells for their invasion, migration and spread. Because the HITs span the entire submucosa of the gastrointestinal tract, they have been increasingly targeted in GI tumor therapy. The challenges involved in the combined application of NVs and HIF in the detection, diagnosis, prognosis and therapy of GI premalignant lesions are also discussed.Keywords: gastrointestinal premalignant lesions, nanovesicles, human interstitiumHuang YDeng XLiang JDove Medical Pressarticlegastrointestinal premalignant lesionsnanovesicleshuman interstitiumMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 9469-9482 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	gastrointestinal premalignant lesions nanovesicles human interstitium Medicine (General) R5-920
spellingShingle	gastrointestinal premalignant lesions nanovesicles human interstitium Medicine (General) R5-920 Huang Y Deng X Liang J Review of the Application of Nanovesicles and the Human Interstitial Fluid in Gastrointestinal Premalignant Lesion Detection, Diagnosis, Prognosis and Therapy
description	Yu Huang,1 Xin Deng,2,3 Jian Liang4 1Liuzhou Traditional Chinese Medical Hospital, Liuzhou 545001, Guangxi Zhuang Autonomous Region, People’s Republic of China; 2Guangxi University of Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region, People’s Republic of China; 3Shanghai Jiao Tong University, Shanghai 200240, People’s Republic of China; 4Guangxi University, Nanning 530004, Guangxi Zhuang Autonomous Region, People’s Republic of ChinaCorrespondence: Xin DengGuangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, 800 Dongchuan Road, Nanning 530001, People’s Republic of ChinaEmail 260446391@qq.comAbstract: Premalignant lesions arise from cells that abnormally proliferate and have a tendency to become cancerous. Developing methods to specifically target and remove these premalignant lesions is imperative to the prevention of malignant progression into gastrointestinal (GI) tumors. However, accurate detection and diagnosis of GI precancerous lesions is challenging, as these lesions show little or no structural change. Thus, this prevents early intervention and reduces the success rate of therapy. In this review, we performed a systematic analysis of the technological advancements in the combined application of nanovesicles (NVs) and the human interstitial fluid (HIF) to specifically target GI premalignant lesions. NVs, which include quantum dots (QDs), are small membranous vehicles of a nanometer diameter that are widely used as drug delivery vectors, therapeutic effectors and diagnostic sensors. HIF is the fluid that is present in human interstitial tissues (HITs) in which signaling molecules and agents travel and can be found throughout the body. HIF is exploited by tumor cells for their invasion, migration and spread. Because the HITs span the entire submucosa of the gastrointestinal tract, they have been increasingly targeted in GI tumor therapy. The challenges involved in the combined application of NVs and HIF in the detection, diagnosis, prognosis and therapy of GI premalignant lesions are also discussed.Keywords: gastrointestinal premalignant lesions, nanovesicles, human interstitium
format	article
author	Huang Y Deng X Liang J
author_facet	Huang Y Deng X Liang J
author_sort	Huang Y
title	Review of the Application of Nanovesicles and the Human Interstitial Fluid in Gastrointestinal Premalignant Lesion Detection, Diagnosis, Prognosis and Therapy
title_short	Review of the Application of Nanovesicles and the Human Interstitial Fluid in Gastrointestinal Premalignant Lesion Detection, Diagnosis, Prognosis and Therapy
title_full	Review of the Application of Nanovesicles and the Human Interstitial Fluid in Gastrointestinal Premalignant Lesion Detection, Diagnosis, Prognosis and Therapy
title_fullStr	Review of the Application of Nanovesicles and the Human Interstitial Fluid in Gastrointestinal Premalignant Lesion Detection, Diagnosis, Prognosis and Therapy
title_full_unstemmed	Review of the Application of Nanovesicles and the Human Interstitial Fluid in Gastrointestinal Premalignant Lesion Detection, Diagnosis, Prognosis and Therapy
title_sort	review of the application of nanovesicles and the human interstitial fluid in gastrointestinal premalignant lesion detection, diagnosis, prognosis and therapy
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/c1163aba451d4015859a9ae9b83a8631
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Review of the Application of Nanovesicles and the Human Interstitial Fluid in Gastrointestinal Premalignant Lesion Detection, Diagnosis, Prognosis and Therapy

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