Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line

This paper reports the synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives 5–8, obtained from the appropriate isatins with pyrrole, with good yields and purity. The product structures were confirmed through spectroscopy methods. Furthermore, the MTT assay on the human liver...

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Autores principales:	Santoso Mardi, Fadlan Arif, Fahmi Muhammad Riza Ghulam, Rahmayanti Ardhana
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	isatin isatin-pyrrole derivatives anticancer hepg2 cell line Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/c1178cb56fdc4d81a52514ff1686c7d5
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spelling	oai:doaj.org-article:c1178cb56fdc4d81a52514ff1686c7d52021-12-05T14:10:43ZSynthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line2391-542010.1515/chem-2021-0023https://doaj.org/article/c1178cb56fdc4d81a52514ff1686c7d52021-02-01T00:00:00Zhttps://doi.org/10.1515/chem-2021-0023https://doaj.org/toc/2391-5420This paper reports the synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives 5–8, obtained from the appropriate isatins with pyrrole, with good yields and purity. The product structures were confirmed through spectroscopy methods. Furthermore, the MTT assay on the human liver cancer HepG2 cell lines revealed moderate activity in all compounds, which was highest in sample 6 (IC50 0.47 µM). The anticancer activity was affiliated with the presence of a nitro group at C-5 and N-methyl of the isatin scaffold.Santoso MardiFadlan ArifFahmi Muhammad Riza GhulamRahmayanti ArdhanaDe Gruyterarticleisatinisatin-pyrrole derivativesanticancerhepg2 cell lineChemistryQD1-999ENOpen Chemistry, Vol 19, Iss 1, Pp 199-204 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	isatin isatin-pyrrole derivatives anticancer hepg2 cell line Chemistry QD1-999
spellingShingle	isatin isatin-pyrrole derivatives anticancer hepg2 cell line Chemistry QD1-999 Santoso Mardi Fadlan Arif Fahmi Muhammad Riza Ghulam Rahmayanti Ardhana Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line
description	This paper reports the synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives 5–8, obtained from the appropriate isatins with pyrrole, with good yields and purity. The product structures were confirmed through spectroscopy methods. Furthermore, the MTT assay on the human liver cancer HepG2 cell lines revealed moderate activity in all compounds, which was highest in sample 6 (IC50 0.47 µM). The anticancer activity was affiliated with the presence of a nitro group at C-5 and N-methyl of the isatin scaffold.
format	article
author	Santoso Mardi Fadlan Arif Fahmi Muhammad Riza Ghulam Rahmayanti Ardhana
author_facet	Santoso Mardi Fadlan Arif Fahmi Muhammad Riza Ghulam Rahmayanti Ardhana
author_sort	Santoso Mardi
title	Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line
title_short	Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line
title_full	Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line
title_fullStr	Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line
title_full_unstemmed	Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line
title_sort	synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against hepg2 cell line
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/c1178cb56fdc4d81a52514ff1686c7d5
work_keys_str_mv	AT santosomardi synthesisandinvitrocytotoxicityevaluationofisatinpyrrolederivativesagainsthepg2cellline AT fadlanarif synthesisandinvitrocytotoxicityevaluationofisatinpyrrolederivativesagainsthepg2cellline AT fahmimuhammadrizaghulam synthesisandinvitrocytotoxicityevaluationofisatinpyrrolederivativesagainsthepg2cellline AT rahmayantiardhana synthesisandinvitrocytotoxicityevaluationofisatinpyrrolederivativesagainsthepg2cellline
_version_	1718371806118674432

Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line

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