Nucleoporin Nup155 is part of the p53 network in liver cancer

Nucleoporin Nup155 is part of the p53 network in liver cancer

The nuclear pore complex (NPC) is known to regulate p53 signaling and this has mainly been linked to peripheral NPC subunits. Here the authors show that Nup155 from the NPC inner ring regulates the p53 pathway by controlling p21 translation while also being a target of p53-mediated repression.

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Bibliographic Details
Main Authors: Kerstin Holzer, Alessandro Ori, Amy Cooke, Daniel Dauch, Elisabeth Drucker, Philip Riemenschneider, Amparo Andres-Pons, Amanda L. DiGuilio, Marie-Therese Mackmull, Jochen Baßler, Stephanie Roessler, Kai Breuhahn, Lars Zender, Joseph S. Glavy, Frank Dombrowski, Ed Hurt, Peter Schirmacher, Martin Beck, Stephan Singer
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
Q
Online Access:https://doaj.org/article/c1189a48d95a485ea6f9e3a69d59c600
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Summary:The nuclear pore complex (NPC) is known to regulate p53 signaling and this has mainly been linked to peripheral NPC subunits. Here the authors show that Nup155 from the NPC inner ring regulates the p53 pathway by controlling p21 translation while also being a target of p53-mediated repression.

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