Nucleoporin Nup155 is part of the p53 network in liver cancer

The nuclear pore complex (NPC) is known to regulate p53 signaling and this has mainly been linked to peripheral NPC subunits. Here the authors show that Nup155 from the NPC inner ring regulates the p53 pathway by controlling p21 translation while also being a target of p53-mediated repression.

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Autores principales:	Kerstin Holzer, Alessandro Ori, Amy Cooke, Daniel Dauch, Elisabeth Drucker, Philip Riemenschneider, Amparo Andres-Pons, Amanda L. DiGuilio, Marie-Therese Mackmull, Jochen Baßler, Stephanie Roessler, Kai Breuhahn, Lars Zender, Joseph S. Glavy, Frank Dombrowski, Ed Hurt, Peter Schirmacher, Martin Beck, Stephan Singer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c1189a48d95a485ea6f9e3a69d59c600
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spelling	oai:doaj.org-article:c1189a48d95a485ea6f9e3a69d59c6002021-12-02T14:38:58ZNucleoporin Nup155 is part of the p53 network in liver cancer10.1038/s41467-019-10133-z2041-1723https://doaj.org/article/c1189a48d95a485ea6f9e3a69d59c6002019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10133-zhttps://doaj.org/toc/2041-1723The nuclear pore complex (NPC) is known to regulate p53 signaling and this has mainly been linked to peripheral NPC subunits. Here the authors show that Nup155 from the NPC inner ring regulates the p53 pathway by controlling p21 translation while also being a target of p53-mediated repression.Kerstin HolzerAlessandro OriAmy CookeDaniel DauchElisabeth DruckerPhilip RiemenschneiderAmparo Andres-PonsAmanda L. DiGuilioMarie-Therese MackmullJochen BaßlerStephanie RoesslerKai BreuhahnLars ZenderJoseph S. GlavyFrank DombrowskiEd HurtPeter SchirmacherMartin BeckStephan SingerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kerstin Holzer Alessandro Ori Amy Cooke Daniel Dauch Elisabeth Drucker Philip Riemenschneider Amparo Andres-Pons Amanda L. DiGuilio Marie-Therese Mackmull Jochen Baßler Stephanie Roessler Kai Breuhahn Lars Zender Joseph S. Glavy Frank Dombrowski Ed Hurt Peter Schirmacher Martin Beck Stephan Singer Nucleoporin Nup155 is part of the p53 network in liver cancer
description	The nuclear pore complex (NPC) is known to regulate p53 signaling and this has mainly been linked to peripheral NPC subunits. Here the authors show that Nup155 from the NPC inner ring regulates the p53 pathway by controlling p21 translation while also being a target of p53-mediated repression.
format	article
author	Kerstin Holzer Alessandro Ori Amy Cooke Daniel Dauch Elisabeth Drucker Philip Riemenschneider Amparo Andres-Pons Amanda L. DiGuilio Marie-Therese Mackmull Jochen Baßler Stephanie Roessler Kai Breuhahn Lars Zender Joseph S. Glavy Frank Dombrowski Ed Hurt Peter Schirmacher Martin Beck Stephan Singer
author_facet	Kerstin Holzer Alessandro Ori Amy Cooke Daniel Dauch Elisabeth Drucker Philip Riemenschneider Amparo Andres-Pons Amanda L. DiGuilio Marie-Therese Mackmull Jochen Baßler Stephanie Roessler Kai Breuhahn Lars Zender Joseph S. Glavy Frank Dombrowski Ed Hurt Peter Schirmacher Martin Beck Stephan Singer
author_sort	Kerstin Holzer
title	Nucleoporin Nup155 is part of the p53 network in liver cancer
title_short	Nucleoporin Nup155 is part of the p53 network in liver cancer
title_full	Nucleoporin Nup155 is part of the p53 network in liver cancer
title_fullStr	Nucleoporin Nup155 is part of the p53 network in liver cancer
title_full_unstemmed	Nucleoporin Nup155 is part of the p53 network in liver cancer
title_sort	nucleoporin nup155 is part of the p53 network in liver cancer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c1189a48d95a485ea6f9e3a69d59c600
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Nucleoporin Nup155 is part of the p53 network in liver cancer

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