Threshold Effects in the Relationship Between Serum Non-High-Density Lipoprotein Cholesterol and Metabolic Syndrome

Saibin Wang,1 Junwei Tu,1 Yibin Pan2 1Department of Respiratory Medicine, Jinhua Municipal Central Hospital, Jinhua, Zhejiang Province 321000, People’s Republic of China; 2Department of Cardiovascular Medicine, Jinhua Municipal Central Hospital, Jinhua, Zhejiang Province 321000, People&...

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Autores principales:	Wang S, Tu J, Pan Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	non-high-density lipoprotein cholesterol metabolic syndrome threshold effect lipid Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/c119dd84bfa2480a86111a4414965638
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spelling	oai:doaj.org-article:c119dd84bfa2480a86111a44149656382021-12-02T09:25:23ZThreshold Effects in the Relationship Between Serum Non-High-Density Lipoprotein Cholesterol and Metabolic Syndrome1178-7007https://doaj.org/article/c119dd84bfa2480a86111a44149656382019-11-01T00:00:00Zhttps://www.dovepress.com/threshold-effects-in-the-relationship-between-serum-non-high-density-l-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Saibin Wang,1 Junwei Tu,1 Yibin Pan2 1Department of Respiratory Medicine, Jinhua Municipal Central Hospital, Jinhua, Zhejiang Province 321000, People’s Republic of China; 2Department of Cardiovascular Medicine, Jinhua Municipal Central Hospital, Jinhua, Zhejiang Province 321000, People’s Republic of ChinaCorrespondence: Junwei TuDepartment of Respiratory Medicine, Jinhua Municipal Central Hospital, No. 365, East Renmin Road, Jinhua, Zhejiang Province 321000, People’s Republic of ChinaTel +86 579 82552278Fax +86 579 82325006Email junweiau@126.comYibin PanDepartment of Cardiovascular Medicine, Jinhua Municipal Central Hospital, No. 365, East Renmin Road, Jinhua, Zhejiang Province 321000, People’s Republic of ChinaTel +86 579 82552926Fax +86 579 82552927Email 18851733351@163.comBackground: Previous studies have suggested that the non-high-density lipoprotein cholesterol (non-HDL-C) is strongly associated with metabolic syndrome (MetS); however, the explicit relationship between them has not yet been clarified. The aim of this study was to reveal the explicit association between the non-HDL-C with MetS.Methods: The present study was based on a cross-sectional study, which was carried out in Spain. A total of 60,799 workers were recruited between 2012 and 2016. Anthropometric parameters and blood indices (lipid profile and fasting blood glucose) were collected. Participants were divided into the MetS group or the non-MetS group based on the criteria of the National Cholesterol Education Program Adult Treatment Panel III. The relationship between serum non-HDL-C and the risk of MetS was evaluated using multivariate regression analysis, piece-wise linear regression analysis, smooth curve fitting and threshold saturation effect analysis after adjustment of potential confounders.Results: The risk of developing MetS increased with increasing non-HDL-C level. However, this association was only presented in the range of the non-HDL-C concentrations from 118 mg/dl to 247 mg/dl after adjusting for potential confounders. When compared to lower non-HDL-C level (247 mg/dl) were related to higher incidence of MetS, with adjusted odds ratio (95% confidence interval) of 3.08 (2.77, 3.42) and 17.18 (14.29, 20.65), respectively (P for trend <0.05).Conclusion: Higher serum non-HDL-C level was associated with increased MetS incidence; however, significant threshold saturation effects were observed when the non-HDL-C level 247 mg/dl.Keywords: non-high-density lipoprotein cholesterol, metabolic syndrome, threshold effect, lipidWang STu JPan YDove Medical Pressarticlenon-high-density lipoprotein cholesterolmetabolic syndromethreshold effectlipidSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 2501-2506 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	non-high-density lipoprotein cholesterol metabolic syndrome threshold effect lipid Specialties of internal medicine RC581-951
spellingShingle	non-high-density lipoprotein cholesterol metabolic syndrome threshold effect lipid Specialties of internal medicine RC581-951 Wang S Tu J Pan Y Threshold Effects in the Relationship Between Serum Non-High-Density Lipoprotein Cholesterol and Metabolic Syndrome
description	Saibin Wang,1 Junwei Tu,1 Yibin Pan2 1Department of Respiratory Medicine, Jinhua Municipal Central Hospital, Jinhua, Zhejiang Province 321000, People’s Republic of China; 2Department of Cardiovascular Medicine, Jinhua Municipal Central Hospital, Jinhua, Zhejiang Province 321000, People’s Republic of ChinaCorrespondence: Junwei TuDepartment of Respiratory Medicine, Jinhua Municipal Central Hospital, No. 365, East Renmin Road, Jinhua, Zhejiang Province 321000, People’s Republic of ChinaTel +86 579 82552278Fax +86 579 82325006Email junweiau@126.comYibin PanDepartment of Cardiovascular Medicine, Jinhua Municipal Central Hospital, No. 365, East Renmin Road, Jinhua, Zhejiang Province 321000, People’s Republic of ChinaTel +86 579 82552926Fax +86 579 82552927Email 18851733351@163.comBackground: Previous studies have suggested that the non-high-density lipoprotein cholesterol (non-HDL-C) is strongly associated with metabolic syndrome (MetS); however, the explicit relationship between them has not yet been clarified. The aim of this study was to reveal the explicit association between the non-HDL-C with MetS.Methods: The present study was based on a cross-sectional study, which was carried out in Spain. A total of 60,799 workers were recruited between 2012 and 2016. Anthropometric parameters and blood indices (lipid profile and fasting blood glucose) were collected. Participants were divided into the MetS group or the non-MetS group based on the criteria of the National Cholesterol Education Program Adult Treatment Panel III. The relationship between serum non-HDL-C and the risk of MetS was evaluated using multivariate regression analysis, piece-wise linear regression analysis, smooth curve fitting and threshold saturation effect analysis after adjustment of potential confounders.Results: The risk of developing MetS increased with increasing non-HDL-C level. However, this association was only presented in the range of the non-HDL-C concentrations from 118 mg/dl to 247 mg/dl after adjusting for potential confounders. When compared to lower non-HDL-C level (247 mg/dl) were related to higher incidence of MetS, with adjusted odds ratio (95% confidence interval) of 3.08 (2.77, 3.42) and 17.18 (14.29, 20.65), respectively (P for trend <0.05).Conclusion: Higher serum non-HDL-C level was associated with increased MetS incidence; however, significant threshold saturation effects were observed when the non-HDL-C level 247 mg/dl.Keywords: non-high-density lipoprotein cholesterol, metabolic syndrome, threshold effect, lipid
format	article
author	Wang S Tu J Pan Y
author_facet	Wang S Tu J Pan Y
author_sort	Wang S
title	Threshold Effects in the Relationship Between Serum Non-High-Density Lipoprotein Cholesterol and Metabolic Syndrome
title_short	Threshold Effects in the Relationship Between Serum Non-High-Density Lipoprotein Cholesterol and Metabolic Syndrome
title_full	Threshold Effects in the Relationship Between Serum Non-High-Density Lipoprotein Cholesterol and Metabolic Syndrome
title_fullStr	Threshold Effects in the Relationship Between Serum Non-High-Density Lipoprotein Cholesterol and Metabolic Syndrome
title_full_unstemmed	Threshold Effects in the Relationship Between Serum Non-High-Density Lipoprotein Cholesterol and Metabolic Syndrome
title_sort	threshold effects in the relationship between serum non-high-density lipoprotein cholesterol and metabolic syndrome
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/c119dd84bfa2480a86111a4414965638
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Threshold Effects in the Relationship Between Serum Non-High-Density Lipoprotein Cholesterol and Metabolic Syndrome

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