Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors

Molecular mechanisms that control the division of neural progenitor cells are only partially understood. Here the authors show that Diaph3 is critical for spindle checkpoint activity in cortical progenitor cells as the loss of Diaph3 leads to apoptosis of progenitor cells and eventually results in m...

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Autores principales:	Devid Damiani, André M. Goffinet, Arthur Alberts, Fadel Tissir
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c11a93950379466dbfd85bd0c23e5955
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spelling	oai:doaj.org-article:c11a93950379466dbfd85bd0c23e59552021-12-02T16:49:40ZLack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors10.1038/ncomms135092041-1723https://doaj.org/article/c11a93950379466dbfd85bd0c23e59552016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13509https://doaj.org/toc/2041-1723Molecular mechanisms that control the division of neural progenitor cells are only partially understood. Here the authors show that Diaph3 is critical for spindle checkpoint activity in cortical progenitor cells as the loss of Diaph3 leads to apoptosis of progenitor cells and eventually results in microcephaly in mice.Devid DamianiAndré M. GoffinetArthur AlbertsFadel TissirNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Devid Damiani André M. Goffinet Arthur Alberts Fadel Tissir Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors
description	Molecular mechanisms that control the division of neural progenitor cells are only partially understood. Here the authors show that Diaph3 is critical for spindle checkpoint activity in cortical progenitor cells as the loss of Diaph3 leads to apoptosis of progenitor cells and eventually results in microcephaly in mice.
format	article
author	Devid Damiani André M. Goffinet Arthur Alberts Fadel Tissir
author_facet	Devid Damiani André M. Goffinet Arthur Alberts Fadel Tissir
author_sort	Devid Damiani
title	Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors
title_short	Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors
title_full	Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors
title_fullStr	Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors
title_full_unstemmed	Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors
title_sort	lack of diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c11a93950379466dbfd85bd0c23e5955
work_keys_str_mv	AT deviddamiani lackofdiaph3relaxesthespindlecheckpointcausingthelossofneuralprogenitors AT andremgoffinet lackofdiaph3relaxesthespindlecheckpointcausingthelossofneuralprogenitors AT arthuralberts lackofdiaph3relaxesthespindlecheckpointcausingthelossofneuralprogenitors AT fadeltissir lackofdiaph3relaxesthespindlecheckpointcausingthelossofneuralprogenitors
_version_	1718383237932253184

Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors

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