Superoxide dismutase and the sigma1 receptor as key elements of the antioxidant system in human gastrointestinal tract cancers

This long-term research was designed to evaluate whether superoxide dismutase (SOD) isoenzymes participate in the development of human gastrointestinal neoplasms and the potential influence of the sigma1 receptor (Sig1R) on the regulation of SOD gene expression during the neoplastic process. The exp...

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Autor principal:	Skrzycki Michał
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	superoxide dismutase sigma1 receptor gastrointestinal cancer oxidative stress antioxidant enzymes Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c11c3b7f13204115b98f09947c5b75dc
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spelling	oai:doaj.org-article:c11c3b7f13204115b98f09947c5b75dc2021-12-05T14:10:42ZSuperoxide dismutase and the sigma1 receptor as key elements of the antioxidant system in human gastrointestinal tract cancers2391-541210.1515/biol-2021-0124https://doaj.org/article/c11c3b7f13204115b98f09947c5b75dc2021-11-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0124https://doaj.org/toc/2391-5412This long-term research was designed to evaluate whether superoxide dismutase (SOD) isoenzymes participate in the development of human gastrointestinal neoplasms and the potential influence of the sigma1 receptor (Sig1R) on the regulation of SOD gene expression during the neoplastic process. The experiments included human tissues from selected gastrointestinal tract tumors (liver cancer, colorectal adenocarcinoma, and colorectal cancer liver metastases). Activity, protein levels, and mRNA levels were determined for SOD isoenzymes and Sig1R. Additionally, markers of oxidative stress (glutathione, lipid peroxidation) were measured. The results showed significant changes in the antioxidant system activity in all examined types of tumors. SOD changed both in healthy cells and in neoplastic cells. The activity and expression of all studied enzymes significantly changed due to the advancement of tumor development. The Sig1R might be an additional regulator of the antioxidant system on which activity might depend on the survival and proliferation of cancer cells. Overall, the study shows that SOD1 and SOD2 are involved not only in the formation of neoplastic changes in the human gastrointestinal tissues (healthy intestine – colon tumor; healthy liver – liver cirrhosis – liver cancer) but also in the development of tumors in the sequence: benign tumor – malignant tumor – metastasis.Skrzycki MichałDe Gruyterarticlesuperoxide dismutasesigma1 receptorgastrointestinal canceroxidative stressantioxidant enzymesBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 1225-1239 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	superoxide dismutase sigma1 receptor gastrointestinal cancer oxidative stress antioxidant enzymes Biology (General) QH301-705.5
spellingShingle	superoxide dismutase sigma1 receptor gastrointestinal cancer oxidative stress antioxidant enzymes Biology (General) QH301-705.5 Skrzycki Michał Superoxide dismutase and the sigma1 receptor as key elements of the antioxidant system in human gastrointestinal tract cancers
description	This long-term research was designed to evaluate whether superoxide dismutase (SOD) isoenzymes participate in the development of human gastrointestinal neoplasms and the potential influence of the sigma1 receptor (Sig1R) on the regulation of SOD gene expression during the neoplastic process. The experiments included human tissues from selected gastrointestinal tract tumors (liver cancer, colorectal adenocarcinoma, and colorectal cancer liver metastases). Activity, protein levels, and mRNA levels were determined for SOD isoenzymes and Sig1R. Additionally, markers of oxidative stress (glutathione, lipid peroxidation) were measured. The results showed significant changes in the antioxidant system activity in all examined types of tumors. SOD changed both in healthy cells and in neoplastic cells. The activity and expression of all studied enzymes significantly changed due to the advancement of tumor development. The Sig1R might be an additional regulator of the antioxidant system on which activity might depend on the survival and proliferation of cancer cells. Overall, the study shows that SOD1 and SOD2 are involved not only in the formation of neoplastic changes in the human gastrointestinal tissues (healthy intestine – colon tumor; healthy liver – liver cirrhosis – liver cancer) but also in the development of tumors in the sequence: benign tumor – malignant tumor – metastasis.
format	article
author	Skrzycki Michał
author_facet	Skrzycki Michał
author_sort	Skrzycki Michał
title	Superoxide dismutase and the sigma1 receptor as key elements of the antioxidant system in human gastrointestinal tract cancers
title_short	Superoxide dismutase and the sigma1 receptor as key elements of the antioxidant system in human gastrointestinal tract cancers
title_full	Superoxide dismutase and the sigma1 receptor as key elements of the antioxidant system in human gastrointestinal tract cancers
title_fullStr	Superoxide dismutase and the sigma1 receptor as key elements of the antioxidant system in human gastrointestinal tract cancers
title_full_unstemmed	Superoxide dismutase and the sigma1 receptor as key elements of the antioxidant system in human gastrointestinal tract cancers
title_sort	superoxide dismutase and the sigma1 receptor as key elements of the antioxidant system in human gastrointestinal tract cancers
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/c11c3b7f13204115b98f09947c5b75dc
work_keys_str_mv	AT skrzyckimichał superoxidedismutaseandthesigma1receptoraskeyelementsoftheantioxidantsysteminhumangastrointestinaltractcancers
_version_	1718371806312660992

Superoxide dismutase and the sigma1 receptor as key elements of the antioxidant system in human gastrointestinal tract cancers

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