NAMPT-derived NAD+ fuels PARP1 to promote skin inflammation through parthanatos cell death.

NAMPT-derived NAD+ fuels PARP1 to promote skin inflammation through parthanatos cell death.

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Several studies have revealed a correlation between chronic inflammation and nicotinamide adenine dinucleotide (NAD+) metabolism, but the precise mechanism involved is unknown. Here, we report that the genetic and pharmacological inhibition of nicotinamide phosphoribosyltransferase (Nampt), the rate...

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Detalles Bibliográficos
Autores principales: Francisco J Martínez-Morcillo, Joaquín Cantón-Sandoval, Francisco J Martínez-Navarro, Isabel Cabas, Idoya Martínez-Vicente, Joy Armistead, Julia Hatzold, Azucena López-Muñoz, Teresa Martínez-Menchón, Raúl Corbalán-Vélez, Jesús Lacal, Matthias Hammerschmidt, José C García-Borrón, Alfonsa García-Ayala, María L Cayuela, Ana B Pérez-Oliva, Diana García-Moreno, Victoriano Mulero
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/c11ffb29a8224682bfa3649726698558
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