Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway

Ferroptosis is an iron-dependent mechanism of cell death. In this mouse study, the authors show that diets high in iron or depletion of the antioxidant Gpx4 potentiates pancreatic damage and tumour formation by activating the DNA damage pathway and recruiting macrophages to the pancreas.

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Autores principales:	Enyong Dai, Leng Han, Jiao Liu, Yangchun Xie, Herbert J. Zeh, Rui Kang, Lulu Bai, Daolin Tang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c121a8ce021a465cb09de4318e23669d
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spelling	oai:doaj.org-article:c121a8ce021a465cb09de4318e23669d2021-12-02T10:48:19ZFerroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway10.1038/s41467-020-20154-82041-1723https://doaj.org/article/c121a8ce021a465cb09de4318e23669d2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20154-8https://doaj.org/toc/2041-1723Ferroptosis is an iron-dependent mechanism of cell death. In this mouse study, the authors show that diets high in iron or depletion of the antioxidant Gpx4 potentiates pancreatic damage and tumour formation by activating the DNA damage pathway and recruiting macrophages to the pancreas.Enyong DaiLeng HanJiao LiuYangchun XieHerbert J. ZehRui KangLulu BaiDaolin TangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Enyong Dai Leng Han Jiao Liu Yangchun Xie Herbert J. Zeh Rui Kang Lulu Bai Daolin Tang Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway
description	Ferroptosis is an iron-dependent mechanism of cell death. In this mouse study, the authors show that diets high in iron or depletion of the antioxidant Gpx4 potentiates pancreatic damage and tumour formation by activating the DNA damage pathway and recruiting macrophages to the pancreas.
format	article
author	Enyong Dai Leng Han Jiao Liu Yangchun Xie Herbert J. Zeh Rui Kang Lulu Bai Daolin Tang
author_facet	Enyong Dai Leng Han Jiao Liu Yangchun Xie Herbert J. Zeh Rui Kang Lulu Bai Daolin Tang
author_sort	Enyong Dai
title	Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway
title_short	Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway
title_full	Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway
title_fullStr	Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway
title_full_unstemmed	Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway
title_sort	ferroptotic damage promotes pancreatic tumorigenesis through a tmem173/sting-dependent dna sensor pathway
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c121a8ce021a465cb09de4318e23669d
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Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway

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