Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation.
<h4>Background</h4>Microglial cell activation and cerebral function impairment are described in both chronic hepatitis C viral (HCV) and Human-Immune-Deficiency viral (HIV) infections. The aim of this study was to investigate the effect of acute HCV infection upon cerebral function and m...
Guardado en:
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2012
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/c124816a84824d139ceb07f51771943e |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:c124816a84824d139ceb07f51771943e |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:c124816a84824d139ceb07f51771943e2021-11-18T07:12:42ZAcute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation.1932-620310.1371/journal.pone.0038980https://doaj.org/article/c124816a84824d139ceb07f51771943e2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22808022/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Microglial cell activation and cerebral function impairment are described in both chronic hepatitis C viral (HCV) and Human-Immune-Deficiency viral (HIV) infections. The aim of this study was to investigate the effect of acute HCV infection upon cerebral function and microglial cell activation in HIV-infected individuals.<h4>Methods</h4>A case-control study was conducted. Subjects with acute HCV and chronic HIV coinfection (aHCV) were compared to matched controls with chronic HIV monoinfection (HIVmono). aHCV was defined as a new positive plasma HCV RNA within 12 months of a negative RNA test. Subjects underwent neuro-cognitive testing (NCT), cerebral proton magnetic resonance spectroscopy ((1)H-MRS) and positron emission tomography (PET) using a (11)C-radiolabeled ligand (PK11195), which is highly specific for translocator protein 18 kDA receptors on activated microglial cells. Differences between cases and controls were assessed using linear regression modelling.<h4>Results</h4>Twenty-four aHCV cases completed NCT and (1)H-MRS, 8 underwent PET. Of 57 HIVmono controls completing NCT, 12 underwent (1)H-MRS and 8 PET. Subjects with aHCV demonstrated on NCT, significantly poorer executive function (mean (SD) error rate 26.50(17.87) versus 19.09(8.12), p = 0.001) and on (1)H-MRS increased myo-inositol/creatine ratios (mI/Cr, a marker of cerebral inflammation) in the basal ganglia (ratio of 0.71(0.22) versus 0.55(0.23), p = 0.03), compared to subjects with HIVmono. On PET imaging, no difference in (11)C-PK11195 binding potential (BP) was observed between study groups (p>0.10 all cerebral locations), however lower BPs were associated with combination antiretroviral therapy (cART) use in the parietal (p = 0.01) and frontal (p = 0.03) cerebral locations.<h4>Discussion</h4>Poorer cognitive performance and disturbance of cerebral metabolites are observed in subjects with aHC,V compared to subjects with HIVmono. Higher (11)C-PK11195 BP was not observed in subjects with aHCV, but was observed in subjects not on cART.Lucy J GarveyNicola PaveseAnil RamlackhansinghEmma ThomsonJoanna M AllsopMarios PolitisRanjababu KulasegaramJanice MainDavid J BrooksSimon D Taylor-RobinsonAlan WinstonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e38980 (2012) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Lucy J Garvey Nicola Pavese Anil Ramlackhansingh Emma Thomson Joanna M Allsop Marios Politis Ranjababu Kulasegaram Janice Main David J Brooks Simon D Taylor-Robinson Alan Winston Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation. |
| description |
<h4>Background</h4>Microglial cell activation and cerebral function impairment are described in both chronic hepatitis C viral (HCV) and Human-Immune-Deficiency viral (HIV) infections. The aim of this study was to investigate the effect of acute HCV infection upon cerebral function and microglial cell activation in HIV-infected individuals.<h4>Methods</h4>A case-control study was conducted. Subjects with acute HCV and chronic HIV coinfection (aHCV) were compared to matched controls with chronic HIV monoinfection (HIVmono). aHCV was defined as a new positive plasma HCV RNA within 12 months of a negative RNA test. Subjects underwent neuro-cognitive testing (NCT), cerebral proton magnetic resonance spectroscopy ((1)H-MRS) and positron emission tomography (PET) using a (11)C-radiolabeled ligand (PK11195), which is highly specific for translocator protein 18 kDA receptors on activated microglial cells. Differences between cases and controls were assessed using linear regression modelling.<h4>Results</h4>Twenty-four aHCV cases completed NCT and (1)H-MRS, 8 underwent PET. Of 57 HIVmono controls completing NCT, 12 underwent (1)H-MRS and 8 PET. Subjects with aHCV demonstrated on NCT, significantly poorer executive function (mean (SD) error rate 26.50(17.87) versus 19.09(8.12), p = 0.001) and on (1)H-MRS increased myo-inositol/creatine ratios (mI/Cr, a marker of cerebral inflammation) in the basal ganglia (ratio of 0.71(0.22) versus 0.55(0.23), p = 0.03), compared to subjects with HIVmono. On PET imaging, no difference in (11)C-PK11195 binding potential (BP) was observed between study groups (p>0.10 all cerebral locations), however lower BPs were associated with combination antiretroviral therapy (cART) use in the parietal (p = 0.01) and frontal (p = 0.03) cerebral locations.<h4>Discussion</h4>Poorer cognitive performance and disturbance of cerebral metabolites are observed in subjects with aHC,V compared to subjects with HIVmono. Higher (11)C-PK11195 BP was not observed in subjects with aHCV, but was observed in subjects not on cART. |
| format |
article |
| author |
Lucy J Garvey Nicola Pavese Anil Ramlackhansingh Emma Thomson Joanna M Allsop Marios Politis Ranjababu Kulasegaram Janice Main David J Brooks Simon D Taylor-Robinson Alan Winston |
| author_facet |
Lucy J Garvey Nicola Pavese Anil Ramlackhansingh Emma Thomson Joanna M Allsop Marios Politis Ranjababu Kulasegaram Janice Main David J Brooks Simon D Taylor-Robinson Alan Winston |
| author_sort |
Lucy J Garvey |
| title |
Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation. |
| title_short |
Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation. |
| title_full |
Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation. |
| title_fullStr |
Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation. |
| title_full_unstemmed |
Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation. |
| title_sort |
acute hcv/hiv coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/c124816a84824d139ceb07f51771943e |
| work_keys_str_mv |
AT lucyjgarvey acutehcvhivcoinfectionisassociatedwithcognitivedysfunctionandcerebralmetabolitedisturbancebutnotincreasedmicroglialcellactivation AT nicolapavese acutehcvhivcoinfectionisassociatedwithcognitivedysfunctionandcerebralmetabolitedisturbancebutnotincreasedmicroglialcellactivation AT anilramlackhansingh acutehcvhivcoinfectionisassociatedwithcognitivedysfunctionandcerebralmetabolitedisturbancebutnotincreasedmicroglialcellactivation AT emmathomson acutehcvhivcoinfectionisassociatedwithcognitivedysfunctionandcerebralmetabolitedisturbancebutnotincreasedmicroglialcellactivation AT joannamallsop acutehcvhivcoinfectionisassociatedwithcognitivedysfunctionandcerebralmetabolitedisturbancebutnotincreasedmicroglialcellactivation AT mariospolitis acutehcvhivcoinfectionisassociatedwithcognitivedysfunctionandcerebralmetabolitedisturbancebutnotincreasedmicroglialcellactivation AT ranjababukulasegaram acutehcvhivcoinfectionisassociatedwithcognitivedysfunctionandcerebralmetabolitedisturbancebutnotincreasedmicroglialcellactivation AT janicemain acutehcvhivcoinfectionisassociatedwithcognitivedysfunctionandcerebralmetabolitedisturbancebutnotincreasedmicroglialcellactivation AT davidjbrooks acutehcvhivcoinfectionisassociatedwithcognitivedysfunctionandcerebralmetabolitedisturbancebutnotincreasedmicroglialcellactivation AT simondtaylorrobinson acutehcvhivcoinfectionisassociatedwithcognitivedysfunctionandcerebralmetabolitedisturbancebutnotincreasedmicroglialcellactivation AT alanwinston acutehcvhivcoinfectionisassociatedwithcognitivedysfunctionandcerebralmetabolitedisturbancebutnotincreasedmicroglialcellactivation |
| _version_ |
1718423814152388608 |