Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF

Hair can be regenerated after skin wounding. Here the authors show that inflammatory macrophages produce TNF that activates Wnt signalling in hair follicle stem cells to drive this hair regeneration after wound repair in mice.

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Detalles Bibliográficos
Autores principales:	Xusheng Wang, Haiyan Chen, Ruiyun Tian, Yiling Zhang, Marina S. Drutskaya, Chengmei Wang, Jianfeng Ge, Zhimeng Fan, Deqiang Kong, Xiaoxiao Wang, Ting Cai, Ying Zhou, Jingwen Wang, Jinmei Wang, Shan Wang, Zhihai Qin, Huanhuan Jia, Yue Wu, Jia Liu, Sergei A. Nedospasov, Edward E. Tredget, Mei Lin, Jianjun Liu, Yuyang Jiang, Yaojiong Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c1280a37456c4ba7b643279d85e82d64
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:c1280a37456c4ba7b643279d85e82d642021-12-02T15:38:35ZMacrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF10.1038/ncomms140912041-1723https://doaj.org/article/c1280a37456c4ba7b643279d85e82d642017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14091https://doaj.org/toc/2041-1723Hair can be regenerated after skin wounding. Here the authors show that inflammatory macrophages produce TNF that activates Wnt signalling in hair follicle stem cells to drive this hair regeneration after wound repair in mice.Xusheng WangHaiyan ChenRuiyun TianYiling ZhangMarina S. DrutskayaChengmei WangJianfeng GeZhimeng FanDeqiang KongXiaoxiao WangTing CaiYing ZhouJingwen WangJinmei WangShan WangZhihai QinHuanhuan JiaYue WuJia LiuSergei A. NedospasovEdward E. TredgetMei LinJianjun LiuYuyang JiangYaojiong WuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xusheng Wang Haiyan Chen Ruiyun Tian Yiling Zhang Marina S. Drutskaya Chengmei Wang Jianfeng Ge Zhimeng Fan Deqiang Kong Xiaoxiao Wang Ting Cai Ying Zhou Jingwen Wang Jinmei Wang Shan Wang Zhihai Qin Huanhuan Jia Yue Wu Jia Liu Sergei A. Nedospasov Edward E. Tredget Mei Lin Jianjun Liu Yuyang Jiang Yaojiong Wu Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF
description	Hair can be regenerated after skin wounding. Here the authors show that inflammatory macrophages produce TNF that activates Wnt signalling in hair follicle stem cells to drive this hair regeneration after wound repair in mice.
format	article
author	Xusheng Wang Haiyan Chen Ruiyun Tian Yiling Zhang Marina S. Drutskaya Chengmei Wang Jianfeng Ge Zhimeng Fan Deqiang Kong Xiaoxiao Wang Ting Cai Ying Zhou Jingwen Wang Jinmei Wang Shan Wang Zhihai Qin Huanhuan Jia Yue Wu Jia Liu Sergei A. Nedospasov Edward E. Tredget Mei Lin Jianjun Liu Yuyang Jiang Yaojiong Wu
author_facet	Xusheng Wang Haiyan Chen Ruiyun Tian Yiling Zhang Marina S. Drutskaya Chengmei Wang Jianfeng Ge Zhimeng Fan Deqiang Kong Xiaoxiao Wang Ting Cai Ying Zhou Jingwen Wang Jinmei Wang Shan Wang Zhihai Qin Huanhuan Jia Yue Wu Jia Liu Sergei A. Nedospasov Edward E. Tredget Mei Lin Jianjun Liu Yuyang Jiang Yaojiong Wu
author_sort	Xusheng Wang
title	Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF
title_short	Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF
title_full	Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF
title_fullStr	Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF
title_full_unstemmed	Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF
title_sort	macrophages induce akt/β-catenin-dependent lgr5+ stem cell activation and hair follicle regeneration through tnf
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c1280a37456c4ba7b643279d85e82d64
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Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF

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