Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension

TRPV4 dominant mutations cause neuropathy. Here, the authors show that TRPV4 binds and interacts with RhoA, modulating the actin cytoskeleton. Neuropathy-causing mutations of TRPV4 disrupt this complex, leading to RhoA activation and impairment of neurite extension in cultured cells and flies.

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Autores principales:	Brett A. McCray, Erika Diehl, Jeremy M. Sullivan, William H. Aisenberg, Nicholas W. Zaccor, Alexander R. Lau, Dominick J. Rich, Benedikt Goretzki, Ute A. Hellmich, Thomas E. Lloyd, Charlotte J. Sumner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c12c32fb25af4c0fbec8907050b017a1
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spelling	oai:doaj.org-article:c12c32fb25af4c0fbec8907050b017a12021-12-02T13:33:01ZNeuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension10.1038/s41467-021-21699-y2041-1723https://doaj.org/article/c12c32fb25af4c0fbec8907050b017a12021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21699-yhttps://doaj.org/toc/2041-1723TRPV4 dominant mutations cause neuropathy. Here, the authors show that TRPV4 binds and interacts with RhoA, modulating the actin cytoskeleton. Neuropathy-causing mutations of TRPV4 disrupt this complex, leading to RhoA activation and impairment of neurite extension in cultured cells and flies.Brett A. McCrayErika DiehlJeremy M. SullivanWilliam H. AisenbergNicholas W. ZaccorAlexander R. LauDominick J. RichBenedikt GoretzkiUte A. HellmichThomas E. LloydCharlotte J. SumnerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brett A. McCray Erika Diehl Jeremy M. Sullivan William H. Aisenberg Nicholas W. Zaccor Alexander R. Lau Dominick J. Rich Benedikt Goretzki Ute A. Hellmich Thomas E. Lloyd Charlotte J. Sumner Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension
description	TRPV4 dominant mutations cause neuropathy. Here, the authors show that TRPV4 binds and interacts with RhoA, modulating the actin cytoskeleton. Neuropathy-causing mutations of TRPV4 disrupt this complex, leading to RhoA activation and impairment of neurite extension in cultured cells and flies.
format	article
author	Brett A. McCray Erika Diehl Jeremy M. Sullivan William H. Aisenberg Nicholas W. Zaccor Alexander R. Lau Dominick J. Rich Benedikt Goretzki Ute A. Hellmich Thomas E. Lloyd Charlotte J. Sumner
author_facet	Brett A. McCray Erika Diehl Jeremy M. Sullivan William H. Aisenberg Nicholas W. Zaccor Alexander R. Lau Dominick J. Rich Benedikt Goretzki Ute A. Hellmich Thomas E. Lloyd Charlotte J. Sumner
author_sort	Brett A. McCray
title	Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension
title_short	Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension
title_full	Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension
title_fullStr	Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension
title_full_unstemmed	Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension
title_sort	neuropathy-causing trpv4 mutations disrupt trpv4-rhoa interactions and impair neurite extension
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c12c32fb25af4c0fbec8907050b017a1
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Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension

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