Regulation of angiotensin II actions by enhancers and super-enhancers in vascular smooth muscle cells

The repertoire of tissue-specific distal regulators of gene transcription enhancers defines homeostasis or disease. Here, the authors reveal the enhancer and super-enhancer signature of vascular smooth muscle cells under normal and angiotensin II stimuli, providing new insight into the transcription...

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Autores principales: Sadhan Das, Parijat Senapati, Zhuo Chen, Marpadga A. Reddy, Rituparna Ganguly, Linda Lanting, Varun Mandi, Anita Bansal, Amy Leung, Selena Zhang, Ye Jia, Xiwei Wu, Dustin E. Schones, Rama Natarajan
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/c12c799c38c64e36a32adeb8061e24ec
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spelling oai:doaj.org-article:c12c799c38c64e36a32adeb8061e24ec2021-12-02T16:51:52ZRegulation of angiotensin II actions by enhancers and super-enhancers in vascular smooth muscle cells10.1038/s41467-017-01629-72041-1723https://doaj.org/article/c12c799c38c64e36a32adeb8061e24ec2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01629-7https://doaj.org/toc/2041-1723The repertoire of tissue-specific distal regulators of gene transcription enhancers defines homeostasis or disease. Here, the authors reveal the enhancer and super-enhancer signature of vascular smooth muscle cells under normal and angiotensin II stimuli, providing new insight into the transcriptional regulation of vascular pathologies.Sadhan DasParijat SenapatiZhuo ChenMarpadga A. ReddyRituparna GangulyLinda LantingVarun MandiAnita BansalAmy LeungSelena ZhangYe JiaXiwei WuDustin E. SchonesRama NatarajanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sadhan Das
Parijat Senapati
Zhuo Chen
Marpadga A. Reddy
Rituparna Ganguly
Linda Lanting
Varun Mandi
Anita Bansal
Amy Leung
Selena Zhang
Ye Jia
Xiwei Wu
Dustin E. Schones
Rama Natarajan
Regulation of angiotensin II actions by enhancers and super-enhancers in vascular smooth muscle cells
description The repertoire of tissue-specific distal regulators of gene transcription enhancers defines homeostasis or disease. Here, the authors reveal the enhancer and super-enhancer signature of vascular smooth muscle cells under normal and angiotensin II stimuli, providing new insight into the transcriptional regulation of vascular pathologies.
format article
author Sadhan Das
Parijat Senapati
Zhuo Chen
Marpadga A. Reddy
Rituparna Ganguly
Linda Lanting
Varun Mandi
Anita Bansal
Amy Leung
Selena Zhang
Ye Jia
Xiwei Wu
Dustin E. Schones
Rama Natarajan
author_facet Sadhan Das
Parijat Senapati
Zhuo Chen
Marpadga A. Reddy
Rituparna Ganguly
Linda Lanting
Varun Mandi
Anita Bansal
Amy Leung
Selena Zhang
Ye Jia
Xiwei Wu
Dustin E. Schones
Rama Natarajan
author_sort Sadhan Das
title Regulation of angiotensin II actions by enhancers and super-enhancers in vascular smooth muscle cells
title_short Regulation of angiotensin II actions by enhancers and super-enhancers in vascular smooth muscle cells
title_full Regulation of angiotensin II actions by enhancers and super-enhancers in vascular smooth muscle cells
title_fullStr Regulation of angiotensin II actions by enhancers and super-enhancers in vascular smooth muscle cells
title_full_unstemmed Regulation of angiotensin II actions by enhancers and super-enhancers in vascular smooth muscle cells
title_sort regulation of angiotensin ii actions by enhancers and super-enhancers in vascular smooth muscle cells
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/c12c799c38c64e36a32adeb8061e24ec
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