METHYLATION OF CELLULAR DNA AND PATHOLOGY OF THE ORGANISM

Abstract. In spite of stable opinions concerning clear pathogenetic differences in main disease states (i.e., cancer, atherosclerosis, autoimmune and allergic diseases), there are sufficient reasons to assume some fundamental processes, that are common to development of these diseases, and represent...

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Autor principal:	V. A. Kozlov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	methylation dna histones acetylation gene Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/c12e641d92ea420093898ed79fd939ed
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spelling	oai:doaj.org-article:c12e641d92ea420093898ed79fd939ed2021-11-18T08:03:38ZMETHYLATION OF CELLULAR DNA AND PATHOLOGY OF THE ORGANISM1563-06252313-741X10.15789/1563-0625-2008-4-5-307-318https://doaj.org/article/c12e641d92ea420093898ed79fd939ed2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/178https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. In spite of stable opinions concerning clear pathogenetic differences in main disease states (i.e., cancer, atherosclerosis, autoimmune and allergic diseases), there are sufficient reasons to assume some fundamental processes, that are common to development of these diseases, and represent a general factor of their pathogenesis. Such processes include, e.g., DNA methylation and demethylation events, acetylation and deacetylation of histones, the processes of telomere shortening connected with telomerase activity. It proves that, at least, cancer, atherosclerosis, and autoimmune diseases are characterized by total hypomethylation of different cellular elements, against «recurrent» DNA hypermethylation of single specific genes in the background. It is assumed that information about such common developmental mechanisms for different disease states may evoke an issue of a search for some common approaches to treatment of these diseases, along with elaboration of conventional treatment modalities, being specific to individual pathology. (Med. Immunol., vol. 10, N 4-5, pp 307-318).V. A. KozlovSPb RAACIarticlemethylationdnahistonesacetylationgeneImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 4-5, Pp 307-318 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	methylation dna histones acetylation gene Immunologic diseases. Allergy RC581-607
spellingShingle	methylation dna histones acetylation gene Immunologic diseases. Allergy RC581-607 V. A. Kozlov METHYLATION OF CELLULAR DNA AND PATHOLOGY OF THE ORGANISM
description	Abstract. In spite of stable opinions concerning clear pathogenetic differences in main disease states (i.e., cancer, atherosclerosis, autoimmune and allergic diseases), there are sufficient reasons to assume some fundamental processes, that are common to development of these diseases, and represent a general factor of their pathogenesis. Such processes include, e.g., DNA methylation and demethylation events, acetylation and deacetylation of histones, the processes of telomere shortening connected with telomerase activity. It proves that, at least, cancer, atherosclerosis, and autoimmune diseases are characterized by total hypomethylation of different cellular elements, against «recurrent» DNA hypermethylation of single specific genes in the background. It is assumed that information about such common developmental mechanisms for different disease states may evoke an issue of a search for some common approaches to treatment of these diseases, along with elaboration of conventional treatment modalities, being specific to individual pathology. (Med. Immunol., vol. 10, N 4-5, pp 307-318).
format	article
author	V. A. Kozlov
author_facet	V. A. Kozlov
author_sort	V. A. Kozlov
title	METHYLATION OF CELLULAR DNA AND PATHOLOGY OF THE ORGANISM
title_short	METHYLATION OF CELLULAR DNA AND PATHOLOGY OF THE ORGANISM
title_full	METHYLATION OF CELLULAR DNA AND PATHOLOGY OF THE ORGANISM
title_fullStr	METHYLATION OF CELLULAR DNA AND PATHOLOGY OF THE ORGANISM
title_full_unstemmed	METHYLATION OF CELLULAR DNA AND PATHOLOGY OF THE ORGANISM
title_sort	methylation of cellular dna and pathology of the organism
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/c12e641d92ea420093898ed79fd939ed
work_keys_str_mv	AT vakozlov methylationofcellulardnaandpathologyoftheorganism
_version_	1718422565843632128

METHYLATION OF CELLULAR DNA AND PATHOLOGY OF THE ORGANISM

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