Role of citicoline and choline in the treatment of post-stroke depression: an exploratory study

Objective To compare selective serotonin reuptake inhibitors (SSRIs) and nootropic drugs in the reduction of anxiety and depressive symptoms in post-stroke patients. Methods This retrospective cohort study included patients diagnosed with post-stroke depression that were treated with either SSRIs or...

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Autores principales:	Francesca Antonia Arcadi, Francesco Corallo, Michele Torrisi, Chiara Scarfì, Viviana Lo Buono, Caterina Formica, Placido Bramanti, Silvia Marino, Lilla Bonanno, Maria Cristina De Cola
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c131048d7fb7483ea93328c3b5430fd6
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spelling	oai:doaj.org-article:c131048d7fb7483ea93328c3b5430fd62021-11-04T00:03:20ZRole of citicoline and choline in the treatment of post-stroke depression: an exploratory study1473-230010.1177/03000605211055036https://doaj.org/article/c131048d7fb7483ea93328c3b5430fd62021-11-01T00:00:00Zhttps://doi.org/10.1177/03000605211055036https://doaj.org/toc/1473-2300Objective To compare selective serotonin reuptake inhibitors (SSRIs) and nootropic drugs in the reduction of anxiety and depressive symptoms in post-stroke patients. Methods This retrospective cohort study included patients diagnosed with post-stroke depression that were treated with either SSRIs or nootropic drugs (i.e. citicoline or choline alphoscerate). Depression and anxiety were assessed using the Hamilton Rating Scales. Statistical associations between the use of nootropic drugs and mood disorder improvements were determined by measuring assessment scores at 6-months. Results A total of 44 post-stroke patients with depression (aged 45–75 years) were enrolled in the study: 20 were treated with SSRIs and 24 received nootropic drugs. From baseline to follow-up, the SSRI group showed a large effect size with regard depression (success rate difference [SRD] 0.57; 95% confidence interval [CI] 0.21, 0.79) and anxiety (SRD 0.49; 95% CI 0.14, 0.74), whereas the nootropic group showed a small effect size for depression (SRD 0.16; 95% CI –0.17, 0.46) and a small effect size for anxiety (SRD 0.36; 95% CI –0.03, 0.62). Conclusion The administration of nootropic drugs could be a valid therapeutic strategy to manage post-stroke patients suffering from mild–moderate anxiety or anxious-depressive syndrome, but this requires further research.Francesca Antonia ArcadiFrancesco CoralloMichele TorrisiChiara ScarfìViviana Lo BuonoCaterina FormicaPlacido BramantiSilvia MarinoLilla BonannoMaria Cristina De ColaSAGE PublishingarticleMedicine (General)R5-920ENJournal of International Medical Research, Vol 49 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Francesca Antonia Arcadi Francesco Corallo Michele Torrisi Chiara Scarfì Viviana Lo Buono Caterina Formica Placido Bramanti Silvia Marino Lilla Bonanno Maria Cristina De Cola Role of citicoline and choline in the treatment of post-stroke depression: an exploratory study
description	Objective To compare selective serotonin reuptake inhibitors (SSRIs) and nootropic drugs in the reduction of anxiety and depressive symptoms in post-stroke patients. Methods This retrospective cohort study included patients diagnosed with post-stroke depression that were treated with either SSRIs or nootropic drugs (i.e. citicoline or choline alphoscerate). Depression and anxiety were assessed using the Hamilton Rating Scales. Statistical associations between the use of nootropic drugs and mood disorder improvements were determined by measuring assessment scores at 6-months. Results A total of 44 post-stroke patients with depression (aged 45–75 years) were enrolled in the study: 20 were treated with SSRIs and 24 received nootropic drugs. From baseline to follow-up, the SSRI group showed a large effect size with regard depression (success rate difference [SRD] 0.57; 95% confidence interval [CI] 0.21, 0.79) and anxiety (SRD 0.49; 95% CI 0.14, 0.74), whereas the nootropic group showed a small effect size for depression (SRD 0.16; 95% CI –0.17, 0.46) and a small effect size for anxiety (SRD 0.36; 95% CI –0.03, 0.62). Conclusion The administration of nootropic drugs could be a valid therapeutic strategy to manage post-stroke patients suffering from mild–moderate anxiety or anxious-depressive syndrome, but this requires further research.
format	article
author	Francesca Antonia Arcadi Francesco Corallo Michele Torrisi Chiara Scarfì Viviana Lo Buono Caterina Formica Placido Bramanti Silvia Marino Lilla Bonanno Maria Cristina De Cola
author_facet	Francesca Antonia Arcadi Francesco Corallo Michele Torrisi Chiara Scarfì Viviana Lo Buono Caterina Formica Placido Bramanti Silvia Marino Lilla Bonanno Maria Cristina De Cola
author_sort	Francesca Antonia Arcadi
title	Role of citicoline and choline in the treatment of post-stroke depression: an exploratory study
title_short	Role of citicoline and choline in the treatment of post-stroke depression: an exploratory study
title_full	Role of citicoline and choline in the treatment of post-stroke depression: an exploratory study
title_fullStr	Role of citicoline and choline in the treatment of post-stroke depression: an exploratory study
title_full_unstemmed	Role of citicoline and choline in the treatment of post-stroke depression: an exploratory study
title_sort	role of citicoline and choline in the treatment of post-stroke depression: an exploratory study
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/c131048d7fb7483ea93328c3b5430fd6
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Role of citicoline and choline in the treatment of post-stroke depression: an exploratory study

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